Abstract Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease (COVID-19). However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, Chloroquine, Hydroxychloroquine, 【초록키워드】 Treatment, coronavirus disease, coronavirus, clinical trial, Chloroquine, Hydroxychloroquine, repurposing, drug, Prophylactic, severe acute respiratory syndrome Coronavirus, therapeutic, HCQ, respiratory, Antimalarial drugs, SARS-CoV-2 infections, mechanism, cellular, Invasion, proliferation, antimalarial drug, not effective, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, cultured cells, preliminary findings, effective, benefit, inhibit, the disease, question, 【제목키워드】 Cell,
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, Chloroquine, Hydroxychloroquine, 【초록키워드】 Treatment, coronavirus disease, coronavirus, clinical trial, Chloroquine, Hydroxychloroquine, repurposing, drug, Prophylactic, severe acute respiratory syndrome Coronavirus, therapeutic, HCQ, respiratory, Antimalarial drugs, SARS-CoV-2 infections, mechanism, cellular, Invasion, proliferation, antimalarial drug, not effective, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, cultured cells, preliminary findings, effective, benefit, inhibit, the disease, question, 【제목키워드】 Cell,
초록 클로로퀸(CQ)과 하이드록시클로로퀸(HCQ)은 배양된 세포에서 중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2)의 침입과 증식을 억제할 수 있기 때문에 이러한 항말라리아 약물의 용도 변경은 치료 및 예방을 위한 유망한 전략으로 간주되었습니다. 코로나바이러스 질병(COVID-19)의. 그러나 유망한 예비 발견에도 불구하고 많은 임상 시험에서 COVID-19에 대한 CQ 및 HCQ의 유의한 치료적 또는 예방적 이점을 보여주지 못했습니다. 여기에서 우리는 SARS-CoV-2 감염 예방에서 CQ와 HCQ의 세포 작동 메커니즘을 조사하여 이러한 약물이 질병에 효과적이지 않은 이유에 대한 질문에 답하는 것을 목표로 합니다.