Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused millions of infections and deaths worldwide since its emergence in December 2019. As there is little or no natural immunity in the human population or specific anti-COVID-19 drugs, researchers from the government, academia and industry are developing vaccines at an unprecedented speed to halt the pandemic. In this review, the results of animal experiments and clinical trials on several vaccine technical platforms are summarized, and several challenges are also discussed to further promote the development, evaluation and application of vaccines during the challenging situation of the global pandemic.
【저자키워드】 COVID-19, SARS-CoV-2, Vaccine, clinical trials, breath, vaccine candidate, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, coronavirus, clinical trial, pandemic, Infection, drugs, clinical trials, severe acute respiratory syndrome Coronavirus, global pandemic, animal experiments, death, experiment, respiratory, platform, natural immunity, human population, Government, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, researcher, caused, promote, 【제목키워드】 pandemic era,