Effects of dapagliflozin on prevention of major clinical events and recovery in patients with respiratory failure because of COVID-19: Design and rationale for the DARE-19 studyCOVID-19로 인한 호흡 부전 환자의 주요 임상 사건 예방 및 회복에 대한 다파글리플로진의 효과: DARE-19 연구의 설계 및 근거Article Published on 2021-04-012022-09-11 Journal: Diabetes, obesity & metabolism [Category] SARS, 임상, [키워드] 1:1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Adult patients all-cause mortality atherosclerotic benefit cardiometabolic cardiometabolic risk factor cardiovascular cardiovascular disease caused Chronic kidney disease clinical recovery clinical status clinical trial composite endpoint coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 complications COVID-19-related complication COVID-19-related complications Critically ill Dapagliflozin diabetes double-blind Effect Efficacy Eligible patients Endpoint evaluate event Glucose heart failure Hierarchical high-risk patient High-risk patients Hospitalization hypothese IMPROVE incidence individuals with COVID-19 inhibitor International investigator-initiated kidney Kidney disease Kidney injury material morbidity and mortality multicentre multiorgan failure organ organ dysfunction Patient patient population patients hospitalized patients with COVID-19 phase III study Placebo placebo-controlled study Prevent Randomized Randomized controlled trial randomized trial reduce respiratory complication Respiratory complications Respiratory failure Safety safety profile SGLT2 inhibitor shown sodium Treatment type 2 diabete type 2 diabetes with COVID-19 worsened [DOI] 10.1111/dom.14296 PMC 바로가기 [Article Type] Article
Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infectionSARS-CoV-2 감염 환자 7,995명의 임상적 특징 및 결과Research Article Published on 2021-03-312022-09-12 Journal: PLoS ONE [Category] MERS, 진단, [키워드] 95%CI acute respiratory syndrome Admission Adult patients age association Black race Characteristics clinical Clinical data Community Comorbidities Comorbidity determined by discharge discharged patient discharged patients disease disease severity ethnic group Ethnic groups evaluate expired feature health system Hispanic ethnicity identify in-hospital mortality Increased Infection Invasive mechanical ventilation Male sex measure median age Mortality New not significantly different objective observational study Older age outcome Patient patient population patients patients with SARS-CoV-2 PCR testing Population positive Primary outcomes Racial real-world data Repository required Respiratory Support Result Retrospective study risk risk factor Risk factors RT-PCR testing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 testing setting severe acute respiratory syndrome virus study period tested treatment guidelines virus while [DOI] 10.1371/journal.pone.0243291 PMC 바로가기 [Article Type] Research Article
Characteristics and outcomes in hospitalized COVID-19 patients during the first 28 days of the spring and autumn pandemic waves in Milan: An observational prospective study밀라노의 봄과 가을 유행성 파도의 첫 28일 동안 입원한 COVID-19 환자의 특성 및 결과: 관찰 전향 연구Observational Study Published on 2021-03-012022-09-11 Journal: Respiratory medicine [Category] 임상, 치료제, [키워드] Administered Adult patients anticoagulation Changing Characteristics Clinical studies comparable Corticosteroid Corticosteroids COVID-19 COVID-19 patients COVID-19 pneumonia CPAP D-dimer Dexamethasone discharged home distress Effect enoxaparin FEU Healthcare system Hospital mortality Hospital stay hospitalized COVID-19 patient hospitalized COVID-19 patients Hydroxychloroquine in-hospital mortality initiated International intubation Italy Lopinavir Lopinavir/ritonavir males material Methylprednisolone Mortality observational study outcome oxygen oxygen mask oxygen masks pandemic Patient patients hospitalized Pneumonia proportion Prospective Study recommendations reduced regimen Remdesivir respiratory respiratory distress Respiratory failure Ritonavir severe pneumonia severe respiratory failure systemic corticosteroid systemic corticosteroids therapeutic Therapeutic approach Thromboprophylaxis thrombosis Treatment were given with COVID-19 [DOI] 10.1016/j.rmed.2021.106323 PMC 바로가기 [Article Type] Observational Study
