Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients전체 전사체 RNA 시퀀싱은 COVID-19 환자의 말초 혈액에서 유의미하게 차별적으로 발현된 mRNA, miRNA, lncRNA 및 관련 조절 생물학적 경로를 나타냅니다Research Article Published on 2021-04-012022-09-10 Journal: Mediators of Inflammation [Category] MERS, SARS, 유전자 메커니즘, [키워드] “cytokine storm” acute respiratory syndrome acute respiratory syndrome coronavirus AKT1 Analysis Antigen antigen processing Biological biosynthetic characterized China coding collected competing control group controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples CXCL8 cytokine cytokine production Cytokine storm cytotoxicity diagnostic biomarker Diagnostic biomarkers differentially expressed downregulated enrichment analysis excessive cytokine production FCGR2A Functional enrichment analyses Gene ontology glycogen ground-glass opacity healthy controls healthy donor healthy donors highlight hub genes indicated Inflammation Interaction involved leukocyte leukocytes lncRNA long noncoding RNA lung tissues lymphocyte Lymphocytes mechanism Messenger RNA messenger RNAs microRNA MicroRNAs Migration miRNA miRNAs mRNA mRNAs noncoding RNA Noncoding RNAs pandemic Pathogenesis peripheral Peripheral blood positive potential mechanism potential mechanisms PPI presenting protein-protein interaction Regulating Regulation Regulatory respiratory resulting RNA SARS-CoV-2 selected Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathway Significant significantly STAT3 systemic inflammation T cell T cell activation target the healthy therapeutic tissue TLR2 TNFRSF1B upregulated [DOI] 10.1155/2021/6635925 PMC 바로가기 [Article Type] Research Article
Growth Arrest-Specific Factor 6 (GAS6) Is Increased in COVID-19 Patients and Predicts Clinical OutcomeCommunication Published on 2021-03-262022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] Admission airway alveolar cell analyzed AXL clinical clinical trial COVID-19 COVID-19 patient COVID-19 severity cytokine production Deceased disease emergency ward evaluated exhibited expressed Factor GAS6 groups highest human macrophage immune response immunothrombosis Increased induce initial LPS macrophage differentiation macrophages marker MERTK mRNA outcome Patient patients plasma concentration pro-inflammatory responses Prognosis quartile receptor reduced Respiratory system SARS-CoV-2 SARS-CoV-2-positive patients severity significant difference survival TAM the disease THP-1 viral infection vitamin K [DOI] 10.3390/biomedicines9040335 PMC 바로가기 [Article Type] Communication
Diseasome and comorbidities complexities of SARS-CoV-2 infection with common malignant diseases일반적인 악성 질환과 SARS-CoV-2 감염의 질병 및 동반 질환 복잡성Article Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] ACTB APCDD1 approach bioinformatics Bioinformatics analysis Cancer cancer patient Cancer patients cancers CASP1 cell activation chemokine CHI3L1 CLEC1B COL6A3 Colon Comorbidities Comorbidity conditions COVID-19 CXCL10 CXCL8 cytokine cytokine production dataset DDIT4 deregulated develop disease diseasome dysregulated FABP5 FN1 GAPDH Gene Expression Omnibus Genes GPNMB higher risk HMOX1 identify IGFBP3 immune systems JUND kidney LGALS1 Lungs malignant disease malignant tumors Marco molecular Mortality MSH3 MYO10 NPC2 OAS2 Ontology outcome pathway Pathways PRDX3 ribosome biogenesis S100A8 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections semantic similarity severity signaling pathway synergistic SYTL2 the disease Thyroid Timp1 transcriptomic transcriptomic data tumors VCAN Wnt signaling pathway [DOI] 10.1093/bib/bbab003 PMC 바로가기 [Article Type] Article
Umbilical cord blood-derived microglia-like cells to model COVID-19 exposureArticle Published on 2021-03-192022-10-29 Journal: Translational Psychiatry [Category] COVID-19, [키워드] approach Biomarker Brain brain development can be used Cell childhood children COVID-19 COVID-19 pandemic Critical cytokine cytokine production developmental fetal generate immune immune activation immune cells impacted in vivo inaccessible Inflammatory methodology microglia microglial Molecular neuroscience mononuclear cell mononuclear cells morbidity morphologically Neonatal Neonate Non-invasive Peripheral blood priming programming SARS-COV-2 infection severe cases stem cells Umbilical cord umbilical cord blood unique [DOI] 10.1038/s41398-021-01287-w PMC 바로가기 [Article Type] Article
