This prospective multicenter cohort study aimed to analyze the epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) in children. The study, based on the pediatric part of the Polish SARSTer register, included 1283 children (0 to 18 years) who were diagnosed with COVID-19 between 1 March 2020 and 31 December 2020. Household contact was reported in 56% of cases, more frequently in younger children. Fever was the most common symptom (46%). The youngest children (0–5 years) more frequently presented with fever, rhinitis and diarrhea. Teenagers more often complained of headache, sore throat, anosmia/ageusia and weakness. One fifth of patients were reported to be asymptomatic. Pneumonia was diagnosed in 12% of patients, more frequently in younger children. During the second wave patients were younger than during the first wave (median age 53 vs. 102 months, p < 0.0001) and required longer hospitalization ( p < 0.0001). Significantly fewer asymptomatic patients were noted and pneumonia as well as gastrointestinal symptoms were more common. The epidemiological characteristics of pediatric patients and the clinical presentation of COVID-19 are age-related. Younger children were more frequently infected by close relatives, more often suffered from pneumonia and gastrointestinal symptoms and required hospitalization. Clinical courses differed significantly during the first two waves of the pandemic.
【저자키워드】 Epidemiology, children, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronavirus disease 2019 (COVID-19), clinical presentation, 【초록키워드】 COVID-19, coronavirus disease, pandemic, Hospitalization, Clinical characteristics, Pneumonia, pediatric, Symptom, headache, diarrhea, Clinical course, Characteristics, Asymptomatic, household, Fever, Patient, second wave, epidemiological, First wave, patients, asymptomatic patient, Contact, sore throat, Pediatric patient, median age, weakness, Anosmia/ageusia, Gastrointestinal symptom, multicenter cohort study, significantly, reported, diagnosed, required, suffered, diagnosed with COVID-19, 【제목키워드】 clinical, Wave, second, Part,