blockade
[용어속성] Term
A mechanism for matrikine regulation in acute inflammatory lung injury
급성 염증성 폐 손상에서 마트리킨 조절 메커니즘
Research Article
[키워드] acetylated
Acute inflammation
acute lung injury
airway epithelia
animal
animals
BAL
blockade
Bronchoalveolar lavage
cefadroxil
chronic inflammatory disease
clinical sample
clinical samples
coculture
collagen
competitive inhibitor
Concentration
COVID-19
Degradation
determine
Extracellular matrix
extrapulmonary sites
glycine
in vitro
in vivo
Inflammation
inflammatory lung injury
inhibitor
intratracheal
intratracheal instillation
knockdown
knowledge
LPS-induced lung injury
lung
Lung inflammation
Lung injury
lung tissue
mechanism
modulating
mouse model
neutrophil
neutrophil chemoattractant
Neutrophils
Patient
peptide
peptides
PGP
potential therapeutic target
proline
redistribution
reduced
Regulation
shown
significantly
Transport
transported
[DOI] 10.1172/jci.insight.140750 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1172/jci.insight.140750 PMC 바로가기 [Article Type] Research Article
A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling
Research Article
[키워드] Activation
Alpha
antibody
AOSD, adult-onset Still's disease
bind
blockade
Candida albican
characterized
complex
COVID-19
COVID-19 patient
COVID-19 patients
cultures
Cytokine storm
Diseases
downstream
DSS, dextran sodium sulfate
elevated
exhibiting
high mortality
human cell lines
humanized
IBD, Inflammatory bowel disease
IFNγ
IFNγ
IL-1
IL-1 receptor 7 (IL-1R7)
IL-18
IL-18, interleukin-18
IL-6
Inflammation
inflammatory signaling
inhibited
initiate
Interleukin-18
interleukin-18 (IL-18)
LPS
macrophage activation syndrome
macrophage activation syndrome (MAS)
MAS, macrophage activation syndrome
modulate
monoclonal
mononuclear cell
NFκB
PBMC, peripheral blood mononuclear cell
PBMCs
Peripheral blood
Proinflammatory cytokine
receptor
recruitment
reduce
reduced
resulting
severe disease
severity of COVID-19
sHLH, secondary hemophagocytic lymphohistiocytosis
Signaling
significantly
suppressed
Symptoms
systemic and local
systemic hyperinflammation
therapeutic
therapeutic strategy
TIR, Toll-IL-1 receptor
TNFα
TNSB, trinitrobenzoic sulfonic acid
Whole blood
[DOI] 10.1016/j.jbc.2021.100630 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1016/j.jbc.2021.100630 PMC 바로가기 [Article Type] Research Article
Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions
다학제적 접근 방식으로 SARS-CoV-2–ACE2 수용체 상호작용을 차단하는 후보로서 인간 ACE2 또는 SARS-CoV-2 스파이크 단백질에 결합하는 화합물 식별
Research Article
[키워드] ACE2
acute respiratory syndrome
acute respiratory syndrome coronavirus
angiotensin
angiotensin converting enzyme
angiotensin converting enzyme 2
Antiviral
bind
binding
block
blockade
candidate
causative agent
cause
caused
cellular receptor
Compound
compounds
coronavirus
COVID-19
death
demonstrated
Diseases
Dissociation constant
dose-dependent
drug
Drug development
Drug screening
dual
entry inhibitors
enzyme
evaluate
Evans blue
Human
human ACE2
identify
in vitro
Infection
Infectious disease
inhibitor
Interaction
interfere
Intervention
library
lifitegrast
lumacaftor
molecular docking
Protein
RBD
RBD binders
RBD-ACE2
receptor
Receptor binding domain
Registered
repurposing
respiratory
SARS-CoV-1
SARS-CoV-2
SARS-CoV-2 entry
SARS-COV-2 infection
SARS-CoV-2 RBD
SARS-CoV-2 spike glycoprotein
SARS-CoV-2 spike protein
SARS-CoV-2 spike protein receptor binding domain
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
sodium
spike
spike glycoprotein
Spike protein
SPR
surface plasmon
surface plasmon resonance
targets
the RBD
the SARS-CoV-2
these compounds
VERO-E6
virus
was used
[DOI] 10.1128/mBio.03681-20 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1128/mBio.03681-20 PMC 바로가기 [Article Type] Research Article
Policy disparities in response to the first wave of COVID-19 between China and Germany
Research
[키워드] adopted
analyzed
association
blockade
center
China
confirmed case
Control
country
Coverage
COVID-19
crisis
cumulative
Epidemics
evaluate
Factor
First wave
Generalized linear model
Germany
Global health equity
group
highest
Johns Hopkins University
National Health Commission
nonpharmaceutical intervention
novel
objective
Policy
prevention
PROTECT
protocol
provided
public health
reduce
reduce mortality
Research
Result
risk
School
source of infection
virus
[DOI] 10.1186/s12939-021-01424-3 PMC 바로가기 [Article Type] Research
[DOI] 10.1186/s12939-021-01424-3 PMC 바로가기 [Article Type] Research
The impact of the coronavirus disease and Tele-Heart Failure Clinic on cardiovascular mortality and heart failure hospitalization in ambulatory patients with heart failure
Research Article
[키워드] ambulatory patient
blockade
cardiovascular
Care
chose
clinic
Cohort
continuum
coronavirus disease
COVID-19 pandemic
database
death
declined
dose
Ejection fraction
failure
heart
heart failure
Hospitalization
less
Mortality
neurohormonal
not affect
pandemic
Patient
readmission
reduced
reduction in
