A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase뉴클레오사이드 유사체와 SARS-CoV-2 RNA 의존성 RNA 중합효소의 상호작용에 대한 고찰Review Published on 2021-06-302022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 치료제, [키워드] Antiviral antiviral drugs approved clinical development computational analysis CoV COVID-19 CoVs drug Efficacy ExoN ExoN proofreading Favipiravir human CoV human CoVs Infection information inhibitor Interaction lack nucleoside nucleoside analogue Nucleoside analogues outbreak platform preserved RdRP Remdesivir Repurposed drug ribavirin RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 sofosbuvir tenofovir Vaccine [DOI] 10.1016/j.ijbiomac.2021.03.112 PMC 바로가기 [Article Type] Review
Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species인간과 다른 종의 ACE2에 대한 박쥐 코로나바이러스 RaTG13 바이러스의 결합 및 분자적 기초Article Published on 2021-06-242022-09-11 Journal: Cell [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 orthologs acute respiratory syndrome acute respiratory syndrome coronavirus animal reservoirs binding carried complex continuous surveillance coronavirus COVID-19 CoVs cross-neutralize cross-reactive antibody evaluated global pandemic hACE2 horseshoe bat Host host range Human human ACE2 induce intermediate horseshoe bat intermediate horseshoe bat. mAb mechanism molecular basis monoclonal antibody phylogenetically Prevent pseudovirus RaTG13 RBD Receptor binding Receptor binding domain reservoir residue residues respiratory SARS-CoV-2 SARS-CoV-2 RBD severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Surveillance the SARS-CoV-2 variants variants of concern virus VOCs [DOI] 10.1016/j.cell.2021.05.031 PMC 바로가기 [Article Type] Article
In Vitro Models for Studying Entry, Tissue Tropism, and Therapeutic Approaches of Highly Pathogenic CoronavirusesReview Article Published on 2021-06-212022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] binding cell entry cell line cell receptor cellular protease CoV CoVs ENCODE family Coronaviridae Genome host cell in vitro model information inhibiting knowledge membranes methodology Model offer Pathogenesis positive-sense Protein RNA virus RNA viruses structural proteins the S protein the Spike therapeutic approaches therapeutic intervention tropism viral tropism [DOI] 10.1155/2021/8856018 PMC 바로가기 [Article Type] Review Article
In Vitro Models for Studying Entry, Tissue Tropism, and Therapeutic Approaches of Highly Pathogenic CoronavirusesReview Article Published on 2021-06-212022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] binding cell entry cell line cell receptor cellular protease CoV CoVs ENCODE family Coronaviridae Genome host cell in vitro model information inhibiting knowledge membranes methodology Model offer Pathogenesis positive-sense Protein RNA virus RNA viruses structural proteins the S protein the Spike therapeutic approaches therapeutic intervention tropism viral tropism [DOI] 10.1155/2021/8856018 PMC 바로가기 [Article Type] Review Article
Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variantsResearch Article Published on 2021-06-182022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] approach B.1.1.7 B.1.351 binding caused characterized circulating Combined CoVs Critical develop effective vaccine effort fusion inhibitor fusion protein global public health HCoV-229E HCoV-NL63 human CoVs impacted in viral Infection information inhibiting inhibitor inhibitory activity lipopeptide mechanism membrane fusion MERS-CoV Mutation pandemic of COVID-19 peptide peptides SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants second sequence South Africa Spike protein stability strain structural property Treatment United Kingdom variant [DOI] 10.1080/22221751.2021.1937329 PMC 바로가기 [Article Type] Research Article
