Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) belongs to the group of Betacoronaviruses. The SARS-CoV-2 is closely related to SARS-CoV-1 and probably originated either from bats or pangolins. SARS-CoV-2 is an etiological agent of COVID-19, causing mild to severe respiratory disease which escalates to acute respiratory distress syndrome (ARDS) or multi-organ failure. The virus was first reported from the animal market in Hunan, Hubei province of China in the month of December, 2019, and was rapidly transmitted from animal to human and human-to-human. The human-to-human transmission can occur directly or via droplets generated during coughing and sneezing. Globally, around 53.9 million cases of COVID-19 have been registered with 1.31 million confirmed deaths. The people > 60 years, persons suffering from comorbid conditions and immunocompromised individuals are more susceptible to COVID-19 infection. The virus primarily targets the upper and the lower respiratory tract and quickly disseminates to other organs. SARS-CoV-2 dysregulates immune signaling pathways which generate cytokine storm and leads to the acute respiratory distress syndrome and other multisystemic disorders.
【저자키워드】 COVID-19, SARS-CoV-2, Coronaviruses, spike glycoprotein, acute respiratory distress syndrome (ARDS), ACE2 receptors, 【초록키워드】 Respiratory distress syndrome, ARDS, Cytokine storm, acute respiratory distress syndrome, cytokine, droplet, severe acute respiratory syndrome coronavirus-2, droplets, severe acute respiratory syndrome Coronavirus, virus, SARS-CoV-1, China, Severe acute respiratory syndrome, COVID-19 infection, animal, Respiratory disease, Mild, bat, target, respiratory, bats, betacoronaviruses, acute respiratory distress, Coronavirus-2, Pathways, deaths, Lower respiratory tract, leads, respiratory distress, acute respiratory syndrome, acute respiratory syndrome coronavirus, disorders, immunocompromised individuals, individual, severe respiratory disease, syndrome, other organs, Registered, multi-organ failure, multisystemic, human-to-human transmission, etiological agent, comorbid conditions, pangolins, coughing, sneezing, immune signaling pathways, susceptible, reported, transmitted, generate, occur, comorbid condition, disseminate, immune signaling pathway, 【제목키워드】 Genome, SARS Coronavirus,