A dynamic simulation study of FDA drug from zinc database against COVID-19 main protease receptorCOVID-19 주요 프로테아제 수용체에 대한 아연 데이터베이스에서 FDA 약물의 동적 시뮬레이션 연구Article Published on 2022-02-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] accelerate approved binding calculated clinical study Compound compounds contagious COVID-19 database death drug drug candidate enzyme FDA FDA drugs FDA-approved drug FDA-approved drugs global public health globe Glu166 identify in silico Approach in vitro in vivo Initially lead library main protease MD simulation molecular molecular docking molecular dynamic simulation molecular dynamics MPro outbreak PCA protease provide receptor Research residue responsible RMSD RMSF SARS-CoV-2 selected Seven Spread trajectory was used Zinc ZINC database zinc database. [DOI] 10.1080/07391102.2020.1821785 PMC 바로가기 [Article Type] Article
A Multi-Disulfide Receptor-Binding Domain (RBD) of the SARS-CoV-2 Spike Protein Expressed in E. coli Using a SEP-Tag Produces Antisera Interacting with the Mammalian Cell Expressed Spike (S1) ProteinArticle Published on 2022-02-012022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Escherichia coli expression accelerate ACE2 addition Analysis Antisera arginine residue binding activity C-terminus demonstrated denaturation disulfide bond E. coli elicited ELISA Epitopes Escherichia coli expressed expression Final FIVE fusion tag Host IgG immune response immunogenicity Inclusion mice nine overcome peptide Produce RBD receptor resulting scattering significantly solubility soluble fraction spike Spike protein the receptor-binding domain the SARS-CoV-2 Wuhan-Hu-1 [DOI] 10.3390/ijms23031703 PMC 바로가기 [Article Type] Article
NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severityMini review Published on 2022-02-012022-10-05 Journal: Microbes and infection [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 유전자 메커니즘, [키워드] accelerate activated Activation Affect Comorbidities Comorbidity condition correlated COVID-19 COVID-19 disease severity creating Critical death deleterious effect disease disease severity downstream dysregulated dysregulation event immune immune component immune response Immunity individual Infection inflammasome activation Inflammatory innate immune responses Interaction knowledge NLRP3 NLRP3 inflammasome Occurrence pathophysiology required risk factor Risk factors severe COVID-19 severity of COVID-19 Therapeutic approach Therapeutics Treatment underlying disorders [DOI] 10.1016/j.micinf.2021.104913 [Article Type] Mini review
A knowledge graph to interpret clinical proteomics data Research Published on 2022-01-312022-10-05 Journal: Nature biotechnology [Category] 바이오마커, 신약개발, 진단, [키워드] accelerate Analysis Biomarker clinical clinically database flexible help Implementing Interpretation knowledge Knowledge graph machine learning algorithm platform Precision proteomics proteomics data provide Spread statistical [DOI] 10.1038/s41587-021-01145-6 [Article Type] Research
A Peek into Pandora’s Box: COVID-19 and NeurodegenerationReview Published on 2022-01-302022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] accelerate ACE2 Activation acute respiratory syndrome angiotensin-converting enzyme 2 association Biomarker Brain Central nervous system changes CNS Comorbidity coronavirus COVID-19 current disease disease severity distress Effects gastrointestinal system hypoxia indirect effect individual induce mechanism Mitochondria molecular biology technique neurodegeneration neurodegenerative Neuron organ systems oxidative stress Proinflammatory cytokine provide pulmonary complications receptor renal reported SARS-CoV-2 SARS-COV-2 infection surviving patients susceptibility susceptible therapeutic Therapeutics Vaccine development Variability variant virus virus attack Wuhan, China [DOI] 10.3390/brainsci12020190 PMC 바로가기 [Article Type] Review
The impact of the COVID-19 pandemic and associated suppression measures on the burden of tuberculosis in IndiaResearch Published on 2022-01-272022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, SARS, [키워드] absence accelerate association available data average changed characterized correlated COVID-19 COVID-19 pandemic death determine Diagnosis diagnostic division expected Factor greater help highest Hospital admission identify impacted IMPROVE India information Intervention Linear regression lockdown logit measure Mobility pandemic performed Poisson model reported Research Result state supplementary material territory Tuberculosis [DOI] 10.1186/s12879-022-07078-y PMC 바로가기 [Article Type] Research
Extended interval BNT162b2 vaccination enhances peak antibody generationArticle Published on 2022-01-272022-10-04 Journal: NPJ Vaccines [Category] 진단, [키워드] accelerate Adaptive immune response antibody Antibody Response BNT162b2 BNT162b2 vaccine boost booster vaccination country Coverage COVID-19 infection effective ENhance Extended extended-interval immune response magnitude mRNA vaccination offer Older response RNA vaccines second dose single vaccine the timing Translational research vaccination Vaccine [DOI] 10.1038/s41541-022-00432-w PMC 바로가기 [Article Type] Article
Pooling saliva samples as an excellent option to increase the surveillance for SARS-CoV-2 when re-opening community settings커뮤니티 설정을 다시 열 때 SARS-COV-2에 대한 감시를 늘리는 훌륭한 옵션으로 타액 샘플을 풀링Research Article Published on 2022-01-252022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, [키워드] accelerate activities activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition can be used carried caused Community coronavirus country develop Diagnosis diagnostic procedures feasibility FIVE Infection Laboratory testing occurred overcome pooling reagents reported respiratory reverse transcription RNA RT-qPCR Saliva SARS-CoV-2 SARS-CoV-2 genome Schools second wave severe acute respiratory syndrome Coronavirus shortage of reagent shortage of reagents significantly speed Surveillance tested triggering universities Viral Viral RNA [DOI] 10.1371/journal.pone.0263114 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Serological and Biomolecular Analyses among Companion Animals in Campania Region (2020–2021)Communication Published on 2022-01-242022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] accelerate ACE2 affected animal animal hosts anti-N antibody Campania cat cellular receptor collected COVID-19 described dog Evolution FIVE high mutation rate moderate neutralizing antibody titers no difference Prevalence real-time RT-PCR Region reservoir risk RT-PCR SARS-CoV-2 SARS-COV-2 infection serological serology seropositive significantly Surveillance susceptible tested Transmission transmission of SARS-CoV-2 variants Viral RNA viral strains wild animals with COVID-19 [DOI] 10.3390/microorganisms10020263 PMC 바로가기 [Article Type] Communication
The Evolution and Disparities of Online Attitudes Toward COVID-19 Vaccines: Year-long Longitudinal and Cross-sectional StudyObservational Study Published on 2022-01-212022-10-04 Journal: Journal of Medical Internet Research [Category] SARS, 임상, [키워드] accelerate age Algorithm alleviate Analysis Attitude can be used caused Characteristics collected concerning conducted confirmed case correlated COVID-19 COVID-19 pandemic COVID-19 vaccine Critical cross-sectional Data mining deaths deep learning defined demographic characteristics dimension disparity Efficacy events Evolution expressed Government group groups help individual longitudinal male males mechanism media objective Older organization pandemic Pearson population group promote public health public health authority Result second suggested targeted intervention Twitter urgency Vaccine Vaccines [DOI] 10.2196/32394 PMC 바로가기 [Article Type] Observational Study