Recent investigations have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is able to resist on the surfaces and that the diffusion occurs through droplets that can remain suspended in the air as an aerosol. The ozone generated in situ from oxygen is an active ingredient with a ‘biocidal’ action, but little is known about its capacity to inactivate specifically SARS-CoV-2. Here we show, for the first time, the efficiency of the ozone treatment to neutralize the SARS-CoV-2 present in nasopharynx secretion samples with high viral load. Our data show that ozone is effective in SARS-CoV-2 elimination. Highlights • SARS-CoV-2 diffusion occurs through droplets that can remain suspended in the air as an aerosol and can deposit on surfaces. • Here we show that ozone can inactivate the SARS-CoV-2 present in mucosal samples. • Ozone treatment neutralizes SARS-CoV-2 open reading frame 1ab (ORF1ab) and the protein E and the nucleocapsid protein (N) genes. • Ozone is effective for SARS-CoV-2 disinfection of work environments and living rooms.
【저자키워드】 COVID-19, SARS-CoV-2, Disinfection, Ozone, 【초록키워드】 Treatment, coronavirus, oxygen, droplet, nucleocapsid protein, Protein, Viral load, nasopharynx, ingredient, mucosal, ORF1ab, Efficiency, acute respiratory syndrome, Frame, secretion, diffusion, Genes, recent, neutralize, shown, occur, the SARS-CoV-2, 【제목키워드】 Novel coronavirus, mucosal,