Increasing diagnostic possibilities using the geneLEAD VIII platform for detection of SARS-CoV-2SARS-CoV-2 검출을 위한 geneLEAD VIII 플랫폼을 사용한 진단 가능성 증가Article Published on 2021-12-012022-09-11 Journal: Journal of virological methods [Category] SARS, 치료기술, [키워드] absence addition blinded clinical sample clinical samples Complete Concordance coronavirus disease Coronavirus disease 2019 COVID-19 cycle threshold Diagnosis diagnostic diagnostic system diagnostic test E-gene geneLEAD. genomic sequence in vitro Increasing IVD Laboratory National Netherland Netherlands new virus PCR platform point-of-care positive Quality assurance Rapid Rapid diagnostic test reference standard reverse-transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2 testing STAT tested [DOI] 10.1016/j.jviromet.2021.114291 PMC 바로가기 [Article Type] Article
IFN-γ + cell response and IFN-γ release concordance after in vitro SARS-CoV-2 stimulation시험관 내 SARS-CoV-2 자극 후 IFN-γ + 세포 반응 및 IFN-γ 방출 일치Article Published on 2021-12-012022-09-11 Journal: European Journal of Clinical Investigation [Category] SARS, 치료법, [키워드] Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody case-control study CD4 T-cell CD8 CD8 T-cell Cell cellular Cellular immune response cellular response Concordance convalescent COVID-19 cross-sectional determine ELISA exposed healthcare workers. flow cytometry greater HCW HCWs healthcare healthcare worker Healthcare workers IFN-γ immune in vitro increased risk individual Infection less magnitude proportion protective immunity quantification SARS-CoV-2 SARS-CoV-2-infected patients Stimulation susceptibility Symptoms T cell T cells T-cell Response uninfected Viral protein Viral proteins [DOI] 10.1111/eci.13636 PMC 바로가기 [Article Type] Article
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: The CAPTURE study암 환자에서 예방 접종 후 SARS-COV-2 변이체에 대한 적응 면역 및 중화 항체 : 캡처 연구Clinical Trial Published on 2021-11-232022-08-13 Journal: Nature cancer [Category] MERS, SARS, 바이오마커, 변종, 임상, 진단, 치료기술, 치료제, [키워드] Adaptive immunity Administered administration anti-CD20 anti-CD20 treatment Antibody Response Antibody titers AZD1222 BNT162b2 Cancer cancer patient Cancer patients cancers capture CAPTURE study comparable Concordance COVID-19 COVID-19 immunity COVID-19 pandemic detectable dose evaluated Hematological malignancies Hematological malignancy implication individuals without cancer malignancies malignancy management median nAb response NAb responses NAbT Neutralising Antibodies neutralizing antibody Neutralizing antibody titer of BNT162b2 Patient patients Patients with cancer patients with haematological proportion prospective cohort study Prospective Study reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Seroconversion seroconversion rates solid cancer solid cancers T-cell Response T-cell responses undetectable vaccination Vaccine Vaccine-induced T-cell response Vaccine-induced T-cell responses Vaccines VOCs wildtype [DOI] 10.1038/s43018-021-00274-w PMC 바로가기 [Article Type] Clinical Trial
Whole-Genome Sequencing of SARS-CoV-2: Assessment of the Ion Torrent AmpliSeq Panel and Comparison with the Illumina MiSeq ARTIC ProtocolSARS-CoV-2의 전체 게놈 시퀀싱: Ion Torrent AmpliSeq 패널 평가 및 Illumina MiSeq ARTIC 프로토콜과의 비교Article Published on 2021-11-182022-09-11 Journal: Journal of Clinical Microbiology [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification AmpliSeq Analysis approach ARTIC assessment automated average Chef Complete Concordance consensus sequences coronavirus Coverage cultured isolate effective genetic mutation genetic mutations Genome identify Illumina Illumina Miseq Ion ion torrent less lowest Metrics MiSeq Next-generation sequencing pandemic Panel Patient produced Research SARS-CoV-2 sequence sequenced Sequencing severe acute respiratory syndrome Coronavirus single-nucleotide SNV specimen specimens tested the SARS-CoV-2 threshold variant viral genome Viral load viral loads whole-genome sequencing [DOI] 10.1128/JCM.00649-21 PMC 바로가기 [Article Type] Article
Nanopore metagenomic sequencing for detection and characterization of SARS-CoV-2 in clinical samples임상 샘플에서 SARS-COV-2의 검출 및 특성화를위한 나노 포어 메타 게놈 시퀀싱Research Article Published on 2021-11-182022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, 치료기술, 치료제, [키워드] Alpha Analysis assays characterization Classifier clinical sample clinical samples Complete concern Concordance COVID-19 pandemic Cycle threshold value diagnostic feasibility future work Gamma Genome less Lineage metagenomic sequencing Nanopore objective pathogen Pathogens PCR performed Phylogenetic Phylogenetic analysis positive Result RT-PCR SARS-CoV-2 sensitivity specificity specimen specimens Support variant variants Viral viral pathogens VoC was performed [DOI] 10.1371/journal.pone.0259712 PMC 바로가기 [Article Type] Research Article
