SARS-CoV-2 transmission and impacts of unvaccinated-only screening in populations of mixed vaccination statusSARS-CoV-2 전염 및 혼합 백신 상태의 인구에서 백신 접종만 하지 않은 검진의 영향Article Published on 2022-05-192022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] breakthrough infections category Community Coverage driven by effective Effectiveness evaluate hospitalizations Impact Infection mitigate omicron Population population immunity proportion reduction SARS-CoV-2 SARS-CoV-2 transmission Screening Spread Transmission transmission rates vaccination vaccination rate vaccination rates Vaccine variant [DOI] 10.1038/s41467-022-30144-7 PMC 바로가기 [Article Type] Article
Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2변종별 백신 접종은 시스템 면역 반응을 유도하고 SARS-CoV-2에 대한 강력한 생체 내 보호Article Published on 2022-05-172022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] animal models antibody B and T lymphocytes B.1.351 B.1.617 B.1.617.2 BCR Beta Beta variant breakthrough infections caused CD8 T cell clonal expansions COVID-19 vaccine Delta delta variant Delta variants Efficacy Gene Expression generate immune cell population immune cell populations immune profiling immune response immune responses in vivo induce Lineage Lipid Lipid nanoparticle LNP-mRNA Lymphocytes mRNA mRNA vaccination mRNA vaccines neutralization neutralization activity offer reactive SARS-CoV-2 SARS-CoV-2 spikes single-cell single-cell profiling Single-cell transcriptomics systems immunology T cell T cell response T cell responses T cells T lymphocytes TCR These data vaccination Vaccine variant variant-specific COVID-19 vaccine. variants virus viruses widespread wild-type [DOI] 10.1016/j.xcrm.2022.100634 PMC 바로가기 [Article Type] Article
Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study기계 학습 기반 병원 내 COVID-19 질병 결과 예측기(CODOP) 개발 및 평가: 다대륙 후향적 연구Article Published on 2022-05-172022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] allocation AUROC breakthrough infections calibrated Clinical outcome clinical parameter clinical utility clinically Cohort cohort of patient Computational biology country COVID-19 COVID-19 disease COVID-19 patient deaths development disperse effective heterogeneous hospital Hospital admission hospital resources Hospitalization hospitalizations hospitalized COVID-19 patients Human In-hospital Latin Latin America machine-learning maintain Medicine New offer outcome pandemic patient cohort patient cohorts prediction Predictive Retrospective study risk stratification SARS-CoV-2 variants sensitivity Spain specificity Systems biology tested Triage USA vaccination vaccination rate Vaccination Status variant virus waning immunity [DOI] 10.7554/eLife.75985 PMC 바로가기 [Article Type] Article
A multitope SARS-CoV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants멀티토프 SARS-CoV-2 백신은 Delta 및 Omicron 변이체에 대해 오래 지속되는 B 세포 및 T 세포 면역을 제공합니다Clinical Trial Published on 2022-05-162022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] adverse event Antibody titers Asia B cell booster Breakthrough infection breakthrough infections center conducted conserved Control COVID-19 cross-reactive cytotoxic T lymphocyte Delta disease control dose elicited epitope Epitopes evaluated fatigue healthy helper T cell Heterologous human convalescent sera Immunity immunization immunogenicity Inc. injection site pain long-lasting lymphocyte membrane memory immunity Mild Ministry of Health Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers Neutralizing titer nucleocapsid omicron Omicron variants peptide peptides Phase I placebo-controlled Protein provide Randomized representing responsible safety profile sarbecovirus SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants second dose Serious Adverse Event Serious Adverse Events subunit Subunit vaccine T cell Taiwan Trial trials Vaccine variant variants of SARS-CoV-2 virus-neutralizing antibody VOCs waning immunity Welfare were recorded [DOI] 10.1172/JCI157707 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 RT-qPCR testing of pooled saliva samples: A case study of 824 asymptomatic individuals and a questionnaire survey in Japan혼합된 타액 샘플의 SARS-CoV-2 RT-qPCR 테스트: 일본에서 824명의 무증상 개인을 대상으로 한 사례 연구 및 설문 조사Article Published on 2022-05-122022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] amplification asymptomatic individual Asymptomatic individuals Breakthrough infection breakthrough infections cold-like symptoms COVID-19 COVID-19 pandemic COVID-19 testing diagnostic employee evaluate exceeded had no Hospitalization individual Japan majority Non-invasive occurred participant Participants PCR PCR cycle PCR testing performed Philip positive positive individual proportion provided qPCR questionnaire recruited required RT-qPCR Saliva saliva samples Sample SARS-CoV-2 screening test submitted supply Support tested thought undergo variants [DOI] 10.1371/journal.pone.0263700 PMC 바로가기 [Article Type] Article
