Cardiomyocyte injury and troponin T elevation has been reported within COVID-19 patients and are associated with a worse prognosis. Limited data report this association among COVID-19 pregnant patients. Objective: We aimed to analyze the association between troponin T levels in severe COVID-19 pregnant women and risk of viral sepsis, intensive care unit (ICU) admission, or maternal death. Methods: We performed a prospective cohort of all obstetrics emergency admissions from a Mexican National Institute. All pregnant women diagnosed by reverse transcription-polymerase chain reaction (RT-qPCR) for SARS-CoV-2 infection between October 2020 and May 2021 were included. Clinical data were collected, and routine blood samples were obtained at hospital admission. Seric troponin T was measured at admission. Results: From 87 included patients, 31 (35.63%) had severe COVID-19 pneumonia, and 6 (6.89%) maternal deaths. ROC showed a significant relationship between troponin T and maternal death (AUC 0.979, CI 0.500–1.000). At a cutoff point of 7 ng/mL the detection rate for severe pneumonia was 83.3% (95%CI: 0.500–0.100) at 10% false-positive rate. Conclusion: COVID-19 pregnant women with elevated levels of troponin T present a higher risk of death and severe pneumonia.
【저자키워드】 COVID-19, Maternal death, troponin T, 【초록키워드】 Severe COVID-19 pneumonia, COVID-19 pneumonia, intensive care, severe COVID-19, Pneumonia, SARS-COV-2 infection, intensive care unit, risk, Sepsis, ICU, pregnant women, obstetrics, polymerase chain reaction, RT-qPCR, Viral, ROC, clinical, Maternal death, death, troponin T, Hospital admission, severe pneumonia, prospective cohort, Admission, detection rate, patients, COVID-19 patients, False-positive, association, Reverse transcription-polymerase chain reaction, Injury, deaths, COVID-19 patient, AUC, Chain Reaction, maternal deaths, higher risk, Clinical data, blood sample, worse prognosis, pregnant patients, cutoff point, was measured, performed, collected, reported, diagnosed, elevated, Limited, 【제목키워드】 Maternal, Maternal death, troponin T, Level,