Effect of dexamethasone in patients with ARDS and COVID-19 – prospective, multi-centre, open-label, parallel-group, randomised controlled trial (REMED trial): A structured summary of a study protocol for a randomised controlled trialARDS 및 COVID-19 환자에서 덱사메타손의 효과 – 전향적, 다기관, 공개 라벨, 병렬 그룹, 무작위 대조 시험(REMED 시험): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-03-012022-09-10 Journal: Trials [Category] SARS, 임상, 치료기술, [키워드] (C-reactive protein 24 hour 24 hours administration adrenal gland Adult patients Adverse adverse events age alcohol allergy allocation Antigen ARDS ARDS patients ARMS assumed Barthel Index benzyl alcohol Berlin Berlin criteria Blinding Block randomisation Brazil Breastfeeding C-reactive protein calculated can be used Cardiac arrest Care carried case report form CCI Charlson Comorbidity Index Chemotherapy clinical Comorbidity comparator completion condition conducted consequence Contraception control group Corticosteroid Corticosteroids COVID-19 COVID-19 ARDS patient criteria CRP current Czech Republic Day decision defined detect Dexamethasone dexamethasone 6 mg diagnosed dissemination dose doses Dynamics eCRF Effect Effectiveness Efficacy and safety electronic case report form element eligible Endpoint enrolled enrolment EudraCT evaluate event expected exploratory Factor followed by French gastrointestinal bleeding HFNC hospital hospital discharge Hospital stay hypersensitivity Hypothesis ICU ICU admission ICUs Identifier Immunosuppression immunosuppressive drug immunosuppressive drugs Independence independent independent of Infection infections Inflammatory infusion intensive care unit intensive care units Intervention intervention group intractable intravenously intubate intubation investigational medicinal product investigator investigators Laboratory life malignancy marker mechanical ventilation medical history moderate moderate to severe Mortality nasal nasal cannula number objective observational study once daily Open-label open-label trial outcome oxygen Oxygen therapy PaO parallel-group participant Participation Patient patients with ARDS patients with moderate performed power power of 80% Pragmatic Pregnancy present primary efficacy endpoint primary endpoint protocol Quality of life randomisation randomised randomised controlled trial receive recruitment Registered routine clinical practice RT-PCR Sample size scale secondary Secondary endpoints Septic shock sequence severe ARDS sexual abstinence solution Standard deviation statistical analysis statistician status Stratification stratified Study protocol superinfection supplementary material systemic systemic corticosteroids thrombotic Thrombotic complications title Treatment treatment arm Trial Trial registration two-sided type I type I error university hospital Ventilation ventilator-free day Ventilator-free days Version VFD website WHO [DOI] 10.1186/s13063-021-05116-9 PMC 바로가기 [Article Type] Letter
Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study급성 코로나19 이후 증후군. 발병률 및 위험 요인: 지중해 코호트 연구Article Published on 2021-03-012022-09-11 Journal: The Journal of Infection [Category] SARS, 치료기술, [키워드] 95%CI Abnormalities abnormality acute infection Adult patients alteration analyzed Associated factors baseline change chest radiology clinical feature clinically cohort study components COVID-19 COVID19 defined Diagnostic imaging disease onset evaluate evaluated form health-related quality of life incidence independent predictor independent predictors IQR less life life quality Logistic regression Mild multiple logistic regression Patient patients PCR persistence predictor prospective cohort study Radiographs risk Risk factors SARS-COV-2 infection Sequelae Seroconversion Seven spirometry subsequent Survivors Symptom Symptoms syndrome [DOI] 10.1016/j.jinf.2021.01.004 PMC 바로가기 [Article Type] Article
Thirty-day readmission rate of COVID-19 patients discharged from a tertiary care university hospital in Turkey: an observational, single-center study터키의 3차 치료 대학 병원에서 퇴원한 COVID-19 환자의 30일 재입원률: 관찰, 단일 센터 연구Observational Study Published on 2021-02-202022-09-11 Journal: International journal for quality in health care : [Category] 임상, 치료기술, [키워드] 2019 30-day readmission rate Adult patient Adult patients age Cancer cancers Care cause causes Clinical data coronavirus coronavirus disease COVID-19 COVID-19 patient database detect Diagnosis diagnosis of COVID-19 died discharge discharged disease Factor health information Health information system hospital Hospitalized hypertension information information management Information System interquartile range malignancy management median time metastatic cancers Mild Mild disease moderate Moderate COVID-19 moderate disease Patient patient information patient safety predictor readmission readmission. Research retrieved Sepsis severity single-center study System the patient Two patient two patients university hospital was recorded [DOI] 10.1093/intqhc/mzaa144 PMC 바로가기 [Article Type] Observational Study
