In much of the developing world, severe malnutrition is the most prevalent cause of immunodeficiency and affects up to 50% of the population in some impoverished communities. As yet, we do not know how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will behave in populations with immunodeficiency caused by malnourishment. ABSTRACT In much of the developing world, severe malnutrition is the most prevalent cause of immunodeficiency and affects up to 50% of the population in some impoverished communities. As yet, we do not know how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will behave in populations with immunodeficiency caused by malnourishment. Interestingly, researchers are now speculating that, in some instances, a defective cellular immune system could paradoxically be a protective factor against severe disease in certain patients contracting SARS-CoV and SARS-CoV-2. This could be linked to the absence of T-cell activation. Based on available information presented here, it is plausible that the hyperimmune response, and subsequent cytokine storm often associated with severe coronavirus disease 2019 (COVID-19), could be “counteracted” by the defective immune response seen in individuals with malnutrition-induced leptin deficiency. In this paper, we proposed a theory that although those with malnutrition-linked leptin deficiency are at risk of SARS-CoV-2 infection, they are at lower risk of developing severe COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, Cytokine storm, Malnutrition, undernutrition, leptin deficiency, 【초록키워드】 coronavirus, immune response, severe COVID-19, SARS-CoV, SARS-COV-2 infection, immunodeficiency, risk, immune system, Population, Patient, information, cellular, severe disease, deficiency, acute respiratory syndrome, severe malnutrition, severe coronavirus disease, individual, lower risk, protective factor, T-cell activation, instances, researcher, Affect, prevalent, caused, subsequent, absence, hyperimmune response, malnourishment, 【제목키워드】 protection, Leptin,