eight – Page 10 – Communicable Diseases Research

Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trial

Clinical Trial

Published on 2022-08-012022-10-05
Journal: The Lancet. Haematology [Category] COVID19(2023년), SARS, 임상, 치료제,

Computational repurposing approach for targeting the critical spike mutations in B.1.617.2 (delta), AY.1 (delta plus) and C.37 (lambda) SARS-CoV-2 variants using exhaustive structure-based virtual screening, molecular dynamic simulations and MM-PBSA methods

철저한 구조 기반 가상 스크리닝, 분자 역학 시뮬레이션을 사용하여 B.1.617.2(델타), AY.1(델타 플러스) 및 C.37(람다) SARS-CoV-2 변이체에서 중요한 스파이크 돌연변이를 타겟팅하기 위한 전산 용도 변경 접근 방식 및 MM-PBSA 방법

Article

Published on 2022-08-012022-09-11
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신약개발,

[키워드] ACE-2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin-converting enzyme 2 approach Area atovaquone AY.1 B.1.617.2 binding affinity binding site candidate causative agent complex complexes Compound contagious contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical Delta delta variant Delta variants docking result docking results drug Drug repurposing drug-likeness drugs eight enzyme FDA approved drug FDA approved Drugs followed by genomic help heparin highest binding affinity Host hydrogen Hydrogen bond identify in silico inhibiting inhibitor inhibitors interact Interaction interactions Lambda Ligand MD simulation MD simulations molecular molecular docking molecular dynamics Molecular dynamics simulation Molecular mechanics morbidity and mortality mortality rates Mutation mutations Praziquantel Protein Proteins RBD Receptor-binding domain reported Research researcher residue SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simulation spike spike mutation Spike protein stability surface surface area targets the receptor-binding domain the spike protein variant variants variants of concern viral cell Virtual screening VoC was done was performed wild type Wuhan Wuhan, China
[DOI] 10.1016/j.compbiomed.2022.105709 PMC 바로가기 [Article Type] Article

Childhood COVID-19 vaccine acceptance and preference from caregivers and healthcare workers in China: A survey experiment

Randomized Controlled Trial

Published on 2022-08-012022-10-04
Journal: Preventive medicine [Category] 임상,

[키워드] acceptance Adverse reaction age approval assigned attribute attributes Child childhood children China conducted Coverage COVID-19 COVID-19 vaccination COVID-19 vaccine Effect Efficacy eight experiment HCW HCWs Health care worker healthcare worker Immunity independent information Odds ratio parental Randomly receive respondent risk survey Survey experiment. vaccination Vaccine
[DOI] 10.1016/j.ypmed.2022.107138 PMC 바로가기 [Article Type] Randomized Controlled Trial

An eight country cross-sectional study of the psychosocial effects of COVID-19 induced quarantine and/or isolation during the pandemic

Research

Published on 2022-08-012022-10-05
Journal: Scientific Reports [Category] 진단, 치료법,

Proficiency testing for SARS-CoV-2 whole genome sequencing

SARS-CoV-2 전체 게놈 시퀀싱 숙련도 테스트

Article

Published on 2022-08-012022-09-11
Journal: Pathology [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] accreditation acute respiratory syndrome Analysis approach bioinformatics Bioinformatics analysis Cluster consensus genome contribute coronavirus coronavirus 2 Critical dataset eight Extensive genomic implementation independent involved Laboratory molecular feature molecular features outcome Part positive proficiency testing public health Quality control question raw data reported required respiratory SARS-CoV-2 Sequencing Severe acute respiratory syndrome source of infection specimen Surveillance Transmission transmission route Transmission routes variant variants Variation WGS whole genome Whole genome sequencing
[DOI] 10.1016/j.pathol.2022.04.002 PMC 바로가기 [Article Type] Article

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis

COVID-19로 병원에 입원한 환자의 바리시티닙(RECOVERY): 무작위, 통제, 공개 라벨, 플랫폼 시험 및 업데이트된 메타 분석

Meta-Analysis

Published on 2022-07-302022-09-11
Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 임상,

