A review of clinical efficacy data supporting emergency use authorization for COVID-19 therapeutics and lessons for future pandemicsArticle Published on 2022-10-012022-11-15 Journal: Clinical and translational science [Category] COVID19(2023년), SARS, 치료제, [키워드] Anti-inflammatory Antiviral approved authorization chloroquine/hydroxychloroquine Clinical data Clinical efficacy clinical evidence clinical study clinical trial coronavirus disease COVID-19 COVID-19 pandemic COVID-19 therapeutics Critical demonstrated drug Efficacy Emergency Emergency use authorization EUA Evidence FDA food Guidance majority medication Pandemics public health emergency question Randomized controlled trial RCT Regulatory Resilience statistically significant submitted subsequent Support supported therapeutic withdrawn [DOI] 10.1111/cts.13384 PMC 바로가기
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicryArticle Published on 2022-10-012022-11-16 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Affect antiviral response attenuate caused chromatin Control coronavirus coronavirus disease COVID-19 Critical Deletion demonstrated disrupt Epigenetic function global pandemic Host host cell host cell response Infection mechanism mimicking molecular basis motif ORF8 ORF8 gene post-translational modification promote Protein provide recent Region Regulation required SARS-CoV-2 severity of COVID-19 suppress the SARS-CoV-2 transcriptional regulation transcriptional response viral genome Viral protein [DOI] 10.1038/s41586-022-05282-z PMC 바로가기
External quality assessment of SARS-CoV-2 serology in European expert laboratories, April 2021Article Published on 2022-10-012022-11-15 Journal: Eurosurveillance [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies characterisation collected composed country COVID-19 Critical detect Diagnosis diagnostics eight epidemiological EQA Europe European evaluate External human SARS-CoV-2 human serum immune response Immunoglobulin indicated involved Laboratory mitigate natural infection neutralising antibody participant performed provided public health measures robust SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody responses SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 transmission Sensitivity and specificity serological serological test serology Support the vaccine Vaccine [DOI] 10.2807/1560-7917.ES.2022.27.42.2101057 PMC 바로가기
Catching BETs by virusesArticle Published on 2022-10-012022-11-16 Journal: Biochimica et biophysica acta. Gene regulatory mechanisms [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acetylated acetylation being BET BRD4 bromodomain cellular chromatin component Critical docking domain envelope protein ET domain evade function Genome highlight Histones Host host cell innate immune response Interaction maintain mechanism Protein SARS-CoV-2 target transcriptional regulators viral infection Viral protein Viral proteins virus viruses [DOI] 10.1016/j.bbagrm.2022.194859 PMC 바로가기
Negative predictive value of procalcitonin to rule out bacterial respiratory co-infection in critical covid-19 patientsResearch article Published on 2022-10-012022-10-05 Journal: The Journal of Infection [Category] 바이오마커, 진단, [키워드] added Admission antibiotic Antibiotics association AUC Bacterial bacterial co-infection Biomarker C-reactive protein clinician Co-infection country COVID-19 COVID-19 pneumonia Critical CRP cut-off determine Diagnosis diagnostic evaluate evaluated fungal infections ICU ICU admission Logistic regression Mortality negative Negative predictive value outcome outcomes pandemic Patient patients with COVID-19 PCT Pneumonia predict Predictive procalcitonin Result retrospective cohort study secondary was performed worsening [DOI] 10.1016/j.jinf.2022.06.024 [Article Type] Research article
ASSOCIATION OF TNF-α, TGF-β1, AMPHIREGULIN, IL-2, AND EGFR WITH PULMONARY FIBROSIS IN COVID-19Short communication Published on 2022-10-012022-10-05 Journal: Journal of infection and public health [Category] 바이오마커, [키워드] age analyzed association blood sample chest CT scan coronavirus disease COVID-19 COVID-19 pneumonia patient Critical cytokine discharged EGFR ELISA evaluate evaluated fibrosis hospital IL-2 mechanism men Patient Pneumonia pulmonary pulmonary fibrosis Serum level severity TGF TGF-β1 the patient TNF- α TNF-α was performed women [DOI] 10.1016/j.jiph.2022.08.007 [Article Type] Short communication
HIV suppression was maintained during the COVID-19 pandemic in Malawi: a program-level cohort studyResearch article Published on 2022-10-012022-10-05 Journal: Journal of clinical epidemiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI adjusted adjusted odds ratio age Antiretroviral therapy ART Care clinics cohort study collected COVID-19 COVID-19 epidemic COVID-19 pandemic Critical declined Evidence examined Government HIV introduced logistic regression models Malawi measure multiple imputation National NNRTI no difference objective outcome pandemic Patient patients population-based cohort predictor protease reduce reduced regimen regimens Result routine SARS-CoV-2 Sex Spread stratified Support Suppression of HIV replication transcriptase transfer Treatment Treatment outcome treatment regimen Viral load VL testing with HIV [DOI] 10.1016/j.jclinepi.2022.06.019 [Article Type] Research article
Mass Switch From Intravenous to Subcutaneous Tocilizumab in Rheumatic Diseases During the SARS-COV-2 PandemicArticle Published on 2022-10-012022-11-15 Journal: Journal of clinical rheumatology : practical reports on rheumatic & [Category] COVID19(2023년), SARS, 진단, [키워드] administration adverse event Analysis Cell COVID Critical disease effective Follow-up Giant giant cell arteritis headache hospital injection intravenous juvenile idiopathic arthritis mass pandemic Patient remained rheumatoid arthritis rheumatological patient rheumatology Safe Subcutaneous subgroup analysis switch switching Systemic sclerosis TCZ the SARS-CoV-2 Tocilizumab Treatment was performed [DOI] 10.1097/RHU.0000000000001862 PMC 바로가기
Ginkgo biloba in the management of the COVID-19 severityArticle Published on 2022-10-012022-11-15 Journal: Archiv der Pharmazie [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute lung injury acute respiratory distress acute respiratory syndrome aggregation alleviate Anti-inflammatory antioxidant Antiviral Antiviral effect attenuate booster complementary complementary medicine complications coronavirus disease Coronavirus-2 COVID-19 COVID-19 severity Critical drug Effect Effectiveness extreme Ginkgo Ginkgo biloba impede Infection inflammatory disorder management mechanisms nanomedicines Neutrophil elastase offer oxidative stress Platelet proinflammatory cytokines protease Proteases provide SARS-CoV-2 symptomatic syndrome therapy thrombosis viral proteases [DOI] 10.1002/ardp.202200188 PMC 바로가기
Risk of reinfection and disease after SARS-CoV-2 primary infection: Meta-analysisArticle Published on 2022-10-012022-11-16 Journal: European Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 변종, [키워드] baseline cohort study COVID-19 criteria Critical disease evaluate evaluated Frequency Gender health care need individuals Infection lethal disease Meta-analysis natural immunity no substantial difference not affected omicron Omicron variant performed pooled rate Primary infection proportion reached Reinfection remained Repository risk SARS-CoV-2 searched severity stratified subject subjects subset vaccination vaccine dose viral strain were recorded [DOI] 10.1111/eci.13845 PMC 바로가기