A causal relationship between plasma ceramide concentration and respiratory distress symptoms in COVID-19 patients is inferred. In this study, plasma samples of 52 individuals infected with COVID-19 were utilized in a lipidomic analysis. Lipids belonging to the ceramide class exhibited a 400-fold increase in total plasma concentration in infected patients. Further analysis led to the demonstration of concentration dependency for severe COVID-19 respiratory symptoms in a subclass of ceramides. The subclasses Cer(d18:0/24:1), Cer(d18:1/24:1), and Cer(d18:1/22:0) were shown to be increased by 48-, 40-, and 33-fold, respectively, in infected plasma samples and to 116-, 91- and 50-fold, respectively, in plasma samples with respiratory distress. Hence, monitoring plasma ceramide concentration, can be a valuable tool for measuring effects of therapies on COVID-19 respiratory distress patients.
【저자키워드】 Translational research, viral infection, Biomarkers, Drug development, 【초록키워드】 COVID-19, therapy, severe COVID-19, Symptom, Ceramides, plasma, respiratory, lipids, patients, Concentration, Lipid, Analysis, distress, COVID-19 patient, respiratory symptoms, respiratory distress, causal relationship, ceramide, plasma concentration, infected patients, individual, plasma samples, respiratory symptom, demonstration, subclass, Effect, plasma sample, shown, exhibited, increase in, infected with COVID-19, 【제목키워드】 COVID-19, distress,