[키워드] 1:1 28-day mortality 95% CI age-adjusted rate ratio allocation Baricitinib benefit by mouth cause Corticosteroid Corticosteroids COVID-19 COVID-19 therapy death deaths died discharge eight enrolled evaluate Evidence hospital hospitalised Including Infection inhibitor Innovation intention-to-treat population ISRCTN Jak JAK inhibitor jak inhibitors janus Janus kinase Medical Research Council Meta-analysis mouth nine Non-COVID-19 once daily Open-label outcomes Patient Platform trial Primary outcome Proportional reduction randomisation randomised randomised controlled trial Randomised Evaluation Randomly randomly assigned patient rate ratio receive receiving recorded recovery RECOVERY trial reduce mortality reduced reduction in mortality Registered risk of death significantly Standard of care suggested thrombosis Tocilizumab Treatment Trial trials usual care usual care alone usual care group was done with COVID-19
[DOI] 10.1016/S0140-6736(22)01109-6 PMC 바로가기 [Article Type] Meta-Analysis

Impact of a phone call with a medical student/general practitioner team on morbidity of chronic patients during the first French COVID-19 lockdown (COVIQuest): a cluster randomised trial

Randomized Controlled Trial

Published on 2022-07-282022-10-04
Journal: BMJ Open [Category] 임상,

Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies

신종 코로나바이러스에 대해 일반적으로 처방되는 항우울제의 강력한 항바이러스 활성: 시험관 내 및 실리코 약물 용도 변경 연구

Article

Published on 2022-07-282022-09-11
Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] activities activity amitriptyline anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Anti-viral antidepressant antidepressants antiviral activity clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Depression disorder disorders drug eating disorders effective Efficacy eight evaluated FDA-approved drug FDA-approved drugs FIVE imipramine in silico in vitro in vivo M pro MERS MERS-CoV migraine molecular docking studies Molecular docking study neuralgia pandemic Paroxetine Patient performed Prophylaxis protease reported symptom Result SARS-CoV-2 sertraline suggested symptomatic and asymptomatic symptoms of depression treating COVID-19 Treatment
[DOI] 10.1038/s41598-022-17082-6 PMC 바로가기 [Article Type] Article

Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation

인간 계면활성제 단백질 D는 DC-SIGN 발현 세포에서 SARS-CoV-2 유사형 결합 및 진입을 촉진하고 스파이크 단백질 유도 염증을 하향 조절합니다

Article

Published on 2022-07-282022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

[키워드] ACE2 Analysis Anti-viral binding carbohydrate cause Cell cell interaction cell line cell surface receptor cells chemokine chemokines collectins controls COVID-19 cytokine cytokine response Cytokines DC-SIGN dendritic cell domain downregulate downregulated eight epithelial expressing facilitate fragment of HEK 293T HEK293T cell HEK293T cells help Human IFN-α IL- 6 IL-1β IL-8 immune function immune response immunomodulatory effect increase independent independent of infection assay infection assays Inflammation inhibit SARS-CoV-2 innate immune innate immune system Interaction intercellular involved Macrophage macrophages MHC class MHC class II modulating mRNA expression mRNA level mRNA levels N-terminal naïve T cell naïve T cells NF-κB pathogen Pathogens pro-inflammatory cytokine pro-inflammatory cytokines Protein pseudotype RANTES receptors Replication rfhSP-D. RNA virus RT-qPCR SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein shown SIGN spike Spike protein surface receptor T cells the Spike THP-1 TNF-α treated Treatment Vero Cell Vero cells viral entry viruses
[DOI] 10.3389/fimmu.2022.960733 PMC 바로가기 [Article Type] Article

COVID-19 morbidity in Afghanistan: a nationwide, population-based seroepidemiological study

아프가니스탄의 COVID-19 이환율: 전국적인 인구 기반 혈청 역학 연구

Article

Published on 2022-07-272022-09-12
Journal: BMJ Open [Category] COVID19(2023년), MERS, SARS, 진단,