A group of 110 patients from the West Bohemian region who had been infected with COVID-19 was monitored for the purposes of this study. We focused on cases of mild or moderate COVID-19; statistically the most likely to occur. Day zero was defined as the day on which a positive PCR test was first established. The mean length of observation was 6.5 months, the maximum length 12 months. The first blood samples were taken from a smaller cohort during the 1–3 months following the first positive PCR test. We assumed that SARS-CoV-2 antibodies would be present during this period and therefore a limited number of samples were taken for the purpose of detecting antibodies. More samples were collected, starting 4 months after the first positive PCR test. A subsequent set of blood samples were drawn, mostly 6 months after the first ones. Our study confirmed the presence of total IgG SARS-CoV-2 antibodies up to 1 year after the onset of the disease. The peak of antibody production was observed in the third month after the first positive PCR test. A mathematical estimate of the median duration of antibody positivity was calculated to be 18 months from the onset of the COVID-19 infection.
【저자키워드】 COVID-19, SARS-CoV-2, antibody, nucleocapsid protein, immunoassay, serological diagnostics, time period, 【초록키워드】 antibodies, Cohort, SARS-CoV-2 antibody, COVID-19 infection, Patient, Mild, PCR test, moderate, antibody production, observation, blood sample, positive PCR test, West, first positive, defined, collected, subsequent, the disease, Day, calculated, occur, mathematical, statistically, assumed, IgG SARS-CoV-2 antibody, infected with COVID-19, number of sample, the median, 【제목키워드】 response, monitoring,