rehospitalization
Result
significantly
significantly lower
subsequent
Therapies
[DOI] 10.1371/journal.pone.0249043 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pone.0249043 PMC 바로가기 [Article Type] Research Article
Anti-IL5 Drugs in COVID-19 Patients: Role of Eosinophils in SARS-CoV-2-Induced Immunopathology
Pharmacology
[키워드] Activation
addition
airway
anti-IL5 drugs
Asthma
asthmatic patient
biological drug
blockade
bronchial asthma
complex
contribute
Corticosteroids
COVID-19
Critical
Cytokines
decrease
Defense
demonstrated
drug
eosinophil
eosinophils
equipment
facilitate
growth
hospitalized patients
IL-5
immune response
immune system
Immunity
immunopathology
Infection
inhibitors
interleukin-5
Peripheral blood
progression
reduce
respiratory viruses
risk factor
role
SARS-COV-2 infection
severe COVID-19
severe COVID-19 patients
severe patients
Steroids
stimulate
stimulated
survival
T helper
the disease
treated
Type
type 2 response
viral replication
[DOI] 10.3389/fphar.2021.622554 PMC 바로가기 [Article Type] Pharmacology
[DOI] 10.3389/fphar.2021.622554 PMC 바로가기 [Article Type] Pharmacology
1,2,3,4,6-Pentagalloyl Glucose, a RBD-ACE2 Binding Inhibitor to Prevent SARS-CoV-2 Infection
Pharmacology
[키워드] 1, 2, 3, 4, 6-pentagalloyl glucose
ACE2
addition
adopted
Antiviral
bind
binding
binding affinity
binding domain
binding energy
BLI
block
blockade
caused
cellular
confirmed COVID-19 case
country
COVID-19
determine
dose
drug
Efficacy
ELISA
exhibit
Face mask
global public health
Glucose
hACE2
HEK293 cells
human Angiotensin-converting enzyme
human host cells
immunized
immunocytochemistry
lentivirus
mice
molecular docking
molecular interaction
MTD
natural antiviral
outbreak
overexpressing
Protein
RBD
RBD-ACE2
RBD-ACE2 inhibitor
receptor
receptors
residue
responsible
Safe
SARS-CoV-2
SARS-CoV-2 vaccine
SARS-CoV-2 virus
SARS-CoV-2-RBD
the SARS-CoV-2
Vaccine
viral infection
wild type
[DOI] 10.3389/fphar.2021.634176 PMC 바로가기 [Article Type] Pharmacology
[DOI] 10.3389/fphar.2021.634176 PMC 바로가기 [Article Type] Pharmacology
At the Crossroads: COVID-19 and Immune-Checkpoint Blockade for Cancer
갈림길에서: COVID-19와 암에 대한 면역 관문 차단
Article
[키워드] acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
antiviral immune response
antiviral immune responses
blockade
Cancer
Characteristics
clinical trials
Complication
complications of COVID-19
coronavirus
coronavirus disease
Coronavirus disease 2019
Course
COVID-19
COVID-19 infection
COVID-19 pandemic
COVID-19 vaccination
death
decrease
detrimental
disease course
Effect
Evidence
expression
heterogeneity
immune responses
immunomodulatory effect
immunomodulatory effects
infections
Inflammatory
inflammatory complications
Inflammatory response
Inflammatory responses
interferon
interferon signaling
leads
Ligand
MOST
pathway
Patient
patients
Patients with cancer
PD-L1
PD1
PROTECT
provided
receiving
receptor
respiratory
respiratory distress
Respiratory distress syndrome
RNA virus
SARS-CoV-2
severe acute respiratory syndrome Coronavirus
Severe case
severe cases
Severe respiratory distress
Support
syndrome
the disease
therapy
Viral
viral infection
virus infections
worsening
[DOI] 10.1158/2326-6066.CIR-21-0008 PMC 바로가기 [Article Type] Article
[DOI] 10.1158/2326-6066.CIR-21-0008 PMC 바로가기 [Article Type] Article
Breadth and function of antibody response to acute SARS-CoV-2 infection in humans
인간의 급성 SARS-CoV-2 감염에 대한 항체 반응의 범위와 기능
Research Article
[키워드] ACE2
ACE2-blocking response
acute SARS-CoV-2 infection
acute viral infection
analysed
anti-non-RBD S1
Anti-RBD antibodies
Anti-RBD antibody
Anti-RBD MAb
Anti-RBD MAbs
anti-receptor-binding domain
anti-S2
Anti-spike
anti-spike MAbs
antibody
Antibody Response
Antibody responses
Antibody-mediated immunity
average
Betacoronavirus
binding
blockade
blocked
clone
Clusters
combinations
Complete
COVID-19 outbreak
COVID-19 patient
cross-react
elicited
epitope
Epitopes
expansion
Fever
FIVE
glycoprotein
Health
Human
human coronavirus
human coronavirus OC43
humans
Humoral response
IgG
Immunity
independent assays
mAbs
memory B cell
memory B cells
monoclonal antibody
neutralise
neutralising
Neutralising activity
Neutralising Antibodies
neutralising antibody
neutralising antibody response
non-overlapping epitope
non-overlapping epitopes
non-RBD S1
nucleocapsid
offer
outbreak
Patient
peripheral plasmablast response
plasmablast
plasmablast response
plasmablast responses
potent
Prolonged fever
Prophylactic
RBD
reactive
Receptor-binding domain
recovered patient
Region
responses
SARS-CoV-2
SARS-COV-2 infection
separate cluster
sera
serological
Serological and plasmablast responses
serology
somatic mutations
spike glycoprotein
subset
tested
the RBD
the receptor-binding domain
therapeutic agent
therapeutic agents
titre
Viral
viral infection
Virus spike
wild-type SARS-CoV-2
[DOI] 10.1371/journal.ppat.1009352 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009352 PMC 바로가기 [Article Type] Research Article