The Characterization of Disease Severity Associated IgG Subclasses Response in COVID-19 PatientsCOVID-19 환자의 질병 중증도 관련 IgG 하위 분류 반응의 특성화Immunology Published on 2021-03-042022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, [키워드] age analyzed antibodies Antibody Response Antigen Asymptomatic COVID-19 characterization chemokines Clinical outcome Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient cytokine cytokine production Cytokines disease disease severity dysregulated immune response dysregulated immune responses Evidence had no hospitalized patient Host immune response Ig isotype Ig isotypes IgG IgG subclasse IgG subclasses IgG1 IgG3 IL-1β immune responses Immunoglobulin Increasing isotypes Mild moderate Multiple multiple cytokines NAb activity Nasopharyngeal swab negative correlation neutralizing antibody no effect nucleocapsid protein Patient positively correlated Protein RBD Receptor binding domain response SARS-CoV-2 serum severe cases severity Sex significantly T cell T cell response T cell responses Viral Viral load was related [DOI] 10.3389/fimmu.2021.632814 PMC 바로가기 [Article Type] Immunology
Specialized Pro-Resolving Mediators as Potential Regulators of Inflammatory Macrophage Responses in COVID-19COVID-19에서 염증성 대식세포 반응의 잠재적 조절자로서의 전문화된 해결 중재자Review Published on 2021-02-242022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] acting consequence COVID-19 COVID-19 pathogenesis cytokine production Cytokine storm event function Health homeostatic Inflammation lipid mediator lipid mediators/specialized pro-resolving mediators (SPMs) Macrophage macrophage activation syndrome (MAS) Macrophage infiltration macrophage phenotype management mediator molecular outbreak Pandemics Potential promote regulate regulator resolution of inflammation response SARS-CoV2 severe acute respiratory syndrome corona virus (SARS-CoV2) severity therapeutic potential Treatment with COVID-19 [DOI] 10.3389/fimmu.2021.632238 PMC 바로가기 [Article Type] Review
Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19Immunology Published on 2021-02-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Care caused Clinical features Coagulopathy condition consumptive coronavirus coronavirus disease COVID-19 COVID-19 patient cytokine production Cytokine storm death dysregulated Fever health systems host response Hypovolemia Immunopathogenesis Immunosuppression Infection killing Leukocytosis leukopenia life-threatening management managing manifestation multi-organ dysfunction opportunistic Infections pathophysiological pathophysiology Perspective Pneumonia predisposition Respiratory failure SARS-CoV-2 Sepsis Septic shock syndrome systemic illness Vascular [DOI] 10.3389/fimmu.2021.602848 PMC 바로가기 [Article Type] Immunology
COVID-19 Infection and Previous BCG Vaccination Coverage in the Ecuadorian PopulationArticle Published on 2021-01-272022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] affected Amino acid sequences association Bacillus BCG BCG vaccination bcg vaccine BCG vaccine coverage change conducted Coverage COVID-19 COVID-19 cases cytokine production develop Ecuador Epidemic homologous identify IMPROVE information mathematical Ministry of Health National organization Pan pandemic Pathogens performed Population Prevalence prevalence of COVID-19 QGIS SARS-CoV-2 statistical These data vaccination Vaccine variations with COVID-19 younger people [DOI] 10.3390/vaccines9020091 PMC 바로가기 [Article Type] Article
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets붉은털원숭이, 개코원숭이 및 마모셋 폐의 SARS-CoV-2 급성 감염에 대한 반응Article Published on 2021-01-012022-09-12 Journal: Nature Microbiology [Category] MERS, SARS, 진단, [키워드] acute infection acute respiratory syndrome adaptive age antibody Baboon Bronchoalveolar lavage bystander Cellular immune response Clinical sign clinical trials Computed tomography coronavirus coronavirus disease COVID-19 cytokine production cytokine response distress group humans Immune cell immunohistochemical analyses Infection interferon response lung Lung inflammation Lungs macaque macaques memory Mild moderate Non-human Pathologies progression response rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific IgG T-cell Therapies titre Vaccine viral infection Viral RNA shedding was increased [DOI] 10.1038/s41564-020-00841-4 PMC 바로가기 [Article Type] Article
Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19과염증 COVID-19에서 백혈구에 의한 순환 사이토카인과 자발적 사이토카인 생산 간의 불일치Clinical Trial Published on 2021-01-012022-09-12 Journal: Journal of leukocyte biology [Category] MERS, 임상, 진단, [키워드] activated Activation analyzed blockade cellular circulating cytokine circulating leukocyte contribute Control controls COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine production Cytokine storm cytokine storm, monocytes. Cytokines disease example flow cytometry healthy control healthy controls hyperinflammation Hyperinflammatory IL-1β IL-6 IL-8 immunoassay investigated leukocyte LPS lymphocyte mismatch monocyte Monocytes Patient patients with COVID-19 PBMC produced recruited Sepsis sepsis patient sepsis patients severe COVID-19 Support surface marker TNF Treatment university was used were measured worldwide pandemic [DOI] 10.1002/JLB.5COVBCR0720-310RR PMC 바로가기 [Article Type] Clinical Trial