Protective Role of Combined Polyphenols and Micronutrients against Influenza A Virus and SARS-CoV-2 Infection In VitroArticle Published on 2021-11-192022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] acute respiratory syndrome analyzed anti-inflammatory property antiviral activity Antiviral effect antiviral efficacy antivirals Combined coronavirus COVID-19 cytokine production demonstrated Efficacy evaluated expression IL-6 Infection Influenza Influenza virus inhibit inhibiting inhibitory effect mechanism Micronutrient micronutrients Polydatin polyphenol polyphenols post infection precursor reduced Replication replicative respiratory virus Respiratory virus infections resveratrol role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections significantly tested Treatment Vero E6 cell Viral protein virus virus-infected cells [DOI] 10.3390/biomedicines9111721 PMC 바로가기 [Article Type] Article
In Vitro Replication Inhibitory Activity of Xanthorrhizol against Severe Acute Respiratory Syndrome Coronavirus 2Article Published on 2021-11-192022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] 3CL activity acute respiratory syndrome Antiviral Antiviral effect antiviral efficacy Cell clade clinical trial coronavirus coronavirus 2 Coronaviruses CoV replication COVID-19 pandemic CoVs Curcuma direct-acting antiviral drug enzymatic activity function had no Helicase hepatitis C virus herbal medicine human coronavirus in vitro Infection inhibit inhibited inhibitory management mechanism noroviruses pan-coronavirus antivirals polymerase predominant protease reduced Replication respiratory RNA SARS-CoV-1 SARS-CoV-2 therapeutic option variants variants of concern Viral RNA while xanthorrhizol [DOI] 10.3390/biomedicines9111725 PMC 바로가기 [Article Type] Article
Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral MechanismsCurcumin은 다중 항바이러스 메커니즘을 통해 Vero E6 세포의 시험관 내 SARS-CoV-2 감염을 억제합니다Article Published on 2021-11-162022-09-10 Journal: Molecules [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제, [키워드] addition Affect anti-inflammatory effect anti-inflammatory property Antiviral antiviral activity Antiviral effect COVID-19 Curcumin Cytokines cytotoxicity D614G D614G strain delta variant ELISA evaluated exhibit exhibited IL-1β IL-6 IL-8 immune response in vitro independent Infection Inflammation inhibited investigated mononuclear cell mononuclear cells MTT Multiple PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells Plaque assay Post-infection pro-inflammatory cytokine pro-inflammatory cytokines qPCR quantified released replicative required SARS-CoV-2 SARS-COV-2 infection scarcity the SARS-CoV-2 Therapeutic approach therapeutic approaches to define Treatment treatment strategy triggered Vero E6 VERO E6 cells Viral viral titer virucidal were used [DOI] 10.3390/molecules26226900 PMC 바로가기 [Article Type] Article
The in vitro and in vivo efficacy of CT-P59 against Gamma, Delta and its associated variants of SARS-CoV-2SARS-CoV-2의 감마, 델타 및 관련 변이체에 대한 CT-P59의 시험관내 및 생체내 효능Article Published on 2021-11-122022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] abrogation antibody Antiviral effect Beta beta variants carried cause Cell cells CT-P59 Delta delta variant effective Efficacy Epsilon experiment experiments Gamma in vitro in vivo Infection infections L452R neutralization Patient question reduced regdanvimab remains uncertain reported respiratory respiratory tract SARS-CoV-2 SARS-CoV-2 variant susceptibility Symptom Therapeutic antibody. therapeutic potential variant variants variants of SARS-CoV-2 virus [DOI] 10.1016/j.bbrc.2021.09.023 PMC 바로가기 [Article Type] Article
Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction헴 옥시게나제-1 유도를 통한 코로나19 치료의 새로운 후보인 헤민Article Published on 2021-11-022022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antimicrobial therapy antiviral activity Antiviral effect antiviral effects Biliverdin byproduct causative agent cells coronavirus coronavirus disease Coronavirus disease-19 COVID-19 death rate effective enzyme expression expression vector Free growth heme hemin in vitro inducer Inflammatory response inhibit investigated iron oxidative stress Protein reduce reported respiratory restrict Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selectivity index severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suggested suppresse suppressed therapeutic transient expression treating COVID-19 Treatment Viral viral infection viral infections virus [DOI] 10.1038/s41598-021-01054-3 PMC 바로가기 [Article Type] Article
