(1) Background: Vitamin D, a well-established regulator of calcium and phosphate metabolism, also has immune-modulatory functions. An uncontrolled immune response and cytokine storm are tightly linked to fatal courses of COVID-19. The present retrospective study aimed to inves-tigate vitamin D status markers and vitamin D degradation products in a mixed cohort of 148 hospitalized COVID-19 patients with various clinical courses of COVID-19. (2) Methods: The serum concentrations of 25(OH)D 3 , 25(OH)D 2 , 24,25(OH) 2 D 3 , and 25,26(OH) 2 D 3 were determined by a validated liquid-chromatography tandem mass-spectrometry method in leftover serum samples from 148 COVID-19 patients that were admitted to the University Hospital of the Medical Uni-versity of Graz between April and November 2020. Anthropometric and clinical data, as well as outcomes were obtained from the laboratory and hospital information systems. (3) Results: From the 148 patients, 34 (23%) died within 30 days after admission. The frequency of fatal outcomes did not differ between males and females. Non-survivors were significantly older than survivors, had higher peak concentrations of IL-6 and CRP, and required mechanical ventilation more frequently. The serum concentrations of all vitamin D metabolites and the vitamin D metabolite ratio (VMR) did not differ significantly between survivors and non-survivors. Additionally, the need for res-piratory support was unrelated to the serum concentrations of 25(OH)D vitamin D and the two vitamin D catabolites, as well as the VMR. (4) Conclusion: The present results do not support a relevant role of vitamin D for the course and outcome of COVID-19.
【저자키워드】 COVID19, Clinical outcome, vitamin D metabolites, 【초록키워드】 COVID-19, Cytokine storm, immune response, Vitamin D, mechanical ventilation, IL-6, hospital, CRP, cytokine, outcome, metabolism, Laboratory, Retrospective study, serum, Cohort, Clinical course, Survivors, male, Degradation, information, university, Admission, patients, calcium, metabolite, hospitalized COVID-19 patient, marker, Vitamin D status, Frequency, Concentration, COVID-19 patient, degradation products, determined by, phosphate, peak concentrations, clinical courses, hospital information systems, Information Systems, Support, Non-survivors, Older, Clinical data, university hospital, serum concentrations, functions, serum sample, survivor, Graz, females, peak concentration, Course, not differ, died, significantly, required, 【제목키워드】 COVID-19, Vitamin D, clinical,