Antiviral agents – Page 10 – Communicable Diseases Research

Possible Role of Matrix Metalloproteinases and TGF-β in COVID-19 Severity and Sequelae

COVID-19 중증도 및 후유증에서 기질 금속단백분해효소 및 TGF-β의 가능한 역할

Review

Published on 2022-08-012022-09-11
Journal: Journal of interferon & cytokine research : the of [Category] COVID19(2023년), SARS, 바이오마커,

Binding of synthetic carbohydrate receptors to enveloped virus glycans: Insights from molecular dynamics simulations

Article

Published on 2022-08-012023-07-09
Journal: Carbohydrate Research [Category] COVID19(2023년),

[키워드] Antiviral agents glycans molecular dynamics simulations Supramolecular chemistry viruses
[DOI] 10.1016/j.carres.2022.108574 PMC 바로가기

The Possible Role of Prion-Like Viral Protein Domains on the Emergence of Novel Viruses as SARS-CoV-2

SARS-CoV-2와 같은 새로운 바이러스의 출현에 대한 프리온 유사 바이러스 단백질 도메인의 가능한 역할

Article

Published on 2022-08-012022-09-11
Journal: Journal of molecular evolution [Category] COVID19(2023년), SARS, 치료제,

Real-life data on monoclonal antibodies and antiviral drugs in Italian inborn errors of immunity patients during COVID-19 pandemic

코로나19 팬데믹 기간 동안 이탈리아 선천성 면역질환 환자의 단클론항체 및 항바이러스제 실생활 데이터

Article

Published on 2022-07-282022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료제,

[키워드] Alpha Analysis Antiviral antiviral agent Antiviral agents antiviral drug antiviral drugs Asymptomatic Care circulating Cohort contributed Course COVID-19 COVID-19 pandemic COVID-19 severity disease disease severity duration of viral shedding Effect Efficacy error evaluated Hospital admission Hospitalization hospitalization-risk hospitalizations hospitalized patients ICU admission Immunity immunized Inborn Inborn errors inborn errors of immunity Infection Italian longitudinal lower risk mAbs mitigate monoclonal monoclonal antibodies monoclonal antibody Mortality mRNA vaccine mRNA vaccines offered Patient patients treated performed positive Prevent prophylactic measure prophylactic measures Re-infection Re-infections reduce reduced Reinfection reported respond risk Safe SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 positivity SARS-CoV-2 strains SARS-CoV-2 virus severe COVID-19 severe disease Spectrum Spread Strains therapeutic therapy treated vaccination Vaccinations Viral viral shedding viral strain viral strains widespread
[DOI] 10.3389/fimmu.2022.947174 PMC 바로가기 [Article Type] Article

Developing New Treatments for COVID-19 through Dual-Action Antiviral/Anti-Inflammatory Small Molecules and Physiologically Based Pharmacokinetic Modeling

이중 작용 항바이러스/항염 소분자 및 생리학적 기반 약동학 모델링을 통한 COVID-19에 대한 새로운 치료법 개발

Review

Published on 2022-07-202022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 진단, 치료제,

[키워드] (dexamethasone Anti-inflammatory Anti-SARS-CoV-2 Activity Antiviral antiviral agent Antiviral agents approach Baricitinib biochemical pathway Biochemical pathways characterization COVID-19 COVID-19 pandemic Critical Cytopathic effect develop Developing Dexamethasone drug target dual dual action early treatment effective Efficacy and safety health system health systems High-risk patients identify in silico in vitro in vivo model Infection inflammatory cascade inhibitor inhibitors mechanism Mild mild to moderate Mild to moderate COVID-19 modeling Moderate COVID-19 molecular docking molecule molnupiravir monoclonal antibodies multidisciplinary approach New Nirmatrelvir pandemic pathogen PBPK modeling pharmacological protocol Ritonavir therapeutic agent therapeutic agents threat Treatment treatment of COVID-19 Viral virus viruses
[DOI] 10.3390/ijms23148006 PMC 바로가기 [Article Type] Review

Potential COVID-19 Therapies from Computational Repurposing of Drugs and Natural Products against the SARS-CoV-2 Helicase

SARS-CoV-2 헬리카제에 대한 약물 및 천연물의 전산 용도 변경으로 인한 잠재적인 COVID-19 치료법

Article

Published on 2022-07-122022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 신약개발, 치료제,