A Highly Sensitive and Specific SARS-CoV-2 Spike- and Nucleoprotein-Based Fluorescent Multiplex Immunoassay (FMIA) to Measure IgG, IgA, and IgM Class AntibodiesResearch Article Published on 2021-11-172022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome analyses antibody antibody concentration assays Biosafety Level 3 BSL-3 calibrated calibration class collected comparability Concentration Concordance coronavirus coronavirus disease correlated strongly correlation COVID-19 enzyme fluorescent gold standard identify IgA IgG IgM Immunity immunoassay IMPROVE Infection International measure microneutralization Microneutralization test MNT moderate multiplex NAb titer NAb titers NAbs neutralization test Neutralizing antibodies neutralizing antibody neutralizing antibody titers nucleoprotein pandemic persistence population immunity quantification Receptor-binding domain SARS-CoV-2 SARS-CoV-2 antibody sensitive sensitivity Serological assay serological assays Specific specificity spike spike glycoprotein Standard Standardization Surveillance Symptom the WHO vaccination validation WHO WHO International Standard World Health Organization [DOI] 10.1128/Spectrum.01131-21 PMC 바로가기 [Article Type] Research Article
CRISPR-Cas12a-Based Detection for the Major SARS-CoV-2 Variants of Concern우려의 주요 SARS-CoV-2 변이체에 대한 CRISPR-Cas12a 기반 탐지Research Article Published on 2021-11-172022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alpha Amino acid amplification approach B.1.1.7 B.1.351 B.1.617.2 Beta clinical sample clinical samples Combination concern Concordance coronavirus COVID-19 pandemic CRISPR CRISPR-Cas system D614G delta variant Delta variants described detect detection Detection sensitivity E484K emerging SARS-CoV-2 variant evaluated Frame genotyping Immunity IMPROVE indicated Infection K417N L452R Laboratory Lambda limit of detection Lineage Major multiplex Mutation N501Y nucleic acid nucleic acid amplification nucleic acid amplification tests Open reading frame ORF8 PAM PCR primer protospacer adjacent motif public health Rapid test resource respiratory reverse transcription-PCR robust RT-PCR SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants Sequencing severe acute respiratory syndrome Coronavirus Spike protein T478K unmet need vaccination variant screening variants variants of concern variants of interest variants of SARS-CoV-2 virulent VOCs VOIs wild type [DOI] 10.1128/Spectrum.01017-21 PMC 바로가기 [Article Type] Research Article
Antibody Responses to SARS-CoV-2 Infection—Comparative Determination of Seroprevalence in Two High-Throughput Assays versus a Sensitive Spike Protein ELISAArticle Published on 2021-11-112022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Abbott Abbott IgG antibody assay analysed Analysis antibody Architect Asymptomatic can be used Characteristics collected comparable Concordance conducted contribute cut-off threshold demonstrated Determination determine discrepant result elevated ELISA ELISA kit evaluated Evidence false-negative feasible HCW HCWs healthcare worker individual longitudinal Mild NHS non-hospitalised nucleocapsid platform producing provided response responses ROC Curve Roche Roche Elecsys SARS-CoV-2 antibody assay SARS-CoV-2 SARS-CoV-2 IgG sensitive sensitivity Serological testing serology serology analysis Seroprevalence Site spike TBS The Binding Site total antibody assay threshold were used [DOI] 10.3390/vaccines9111310 PMC 바로가기 [Article Type] Article
Comparing the Attitude toward the COVID-19 and the 2020/21 and 2019/20 Flu Vaccination Campaigns among Italian Healthcare WorkersArticle Published on 2021-11-112022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] allergies allergy analyzed Attitude characterized chronic disease Chronic diseases Concordance condition correlation COVID-19 COVID-19 vaccination COVID-19 vaccine Evidence Factor flu flu vaccination greater HCW HCWs health care workers health condition healthcare worker Hypothesis Italian medication medications men no difference Prevalence proportion Quantitative questionnaire Questionnaires reported tested vaccination Vaccine Vaccine hesitancy while women worker [DOI] 10.3390/vaccines9111312 PMC 바로가기 [Article Type] Article
In Silico Identification and Clinical Validation of a Novel Long Non-Coding RNA/mRNA/miRNA Molecular Network for Potential Biomarkers for Discriminating SARS CoV-2 Infection SeveritySARS CoV-2 감염 중증도를 판별하기 위한 잠재적 바이오마커에 대한 새로운 Long Non-Coding RNA/mRNA/miRNA 분자 네트워크의 실리코 식별 및 임상 검증Article Published on 2021-11-092022-09-11 Journal: Cells [Category] MERS, SARS, 바이오마커, 진단, [키워드] Analysis assays bioinformatics Biomarker Biomarkers circulating RNAs clinical clinically coding and non-coding RNAs Concordance controls coronavirus COVID-19 COVID-19 infection potential biomarker COVID-19 severity CRP Cytokines database determine develop diagnostic Diagnostic markers differential expression Diseases downregulation early infection Extensive ferritin Genetic Health health problem healthy controls healthy volunteers identification IL11RA IL11RA protein overexpression in silico in-silico infected patients Infection infection control interleukins genetic network LDH Long marker Mild molecular mRNA network Non-invasive novel pandemic Potential Potential biomarker potential biomarkers Predictive procalcitonin Protein Quantitative Quantitative RT-PCR response retrieved RNA RT-PCR SARS CoV-2 infection SARS-COV-2 infection severity prediction severe cases severe pneumonia severity significantly subject Symptoms the healthy upregulated Vaccine validation Validity variety [DOI] 10.3390/cells10113098 PMC 바로가기 [Article Type] Article