OBJECTIVES: To compare demographic/clinical/laboratory/treatments and outcomes among children and adolescents with laboratory-confirmed coronavirus disease 2019 (COVID-19). METHODS: This was a cross-sectional study that included patients diagnosed with pediatric COVID-19 (aged <18 years) between April 11, 2020 and April 22, 2021. During this period, 102/5,951 (1.7%) of all admissions occurred in neonates, children, and adolescents. Furthermore, 3,962 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection samples were processed in patients aged <18 years, and laboratory-confirmed COVID-19 occurred in 155 (4%) inpatients and outpatients. Six/155 pediatric patients were excluded from the study. Therefore, the final group included 149 children and adolescents (n=97 inpatients and 52 outpatients) with positive SARS-CoV-2 results. RESULTS: The frequencies of sore throat, anosmia, dysgeusia, headache, myalgia, nausea, lymphopenia, pre-existing chronic conditions, immunosuppressive conditions, and autoimmune diseases were significantly reduced in children and adolescents ( p <0.05). Likewise, the frequencies of enoxaparin use ( p =0.037), current immunosuppressant use ( p =0.008), vasoactive agents ( p =0.045), arterial hypotension ( p <0.001), and shock ( p =0.024) were significantly lower in children than in adolescents. Logistic regression analysis showed that adolescents with laboratory-confirmed COVID-19 had increased odds ratios (ORs) for sore throat (OR 13.054; 95% confidence interval [CI] 2.750-61.977; p =0.001), nausea (OR 8.875; 95% CI 1.660-47.446; p =0.011), and lymphopenia (OR 3.575; 95% CI 1.355-9.430; p =0.010), but also had less hospitalizations (OR 0.355; 95% CI 0.138-0.916; p =0.032). The additional logistic regression analysis on patients with preexisting chronic conditions (n=108) showed that death as an outcome was significantly associated with pediatric severe acute respiratory syndrome (SARS) (OR 22.300; 95% CI 2.341-212.421; p =0.007) and multisystem inflammatory syndrome in children (MIS-C) (OR 11.261; 95% CI 1.189-106. 581; p =0.035). CONCLUSIONS: Half of the laboratory-confirmed COVID-19 cases occurred in adolescents. Individuals belonging to this age group had an acute systemic involvement of SARS-CoV-2 infection. Pediatric SARS and MIS-C were the most important factors associated with the mortality rate in pediatric chronic conditions with COVID-19.
【저자키워드】 COVID-19, children, outcome, chronic disease, Multisystem inflammatory syndrome, Adolescent, 【초록키워드】 coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, coronavirus, Hospitalization, cross-sectional, SARS-COV-2 infection, pediatric, severe acute respiratory syndrome Coronavirus, headache, MIS-C, Anosmia, lymphopenia, Autoimmune disease, Shock, dysgeusia, Neonates, cross-sectional study, Pediatric patients, Patient, enoxaparin, death, age, outpatients, mortality rate, respiratory, Autoimmune diseases, chronic condition, Admission, Frequency, Inflammatory, Odds ratio, chronic conditions, myalgia, Inpatients, regression analysis, sore throat, Inpatient, acute respiratory syndrome, Factor, Pediatric patient, Logistic regression analysis, frequencies, 95% CI, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, 95% confidence interval, Laboratory-confirmed COVID-19, COVID-19 case, individual, Odds ratios, syndrome, nausea, Final, positive, laboratory-confirmed, significantly lower, immunosuppressive conditions, occurred, significantly, diagnosed, reduced, less, processed, vasoactive agent, were excluded, with COVID-19, 【제목키워드】 SARS-CoV-2, cohort study, difference, tertiary referral hospital,