Observational study of haloperidol in hospitalized patients with COVID-19코로나19로 입원한 환자를 대상으로 한 할로페리돌의 관찰 연구Clinical Trial Published on 2021-02-192022-08-13 Journal: PLoS ONE [Category] MERS, 임상, 치료제, [키워드] 48 hour 48 hours 95% CI Admission Adult patients analyses Analysis antipsychotic Antiviral effect AP-HP assistance association baseline Characteristics Composite COVID-19 death defined discharge home discharged home dose endpoints examined finding Follow-up haloperidol Hospital admission hospitalized patient hospitals In-vitro Inpatient intubation multicenter observational study multiple sensitivity analyses multivariable Cox regression observational study occurred outcome over Paris Patient patients hospitalized patients with COVID-19 PCR test per day positive COVID-19 primary end-point primary endpoint Probability psychotropic medications receiving receptor receptor antagonist Result risk SARS-CoV-2 secondary endpoint Sensitivity analyses suggested survivor univariate Cox regression university Weighting with COVID-19 [DOI] 10.1371/journal.pone.0247122 PMC 바로가기 [Article Type] Clinical Trial
Clinical characteristics of adult patients hospitalized with laboratory-confirmed COVID-19 pneumonia실험실에서 확인된 COVID-19 폐렴으로 입원한 성인 환자의 임상적 특징Article Published on 2021-02-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome Adult patients analyzed asymptomatic infection case sery Characteristics clinical Clinical characteristics Comorbidity coronavirus cough country COVID-19 COVID-19 pneumonia CRP diabetes Diabetes Mellitus died discharged Elderly patient elderly patients elevated eventually death Fever followed by heart disease heterogeneity hypertension ischemic heart disease İstanbul laboratory-confirmed leukopenia lymphocytopenia mortality rate mortality rates Outbreaks outcome overall mortality Patient patient cohort patient cohorts patients patients hospitalized patients with COVID-19 Pneumonia provide respiratory distress Retrospective study Shortness of breath single-center Symptom syndrome Treatment strategies Turkey Variation [DOI] 10.1016/j.jiac.2020.10.020 PMC 바로가기 [Article Type] Article
High D dimers and low global fibrinolysis coexist in COVID19 patients: what is going on in there?높은 D 이량체와 낮은 글로벌 섬유소 용해는 COVID19 환자에서 공존합니다. 거기에서 무슨 일이 일어나고 있습니까?Clinical Trial Published on 2021-02-012022-09-11 Journal: Journal of Thrombosis and Thrombolysis [Category] SARS, 임상, 치료기술, [키워드] Adult patient Adult patients approval calculated characterized clinical clot Coagulation coagulation test Coagulopathy correlation Course COVID COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients COVID19 D dimer D-dimer D-dimer level D-dimer levels detect diagnosed with COVID-19 Disseminated intravascular coagulation England enrolled ethics committee fibrinogen fibrinolysis fibrinolytic high mortality hypercoagulable Hypercoagulable state Hypothesis ICU ICU admission increase in Inpatient intravascular coagulation Laboratory Lancet London lung Lungs marker median morbidity Mortality normal range occur Organ failure paradoxical parameter Patient performed pilot study Platelet Platelet count retrospective cohort study risk factor Risk factors sample collection Sepsis sepsis-induced coagulopathy Septic shock Sequential Organ Failure Assessment Severe COVID-19 Infection severely ill COVID-19 patients SOFA SOFA score therapeutic anticoagulation Thromboelastometry thromboembolic Thromboembolic event Thromboembolic events Venous Thromboembolism were excluded while with COVID-19 Wuhan [DOI] 10.1007/s11239-020-02226-0 PMC 바로가기 [Article Type] Clinical Trial
Association between markers of immune response at hospital admission and COVID-19 disease severity and mortality: A meta-analysis and meta-regression입원 시 면역 반응 지표와 COVID-19 질병 중증도 및 사망률 간의 연관성: 메타 분석 및 메타 회귀Meta-Analysis Published on 2021-02-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 바이오마커, [키워드] 95% CI 95% confidence interval Adaptive immune response Admission Adult patients age age and sex ALC ANC articles association C-reactive protein C-reactive protein (CRP calculate candidate Coagulation conducted coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 disease severity D-dimer determine disease severity ferritin groups highlight Hospital admission hospitalized COVID-19 patient hospitalized COVID-19 patients hyper inflammation identify IL-6 immune response inclusion criteria interleukin interleukin-6 Intervention intravascular coagulation Laboratory laboratory values LDH lymphocyte Lymphocytes marker material mean difference Meta-analysis meta-regression Mortality neutrophil Neutrophils Pathogenesis pathogenesis of COVID-19 Patient patients random effect sensitivity Sex statistically significant subsequent systematic review the WHO troponin I utility was used [DOI] 10.1002/jmv.26411 PMC 바로가기 [Article Type] Meta-Analysis