Rationale of using the dual chemokine receptor CCR2/CCR5 inhibitor cenicriviroc for the treatment of COVID-19COVID-19 치료에 이중 케모카인 수용체 CCR2/CCR5 억제제 세니크리비록을 사용하는 이유Review Published on 2022-06-242022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome coronavirus addition agent anti-inflammatory action anti-inflammatory actions attenuate caused CCR2 CCR5 Cenicriviroc Chemokine receptor clinical Clinical course clinical trial clinical trials Combination complications coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Dexamethasone fibrosis global pandemic IMPROVE infecting Inflammation inhibitor investigational agent late stage NASH nonalcoholic steatohepatitis Organ failure outcome outcomes pathway Pathways patients with COVID-19 patients with HIV Prevent rationale reduce respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease Standard of care steatohepatitis the disease Treatment Trial [DOI] 10.1371/journal.ppat.1010547 PMC 바로가기 [Article Type] Review
Efficacy and safety of systemic, high-dose glucocorticoid therapy for idiopathic sudden sensorineural hearing loss Study protocol for a three-armed, randomized, triple-blind, multicenter trial (HODOKORT)article Published on 2022-06-202024-09-02 Journal: HNO [Category] 대상포진, [키워드] Corticosteroids Dexamethasone Glucocorticoids humans idiopathic Prednisolone Randomized controlled trial Steroids Sudden hearing loss [DOI] 10.1007/s00106-022-01184-8 PMC 바로가기 [Article Type] article
Two Case Reports of Life-Threatening Croup Caused by the SARS-CoV-2 Omicron BA.2 Variant in Pediatric Patients소아 환자에서 SARS-CoV-2 Omicron BA.2 변이체로 인한 생명을 위협하는 크룹에 대한 2건의 사례 보고Case Reports Published on 2022-06-202022-09-11 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, [키워드] Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway barking cough Cardiopulmonary Cardiopulmonary resuscitation Cardiopulmonary Resuscitation (CPR) caused causes Chain Reaction characterized Chest children complications coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) cough COVID-19 Croup Dexamethasone discharged emergency department Endotracheal intubation epinephrine healthy hoarseness IMPROVE indicated Infant Infection intensive care intubation knowledge life-threatening mechanical ventilation nasopharyngeal sample Nasopharyngeal samples nebulized omicron Omicron variant Pathogens Patient pediatric polymerase chain polymerase chain reaction produced receiving report reported required Respiratory failure respiratory viral Resuscitation reverse transcription polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Severe Croup. stridor the SARS-CoV-2 Transcription treated Treatment underlying diseases upper airway variant viral infection [DOI] 10.3346/jkms.2022.37.e192 PMC 바로가기 [Article Type] Case Reports
Glucocorticoids Bind to SARS-CoV-2 S1 at Multiple Sites Causing Cooperative Inhibition of SARS-CoV-2 S1 Interaction With ACE2글루코코르티코이드는 여러 부위에서 SARS-CoV-2 S1에 결합하여 ACE2와 SARS-CoV-2 S1 상호작용을 협력적으로 억제합니다Article Published on 2022-06-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 (angiotensin converting enzyme 2) Affect Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-SARS-CoV-2 Asymptomatic Beta bind binding binding energy binding pocket binding pockets biochemical biochemically catalytic activity causing cellular receptor chimeric conformational state contributed Cooperative coronavirus cortisol COVID COVID-19 patients Delta Dexamethasone disrupt E484K enzyme Glucocorticoids indicated inhibition Innate immunity Interaction K417N Limited mass spectrometry mechanism Mild molecular molecular dynamics monoclonal antibody Multiple mutant mutated N501Y omicron Omicron variants Protein Receptor binding domain reduce mortality SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2 spike Site variant without affecting [DOI] 10.3389/fimmu.2022.906687 PMC 바로가기 [Article Type] Article
Early dexamethasone use as a protective measure in non-mechanically ventilated critically ill patients with COVID-19: a multicenter, cohort study Research Published on 2022-06-132022-10-05 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] 1:1 24 hour benefit cohort study consequence COVID-19 COVID19 Critically ill patient debatable Dexamethasone higher odd hospital ICU admission ICUs in-hospital mortality initiated intensive care unit LOS mechanical ventilation Mortality multicenter multicenter cohort study outcome Patient patients with COVID-19 Prevent primary endpoint Propensity score Protective required Respiratory failure SOFA score statistically significant the timing Tocilizumab two group Ventilated ventilated patients was used with COVID-19 [DOI] 10.1038/s41598-022-13239-5 [Article Type] Research