Antiviral effects of human placenta hydrolysate (Laennec ®) against SARS-CoV-2 in vitro and in the ferret model시험관 내 및 흰 족제비 모델에서 SARS-CoV-2에 대한 인간 태반 가수분해물(Laennec®)의 항바이러스 효과Comparative Study Published on 2021-11-012022-09-11 Journal: Journal of microbiology (Seoul, Korea) [Category] SARS, 치료제, [키워드] addition Antiviral Antiviral effect antiviral effects antiviral efficacy Attenuated Virus caused clinical manifestation COVID-19 COVID-19 pandemic COVID-19 treatment cytokine Cytokines determine determined by disease dose-dependent manner Effect effective FDA-approved drug ferret ferrets Gene Expression group Health health condition Human Hyperferritinemia IFN IFN-α IFN-β IFN-γ IMPROVE in vitro in vivo model Infection inhibited interferon Laennec® lung Lungs MOI mRNA expression nasal Patient PBS Placenta qRT-PCR Remdesivir respiratory tract respiratory tracts Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selective shown TCID therapeutic therapeutic agent treated Treatment type I upregulated Vero Cell Vero cells virus replication virus titer virus titers was determined [DOI] 10.1007/s12275-021-1367-2 PMC 바로가기 [Article Type] Comparative Study
Effects of dyslipidemia on E antigen seroconversion of patients with chronic hepatitis B treated by nucleoside (acid) analogsResearch Published on 2021-10-302023-06-03 Journal: Lipids in Health and Disease [Category] B형 간염, [키워드] Antiviral effect Chronic Hepatitis B dyslipidemia Nucleoside (acid) analogs [DOI] 10.1186/s12944-021-01582-x PMC 바로가기 [Article Type] Research
Antiviral Activity and Underlying Action Mechanism of Euglena Extract against Influenza VirusArticle Published on 2021-10-302023-06-08 Journal: Nutrients [Category] Fulltext, 신종인플루엔자, [키워드] Euglena gracilis Antiviral effect Euglena extract Influenza virus Zinc [DOI] 10.3390/nu13113911 PMC 바로가기 [Article Type] Article
Natural Apocarotenoids and Their Synthetic Glycopeptide Conjugates Inhibit SARS-CoV-2 ReplicationArticle Published on 2021-10-302022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] β-apocarotenoic acid Anti-SARS-CoV-2 Activity antibacterial activity antibiotic Antiviral antiviral activity Antiviral effect approved bixin cathepsin B cathepsin L Cell clinically colorant Compound computational studies conjugate COVID-19 pandemic Crocetin drug Efficacy inhibitory action inhibitory activity involved modifications natural protease quantitative PCR ristocetin SARS-CoV-2 synthetic Teicoplanin VERO E6 cells viability viral replication Viral RNA was tested [DOI] 10.3390/ph14111111 PMC 바로가기 [Article Type] Article
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery항바이러스 약물 발견을 위한 SARS-CoV-2-호스트 프로테옴 상호작용Article Published on 2021-10-282022-09-10 Journal: Molecular Systems Biology [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] addition Affinity purification analyses Analysis antiviral activity antiviral drug Antiviral effect antiviral effects applied approach biological significance candidate drug caused cofactor cofactors complementary Compound COVID‐19 criterion Critical develop downstream drug Drug discovery effective therapy Host host cell host cell proteases host protein host proteins hub protein identify in viral inhibitory effect Interaction labeling list mass spectrometry methotrexate Microbiology, Virology & Host Pathogen Interaction molecular ORF Pharmacology & Drug Discovery protein targets protein–protein interactions proteome proteomics provided receptors Replication resource SARS‐CoV‐2 SARS‐CoV‐2 suggested understanding Viral viral pathogenesis viral replication Virtual screening virus–host interactions [DOI] 10.15252/msb.202110396 PMC 바로가기 [Article Type] Article