[키워드] analgesic anticancer Anticoagulant Antihistamine Antihistamines Antiviral agents antivirals antrafenine applied approach aprepitant AutoDock vina binding energy cabotegravir calculate COVID-19 COVID-19 therapy COVID-19 treatments dicoumarol drug Drug repurposing drugs epirubicin Evidence fexofenadine Helicase in silico in vitro in vivo molecular molecular docking molecular dynamics natural non-structural protein nsp13 Potential potential COVID-19 treatments product Protein reported Repurposed drug Repurposed drugs repurposing RSV-604 SARS-CoV-2 Screen tandem the SARS-CoV-2 Treatment Virtual screening
[DOI] 10.3390/ijms23147704 PMC 바로가기 [Article Type] Article

A novel inactivated virus system (InViS) for a fast and inexpensive assessment of viral disintegration

바이러스 분해에 대한 빠르고 저렴한 평가를 위한 새로운 불활성화 바이러스 시스템(InViS)

Article

Published on 2022-07-082022-09-11
Journal: Scientific Reports [Category] 치료제,

Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture

TMPRSS2의 펩티드모방 억제제는 세포 배양에서 SARS-CoV-2 감염을 차단합니다

Article

Published on 2022-07-082022-09-11
Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제,

[키워드] antiviral agent Antiviral agents Blood camostat Camostat mesylate candidate catalytic site Cell culture clinical development Coagulation comparable Compound COVID-19 COVID-19 therapy Delta Efficacy electrophilic host cell in silico in vitro inhibit inhibit SARS-CoV-2 inhibitors of TMPRSS2 molecular docking studies Molecular docking study omicron plasma Prevent Proteases Protein pseudovirus entry SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant selected Serine serum and plasma spike target the SARS-CoV-2 therapy TMPRSS2 TMPRSS2 inhibitor TMPRSS2 inhibitors transmembrane serine protease transmembrane serine protease 2 TRAP viruses
[DOI] 10.1038/s42003-022-03613-4 PMC 바로가기 [Article Type] Article

Computational investigation of benzalacetophenone derivatives against SARS-CoV-2 as potential multi-target bioactive compounds

SARS-CoV-2에 대한 벤잘아세토페논 유도체의 잠재적 다중 표적 생리활성 화합물의 전산 조사

Article

Published on 2022-07-012022-09-11
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 치료제,

[키워드] 3CL pro 3CL(pro) addition Anti-SARS-CoV-2 Activity Antiviral antiviral activities Antiviral agents AutoDock Benzalacetophenones binding affinity binding energy binding free energy biological processes Candidates cellular components Compound COVID-19 derivative develop Diseases domain down-regulated enrichment analysis evaluated FIVE flavonoids free energy highest highest binding affinity identify Immune boost immune system Immunity immunostimulant Interaction lab modulated modulation molecular molecular docking molecular dynamics Molecular dynamics simulation molecular functions Molecular mechanics multiple pathway multiple pathways network network pharmacology nine non-infectious Papain Papain-like protease pathway Pathways Patient pharmacological PL(pro) precursor precursors protease Protein recorded reflected regulated retrieved SARS-CoV-2 scored screened Simulation spike Spike protein surface area target upregulated was performed
[DOI] 10.1016/j.compbiomed.2022.105668 PMC 바로가기 [Article Type] Article

Development and optimization of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: Evaluation of 5676 Phase 1 Passed Structures

시험관내 항SARS-CoV-2 활성에 대한 고처리량 스크리닝 분석의 개발 및 최적화: 5676 1상 통과 구조 평가

Clinical Trial

Published on 2022-07-012022-09-11
Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 임상, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus African green monkey anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral Antiviral agents Caco-2 can not cell lines Chloroquine clinical development clinical trials clinically Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 treatment development Doxorubicin drug effective enhanced green fluorescent protein epithelial cell epithelial cells expressing fluorescent green fluorescent protein green monkey Hydroxychloroquine in vitro inhibitor inhibitors itraconazole kidney library nelfinavir outbreak pandemic pharmacokinetic data Phase 1 Protein Remdesivir SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection strain Strains Structure Support these compound these compounds Toxicity Treatment Vaccine Vaccines VeroE6-eGFP cells virus was used
[DOI] 10.1002/jmv.27683 PMC 바로가기 [Article Type] Clinical Trial