The link between severe forms of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and cardiovascular diseases has been well documented by various studies that indicated a higher risk of cardiovascular complications in COVID-19 patients, in parallel with a higher risk of mortality in COVID-19 patients with underlying cardiovascular diseases. It seems that inflammation, which is a major pathophysiological substrate for both acute myocardial infarction and severe forms of COVID-19, may play a pivotal role in the interrelation between these two critical conditions, and hypercoagulability associated with SARS-CoV-2 infection could be responsible for acute cardiovascular complications. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) proved to be independent predictors for prognosis in acute coronary syndromes and systemic inflammatory diseases; therefore, they may be used as independent prognostic markers of disease severity in COVID-19 infection. The aim of this review is to present the most recent advances in understanding the complex link between SARS-CoV-2 infection, inflammation and alteration of blood coagulability and hemorheology, leading to major cardiovascular events.
【저자키워드】 SARS-CoV-2, Inflammation, Myocardial infarction, hypercoagulability, NLR, PLR, hemorheology, 【초록키워드】 COVID-19, Mortality, Prognosis, SARS-COV-2 infection, disease severity, Infection, cardiovascular disease, cardiovascular diseases, Neutrophil-to-lymphocyte ratio, COVID-19 infection, Prognostic marker, Critical, COVID-19 patients, Blood, Coronavirus-2, Acute coronary syndrome, Acute myocardial infarction, cardiovascular complications, COVID-19 patient, cardiovascular complication, Cardiovascular events, acute respiratory syndrome, higher risk, complex, independent, systemic inflammatory, responsible, indicated, form, conditions, independent predictor, pathophysiological, 【제목키워드】 cardiovascular, alteration,