Background: The Hospital-University Institute (IHU) Méditerranée Infection features a 27,000 square meter building hosting 700 employees and 75 hospitalized patients in the center of Marseille, France. Method: Previous preparedness in contagious disease management allowed the IHU to manage the COVID-19 outbreak by continuing adaptation for optimal diagnosis, care and outcome. We report here the output of this management. Results: From 5 March 2020, and 26 April 2021, 608,313 PCR tests were provided for 424,919 patients and 44,089 returned positive. A total of 23,390 patients with COVID-19 were followed at IHU with an overall case fatality ratio of 1.7%. Of them 20,270 were followed as outpatients with an overall CFR of 0.17%. We performed 24,807 EKG, 5759 low dose CT Scanner, and 18,344 serology. Of the 7643 nasopharyngeal samples inoculated in cell cultures 3317 (43.3%) yielded SARS-Cov-2 isolates. Finally, 7370 SARS-Cov-2 genomes were analyzed, allowing description of the first genetic variants and their implication in the epidemiologic curves. Continuous clinical care quality evaluation provided the opportunity for 155 publications allowing a better understanding of the disease and improvement of care and 132 videos posted on the IHU Facebook network, totaling 60 million views and 390,000 followers, and dealing with COVID-19, outbreaks, epistemology, and ethics in medicine. Conclusions: During this epidemic, IHU Méditerranée Infection played the role for which it has been created; useful clinical research to guarantee a high-quality diagnostic and care for patient and a recognized expertise.
【저자키워드】 Drug repurposing, pandemic, adaptation, preparedness, leadership, autonomy in decision-making, rerouting of tests, unrestricted access to care, 【초록키워드】 serology, Genome, diagnostic, Diagnosis, outcome, Outbreaks, Epidemic, COVID-19 outbreak, management, Cell culture, low dose, Research, Patient, France, Genetic variant, clinical care, PCR test, CFR, disease, case fatality ratio, Care, Outpatient, Marseille, isolates, Facebook, scanner, positive, contagious, nasopharyngeal sample, feature, analyzed, performed, inoculated, the disease, provided, hospitalized patient, returned, Continuous, EKG, patients with COVID-19, with COVID-19, 【제목키워드】 COVID-19, experience,