Peptide drugs, especially food-derived peptides, have a variety of functional activities including antiviral and may also have a therapeutic effect on COVID-19. In this study, comparing with the reported drugs, 79 peptides were found to bind to the key targets of COVID-19 virus with higher non-covalent interaction, while among them, six peptides showed high non-covalent interactions with the three targets, which may inhibit the COVID-19 virus. In the simulation, peptides of nine to 10 amino acids with a hydrophilic amino acid and acidic amino acid in the middle and aromatic amino acids on the side showed higher binding to angiotensin-converting enzyme 2 (ACE2). Peptides of five to six amino acids with a basic amnio acid in the head, acidic amnio acid in the neck, hydrophobicity group in the middle, and basic amino acids in the tail showed higher binding to COVID-19 virus main protease (M pro ), while those with basic amino acids and acidic amino acids in the two sides and aromatic amino acids in the middle might have stronger interaction with COVID-19 virus RNA-dependent RNA polymerase (RdRp).
【저자키워드】 molecular docking, molecular dynamic simulation, food peptides, COVID-19 virus, 【초록키워드】 COVID-19, ACE2, Antiviral, peptide, drugs, protease, virus, angiotensin-converting enzyme 2, activity, Simulation, peptides, amino acids, COVID-19 virus, RdRP, RNA-dependent RNA polymerase, hydrophobicity, target, targets, RNA polymerase, binding, Angiotensin-converting enzyme, Amino acid, Interaction, angiotensin, (RdRp), head, M pro, Acidic, therapeutic effect, side, middle, tail, FIVE, reported, inhibit, nine, functional, variety, hydrophilic, aromatic amino acid, with COVID-19, 【제목키워드】 COVID-19, Screening, modeling, target, food,