A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort studyResearch article Published on 2022-06-092022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, 임상, [키워드] accelerate Accuracy agency APACHE II assessment Berlin Biomarker Biomarkers Charité clinical clinical disease progression Clinical outcome clinical risk clinical trials Cohort conducted Council COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 severity death Dexamethasone disease prognosis disease severity education ERC European finding foundation funding Germany hallmark Healthcare system healthy individuals help hospitalised introduced LC-MS/MS LLOQ machine learning median Medicine Mild Mobility moderate multiplex node observational study outcome Patient patient cohort patients with COVID-19 peptide peptides predicted Prognosis Prognostic value Protein proteomics quantification Registered registry Research resource SARS-CoV2 Science sensitivity severe COVID-19 severity Severity stratification SOFA Spectrometry Standard of care stratified Support supported survival System targeted proteomics the median the WHO Therapies Treatment Wellcome Trust [DOI] 10.1016/j.eclinm.2022.101495 [Article Type] Research article
Response to Glucocorticoid Therapy in Patients with Mild to Moderate Coronavirus Disease 2019 at a Japanese Care FacilityArticle Published on 2022-06-042023-07-08 Journal: The Tohoku Journal of Experimental Medicine [Category] COVID19(2023년), [키워드] Coronavirus disease 2019 Dexamethasone Glucocorticoids Outpatient Prednisolone [DOI] 10.1620/tjem.2022.J022
Baricitinib in hospitalised patients with COVID-19: A meta-analysis of randomised controlled trialsResearch article Published on 2022-06-032022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] 28-day mortality 95% CI Analysis Anti-inflammatory Anti-viral Baricitinib COVID COVID19 database death Dexamethasone discharge disease duration of hospitalisation ECMO Efficacy finding funding hospitalised patient improved mortality IMV inhibitor Invasive mechanical ventilation Jak Janus kinase Janus kinase inhibitors Meta-analysis outcome patients patients with COVID-19 performed positive pressure ventilation progression PROSPERO database random-effects model randomised controlled trial RCT reduce mortality reduced Registered Respiratory failure searched severe disease shown Standard of care Standard therapy statistically significant statistically significant reduction Tocilizumab Treatment with COVID-19 [DOI] 10.1016/j.eclinm.2022.101489 [Article Type] Research article
Association between dexamethasone treatment and the host response in COVID-19 patients admitted to the general ward일반병동에 입원한 코로나19 환자의 덱사메타손 치료와 숙주반응의 연관성Article Published on 2022-06-032022-09-11 Journal: Respiratory Research [Category] 바이오마커, [키워드] Activation Admission Biomarker Cell Clinical outcome clinical outcomes Coagulation comparable COVID-19 COVID-19 patient Dexamethasone Endothelial cell host response IL-1 IL-1 receptor antagonist implementation IMPROVE Inflammation investigated mechanism mechanism of action Modification not affected oxygen parameter Patient plasma receptor antagonist response Standard of care supplementary oxygen These data Treatment [DOI] 10.1186/s12931-022-02060-3 PMC 바로가기 [Article Type] Article
Comparing efficacy and safety of tocilizumab and methylprednisolone in the treatment of patients with severe COVID-19중증 COVID-19 환자 치료에서 토실리주맙과 메틸프레드니솔론의 효능 및 안전성 비교Article Published on 2022-06-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] 28-day mortality 95% CI adverse event adverse events alternative caused clinical clinical response comparable COVID Cox regression analysis CRP Dexamethasone dose doses duration of hospitalization Efficacy and safety faster group groups hospitalized patient hospitalized patients ICU admission improvement intravenous methylprednisolone Methylprednisolone not significantly different occurred Other outcome oxygen oxygen saturation Patient Primary outcome problem prospective cohort study secondary Secondary outcomes severe COVID-19 Sleep disturbance Sleep disturbances statistically significant Tocilizumab Treatment were recorded [DOI] 10.1016/j.intimp.2022.108689 PMC 바로가기 [Article Type] Article