Introduction We evaluated several biological indicators based on inflammation and/or nutritional status, such as systemic immune-inflammation index (SII), early warning score (ANDC) and prognostic nutritional index (PNI) in hospitalized COVID-19 patients with and without malignancies for a prognostic significance. Methodology This is a retrospective and observational study on 186 patients with SARS-CoV-2, who were diagnosed with COVID-19 by real-time PCR testing and hospitalized due to COVID-19 pneumonia. 75 patients had various malignancies, and the rest (111), having a similar age and comorbidity profile based on propensity score matching, had no malignancy. Results None of the measures as neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, monocyte to lymphocyte ratio, SII, PNI or ANDC was found to be significantly different between two groups. Odds ratio for the mortality, OR 2.39 (%95 CI 1.80–3.16) was found to be significantly higher for the malignancy group, even though the duration of hospitalization was statistically similar for both groups. PNI was found to be significantly lower for deceased patients compared with survivors in the malignancy group. Contrarily, ANDC was found to be significantly higher for deceased patients in the malignancy group. Conclusions PNI and ANDC have independent predictive power on determining the in-hospital death in COVID-19 malignancy cases. It is suggested that ANDC seems to be a more sensitive score than SII in COVID-19 cases with malignancies.
【저자키워드】 COVID-19 pneumonia, malignancy, PNI, SII, ANDC, 【초록키워드】 COVID-19, Inflammation, Hospitalized, Mortality, Pneumonia, neutrophil, Comorbidity, monocyte, lymphocyte, Real-time PCR, Patient, Platelet, age, prognostic, hospitalized COVID-19 patient, Early warning score, retrospective, propensity score matching, Deceased, nutritional status, In-hospital death, two groups, both groups, COVID-19 case, measure, malignancies, predictive power, significantly lower, survivor, duration of hospitalization, independent, Result, significantly, evaluated, suggested, significantly higher, had no, statistically, diagnosed with COVID-19, patients with SARS-CoV-2, 【제목키워드】 COVID-19, Mortality, prognostic, Early warning score, hospitalized patient,