SARS-CoV-2 RT-PCR, the gold standard for diagnostic testing, may not be readily available or logistically applicable for routine COVID-19 testing in many rural communities in the United States. In this validation study, we compared the BinaxNOW™ COVID-19 Test Ag Card with SARS-CoV-2 RT-PCR in 214 participants who sought COVID-19 testing from a local public health district in Idaho, USA. The median age of participants was 35 and 82.7% were symptomatic. Thirty-seven participants (17.3%) had positive RT-PCR results. Results between the two tests were 94.4% concordant. The sensitivity of the BinaxNOW™ COVID-19 Test Ag Card was 67.6% (95% CI: 50.2–81.9%), and the specificity was 100.0% (95% CI: 97.9–100.0%). The positive predictive value (PPV) for the BinaxNOW™ COVID-19 Test Ag Card was 100.0% (95% CI: 86.2–100.0%), and the negative predictive value (NPV) was 93.6% (95% CI: 89.1–96.6%). Although the sensitivity of BinaxNOW™ COVID-19 Test Ag Card was lower than RT-PCR, rapid results and high specificity support its use for early detection of COVID-19, especially in settings where SARS-CoV-2 RT-PCR testing is not readily available. Rapid antigen tests, such as the BinaxNOW™ COVID-19 Test Ag Card, may be a more convenient tool in quickly identifying and preventing COVID-19 transmission, especially in rural settings.
【초록키워드】 COVID-19, Test, diagnostic, RT-PCR, Predictive value, Antigen, sensitivity, specificity, Rapid antigen tests, COVID-19 testing, Positive predictive value, symptomatic, Early detection, diagnostic testing, Rapid, Community, gold, United States, SARS-CoV-2 RT-PCR, USA, positive RT-PCR, local public health, Negative predictive value, COVID-19 transmission, Support, 95% CI, RT-PCR testing, gold standard, median age, participant, validation study, Card, The United States, Result, NPV, PPV, 【제목키워드】 COVID-19, SARS-COV-2 infection, Test, local public health, Abbott,