Background To investigate the association between serum 25-hydroxyvitamin D levels and its effect on adverse clinical outcomes, and parameters of immune function and mortality due to a SARS-CoV-2 infection. Study design The hospital data of 235 patients infected with COVID-19 were analyzed. Results Based on CDC criteria, among our study patients, 74% had severe COVID-19 infection and 32.8% were vitamin D sufficient. After adjusting for confounding factors, there was a significant association between vitamin D sufficiency and reduction in clinical severity, inpatient mortality serum levels of C-reactive protein (CRP) and an increase in lymphocyte percentage. Only 9.7% of patients older than 40 years who were vitamin D sufficient succumbed to the infection compared to 20% who had a circulating level of 25(OH)D< 30 ng/ml. The significant reduction in serum CRP, an inflammatory marker, along with increased lymphocytes percentage suggest that vitamin D sufficiency also may help modulate the immune response possibly by reducing risk for cytokine storm in response to this viral infection. Conclusion Therefore, it is recommended that improving vitamin D status in the general population and in particular hospitalized patients has a potential benefit in reducing the severity of morbidities and mortality associated with acquiring COVID-19.
【초록키워드】 COVID-19, viral infection, Cytokine storm, immune response, Lymphocytes, Mortality, Vitamin D, SARS-COV-2 infection, 25-hydroxyvitamin D, severity, hospital, Infection, C-reactive protein, risk, cytokine, clinical outcomes, lymphocyte, serum, Viral, COVID-19 infection, morbidity, Patient, Study design, immune function, General population, patients, association, marker, Clinical severity, Vitamin D status, Inflammatory, C-reactive protein (CRP, Severe COVID-19 Infection, Serum level, morbidities, help, serum 25-hydroxyvitamin D, circulating, CDC criteria, confounding factors, serum CRP, vitamin D sufficiency, parameter, benefit, Result, analyzed, hospitalized patient, reducing, modulate, increase in, reduction in, infected with COVID-19, patients older, 【제목키워드】 Vitamin D, Infection, Clinical outcome, reduced risk, serum 25-hydroxyvitamin D, patients with COVID-19,