Defining SARS-CoV-2 breakthrough infection needing hospitalization in mass vaccination era: from disease-centered to patient-centered care대량 백신 접종 시대 입원이 필요한 SARS-CoV-2 돌발 감염 정의 : 질병 중심에서 환자 중심으로Article Published on 2022-05-112022-09-11 Journal: Acta bio-medica : Atenei Parmensis [Category] COVID19(2023년), SARS, 변종, [키워드] Breakthrough infection breakthrough infections Care Clinical course Clinical severity Comorbidities COVID-19 COVID-19-related symptom COVID-19-related symptoms Epidemiology hospital hospital care Hospitalization implementation IMPROVE increasingly Infection intrinsic mass vaccination measure number of comorbidities organization Patient Post-vaccine SARS-CoV-2 SARS-COV-2 infection subjects vaccination variants viral spread [DOI] 10.23750/abm.v93i2.12717 PMC 바로가기 [Article Type] Article
Trends and Correlates of Breakthrough Infections With SARS-CoV-2SARS-CoV-2를 통한 획기적인 감염의 추세 및 상관 관계Observational Study Published on 2022-05-102022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] acid acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age booster Breakthrough infection breakthrough infections Community coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccine efficacy COVID-19 vaccines decrease delta variant delta variant strain. effective Efficacy examined Factor female help individual infected individuals Infection infections janssen Observational cohort study occurred positive Probability receiving remained SARS-CoV-2 SARS-CoV-2 tests severe acute respiratory syndrome Coronavirus Spread subset trend two group two groups vaccinated individuals vaccination Vaccine variant were assessed white [DOI] 10.3389/fpubh.2022.856532 PMC 바로가기 [Article Type] Observational Study
Durable immunogenicity, adaptation to emerging variants, and low-dose efficacy of an AAV-based COVID-19 vaccine platform in macaquesArticle Published on 2022-05-102022-10-05 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] AAV acute respiratory syndrome adeno-associated virus approval breakthrough infections consequence Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 vaccine cynomolgus macaque dose Durability Effective vaccines Efficacy elicit genetic vaccine greater Health Immunity IMPROVE injection lack low-dose macaque maintain mice Neutralizing antibody response non-human primate non-human primates other variant platform preventative vaccine PROTECT reduced Safe SARS-CoV-2 shown single dose the epidemic Vaccine vaccine antigen vaccine candidate variants variants of concern viral challenge virus [DOI] 10.1016/j.ymthe.2022.05.007 [Article Type] Article
Breakthrough SARS-CoV-2 infections after COVID-19 mRNA vaccination in MS patients on disease modifying therapies during the Delta and the Omicron waves in ItalyResearch article Published on 2022-05-052022-10-05 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] antibody Blood breakthrough infections calculated COVID-19 COVID-19 mRNA Vaccination cumulative Delta Delta wave disease Disease modifying treatments dose enrolled finding Follow-up funding humoral immune response identify incidence Infection Italian Italy MONITOR mRNA vaccination multicenter cohort study Multiple multiple sclerosis omicron Patient preserved Probability protective role reduced reduction risk risk of infection SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection sclerosis second dose significantly therapy Vaccine vaccine dose vaccine doses [DOI] 10.1016/j.ebiom.2022.104042 [Article Type] Research article
In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infectionCOVID-19 혈청에 의해 유도된 체외 NET-osis는 백신 접종을 하지 않은 환자의 심각한 임상 경과 및 돌발성 감염의 면역 조절 장애와 관련이 있습니다.Article Published on 2022-05-042022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] ACE Activation affected age approach Breakthrough infection breakthrough infections CD14 CD16 CD3 CD4 CD4+ CD45 CD45RA CD45RO CD64 CD8 CD8+ Cell cells characterized circulating cytokine circulating cytokines classical Clinical course Clinical features complex Concentration controls COVID-19 COVID-19 infections COVID-19 patient COVID-19 patients COVID-19 sera COVID-19 treatment cytokine Cytokines Cytometry disease disease severity dysregulation effector cells expansion healthy healthy donors healthy subject healthy subjects highlight Hospital admission IFN-γ IL-17A IL-1β IL-6 immune Immune cell immune cells immune dysregulation immune response In-vitro inhibitor Inpatients Major marker memory B-cell Mild Mild disease moderate Monocytes myeloid naïve NET NETosis NETs neutrophil Neutrophil extracellular trap overexpressing Patient patients percentage Peripheral blood pilot study ramipril reduced reduction risk sera severe COVID-19 patient Sex T cell T cells T-cell T-cells Treatment viral clearance [DOI] 10.1038/s41598-022-11157-0 PMC 바로가기 [Article Type] Article