Considered to be a major portal of entry for infectious agents, the oral cavity is directly associated with the evolutionary process of SARS-CoV-2 in its inhalation of ambient particles in the air and in expectorations. Some new generations of mouth rinses currently on the market have ingredients that could contribute to lower the SARS-CoV-2 viral load, and thus facilitate the fight against oral transmission. If chlorhexidine, a usual component of mouth rinse, is not efficient to kill SARS-CoV-2, the use of a mouth rinses and/or with local nasal applications that contain β-cyclodextrins combined with flavonoids agents, such as Citrox, could provide valuable adjunctive treatment to reduce the viral load of saliva and nasopharyngeal microbiota, including potential SARS-CoV-2 carriage. We urge national agencies and authorities to start clinical trials to evaluate the preventive effects of βCD-Citrox therapeutic oral biofilm rinses in reducing the viral load of the infection and possibly disease progression.
【저자키워드】 COVID-19, SARS-CoV-2, 2019-nCoV, Viral load, Microbiome, mouthrinse, Citrox, oral cavity, β-cyclodextrins, 【초록키워드】 Treatment, Saliva, clinical trial, Infection, Local, Transmission, nasal, Particle, Disease progression, microbiota, nasopharyngeal, therapeutic, ingredient, infectious agents, National, agency, ambient, Effect, evaluate, facilitate, contribute, reducing, reduce, kill, the SARS-CoV-2, 【제목키워드】 Effect, Combined, Preventing,