The landscape of antibody binding in SARS-CoV-2 infectionSARS-COV-2 감염에서 항체 결합의 풍경Research Article Published on 2021-06-182022-08-13 Journal: PLoS Biology [Category] Biochemistry, MERS, SARS, 진단, 치료법, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody binding B cell epitope B cell epitopes binding convalescent coronavirus correlated CoV proteins COVID-19 CoVs cross-reactivity develop diagnostic Diagnostic accuracy diagnostics ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope Epitopes homologous human CoVs human sera humoral immunogen humoral immunogens identify illness Illness severity induce membrane naïve nucleocapsid occurred ORF3a ORF8 protein ORF8 proteins other coronavirus other coronaviruses pandemic peptide peptide sequences Profiling Protein Proteins proteome reactive reactivity respiratory robust antibody response robust antibody responses SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes SARS-COV-2 infection SARS-CoV-2 proteome sequence severity the SARS-CoV-2 Therapeutics ultradense peptide microarray Vaccines [DOI] 10.1371/journal.pbio.3001265 PMC 바로가기 [Article Type] Research Article
A Comparative Analysis of Coronavirus Nucleocapsid (N) Proteins Reveals the SADS-CoV N Protein Antagonizes IFN-β Production by Inducing Ubiquitination of RIG-IImmunology Published on 2021-06-162022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute diarrhea acute respiratory syndrome Analysis binding activity caused claimed Comparative conducted coronavirus CoV CoV infection COVID-19 pandemic CoVs Degradation Delay epidemic diarrhea Host IBV IFN IFN response IFN-β independent Inducing infected cell Infectious Bronchitis Virus inhibiting Interaction interferon MERS-CoV Middle East nucleocapsid nucleocapsid protein offer Porcine deltacoronavirus Production Protein retinoic acid-inducible gene I (RIG-I) RIG-I RNA SARS-CoV SARS-CoV-2 Severity of disease subsequent suppress swine acute diarrhea syndrome coronavirus (SADS-CoV) syndrome the N protein therapy ubiquitination Viral protein viruses [DOI] 10.3389/fimmu.2021.688758 PMC 바로가기 [Article Type] Immunology
Intra-species sialic acid polymorphism in humans: a common niche for influenza and coronavirus pandemics?Review Article Published on 2021-06-142022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, 신종인플루엔자, [키워드] 1918 H1N1 pandemic acute respiratory syndrome Asymptomatic co-evolution confirmed case coronavirus CoV COVID-19 pandemic CoVs death Epidemic Epidemics Evolution Fatality rate General population H1N1 influenza H1N1 pandemic Host impacted infected individual Influenza Influenza and coronavirus Influenza virus mild illness mild symptoms pandemic Pandemics polymorphism receptor recognize severe cases sialic acid sialic acid receptor the United State Variation virus [DOI] 10.1080/22221751.2021.1935329 PMC 바로가기 [Article Type] Review Article
Phycobilins as Potent Food Bioactive Broad-Spectrum Inhibitors Against Proteases of SARS-CoV-2 and Other Coronaviruses: A Preliminary StudyMicrobiology Published on 2021-06-102022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Against Antiviral Antiviral compound approach approaches binding affinity broad-spectrum inhibitors coronavirus Coronaviruses CoV COVID-19 COVID-19 pandemic CoVs disease effective enzyme Evolution food food bioactive constituents in silico in vitro inhibitor M pro main protease MERS MPro mutant mutant strain Other pandemic coronavirus Papain-like protease Phycobilin PLPro potent protease Proteases reduce Research SARS-CoV-2 therapeutic drug trials United Kingdom Vaccine [DOI] 10.3389/fmicb.2021.645713 PMC 바로가기 [Article Type] Microbiology
SARS-CoV-2: An Overview of Virus Genetics, Transmission, and ImmunopathogenesisReview Published on 2021-06-102022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] addition Analysis approach bat caused cellular receptors coronavirus country CoV COVID-19 CoVs cross Cross-species transmission demonstrated Disease progression Evolution genetics Genome Host hosts human coronavirus Immune cell immune response Intervention likelihood new virus outbreak pandemic pathogenicity persistence Point mutation Recombination reduce reported reservoir RNA viruses SARS-CoV SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection similarity spike gene Spike protein Spread the SARS-CoV-2 virus virus isolate virus transmission Wuhan, China [DOI] 10.3390/ijerph18126312 PMC 바로가기 [Article Type] Review