We report 2 fatal exacerbations of systemic capillary leak syndrome (SCLS), also known as Clarkson disease, associated with coronavirus disease (COVID-19) in the United States. One patient carried an established diagnosis of SCLS and the other sought treatment for new-onset hypotensive shock, hemoconcentration, and anasarca, classic symptoms indicative of an SCLS flare. Both patients had only mild-to-moderate symptoms of COVID-19. This clinical picture suggests that these patients succumbed to complications of SCLS induced by infection with severe acute respiratory syndrome coronavirus 2. Persons with known or suspected SCLS may be at increased risk for developing a disease flare in the setting of mild-to-moderate COVID-19 infection.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, SARS-CoV-2, multiple organ failure, Clarkson disease, systemic capillary leak syndrome, capillary leaks, 【초록키워드】 Treatment, coronavirus, Infection, Diagnosis, Symptom, Shock, COVID-19 infection, clinical picture, Patient, Complication, disease, Mild-to-moderate, acute respiratory syndrome, increased risk, one patient, symptoms of COVID-19, The United States, carried, capillary leak syndrome, Person, 【제목키워드】 capillary, systemic, Exacerbation, leak,