We aimed to study the possible association of stress hyperglycemia in COVID-19 critically ill patients with prognosis, artificial nutrition, circulating osteocalcin, and other serum markers of inflammation and compare them with non-COVID-19 patients. Fifty-two critical patients at the intensive care unit (ICU), 26 with COVID-19 and 26 non-COVID-19, were included. Glycemic control, delivery of artificial nutrition, serum osteocalcin, total and ICU stays, and mortality were recorded. Patients with COVID-19 had higher ICU stays, were on artificial nutrition for longer ( p = 0.004), and needed more frequently insulin infusion therapy ( p = 0.022) to control stress hyperglycemia. The need for insulin infusion therapy was associated with higher energy ( p = 0.001) and glucose delivered through artificial nutrition ( p = 0.040). Those patients with stress hyperglycemia showed higher ICU stays (23 ± 17 vs. 11 ± 13 days, p = 0.007). Serum osteocalcin was a good marker for hyperglycemia, as it inversely correlated with glycemia at admission in the ICU ( r = −0.476, p = 0.001) and at days 2 ( r = −0.409, p = 0.007) and 3 ( r = −0.351, p = 0.049). In conclusion, hyperglycemia in critically ill COVID-19 patients was associated with longer ICU stays. Low circulating osteocalcin was a good marker for stress hyperglycemia.
【저자키워드】 COVID-19, hyperglycemia, parenteral nutrition, enteral nutrition, osteocalcin, 【초록키워드】 Inflammation, therapy, Mortality, intensive care, Stress, Prognosis, intensive care unit, ICU, serum, Critically ill, Patient, hyperglycemia, osteocalcin, insulin, Admission, Critical, glycemic control, critically ill patients, Glucose, association, marker, COVID-19 patient, critically ill COVID-19 patients, serum markers, Infusion Therapy, Critically ill patient, Non-COVID-19, Non-COVID-19 patients, circulating, glycemia, correlated, were recorded, with COVID-19, 【제목키워드】 nutrition, artificial, Ill,