Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may be underestimated because of limited access to testing. We measured SARS-CoV-2 seroprevalence in South Africa every 2 months during July 2020–March 2021 in randomly selected household cohorts in 2 communities. We compared seroprevalence to reported laboratory-confirmed infections, hospitalizations, and deaths to calculate infection–case, infection–hospitalization, and infection–fatality ratios in 2 waves of infection. Post–second wave seroprevalence ranged from 18% in the rural community children <5 years of age, to 59% in urban community adults 35–59 years of age. The second wave saw a shift in age distribution of case-patients in the urban community (from persons 35–59 years of age to persons at the extremes of age), higher attack rates in the rural community, and a higher infection–fatality ratio in the urban community. Approximately 95% of SARS-CoV-2 infections were not reported to national surveillance.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, SARS-CoV-2, Coronaviruses, Seroprevalence, South Africa, infection–case ratio, infection–hospitalization ratio, infection–fatality ratio, 【초록키워드】 coronavirus, SARS-COV-2 infection, children, Infection, Cohort, infections, SARS-CoV-2 seroprevalence, Surveillance, attack rate, hospitalizations, death, Community, second wave, age, distribution, acute respiratory syndrome, infection–fatality ratio, National, laboratory-confirmed, Randomly, extreme, selected, reported, ranged, calculate, 【제목키워드】 household, urban, Wave, second,