Aim: To investigate the prospective anti COVID-19 activity of Egyptian propolis. Material & methods: Propolis samples were collected from different Egyptian geographical areas and characterized using standardized methods, scanning electron microscope and gas chromatography/mass spectrometry along with computational modeling to predict the anti-COVID-19 activity. Results & conclusion: Gas chromatography/mass spectrometry analysis of Menoufia propolis proved the presence of Octatriacontyl pentafluoropropionate (4.2%). Docking analyses declared that Octatriacontyl pentafluoropropionate is well oriented inside the enzyme pockets, in addition to excellent binding manner with the active site of the target macromolecules (RNA-dependent RNA polymerase, Spike protein S1 and main protease) in relation to some broad-spectrum antiviral agents. Menoufia propolis could be a promising candidate in the combat against the pandemic COVID-19.
【저자키워드】 Propolis, Lopinavir, Remdesivir, umifenovir, Anti-COVID-19, computational modeling, 【초록키워드】 COVID-19, pandemic, protease, Antiviral agents, RNA-dependent RNA polymerase, predict, binding, Analysis, geographical area, enzyme, material, spike protein S1, macromolecule, Result, collected, addition, characterized, 【제목키워드】 Potential,