JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortalityJAK 억제는 SARS-CoV-2 간 감염성을 감소시키고 염증 반응을 조절하여 이환율 및 사망률을 감소시킵니다Observational Study Published on 2021-01-012022-09-11 Journal: Science Advances [Category] 신약개발, 임상, 진단, 치료제, [키워드] 95% CI ACE2 expression adverse events Antiviral antivirals Baricitinib benefit Cell cells Cohort controlled trials Culture cytokine Cytokine storm Efficacy elderly patients greater host protein host proteins human liver increase Inflammatory response inhibited inhibitor interferon Jak janus Janus kinase kinases liver liver cells median age Microscopy moderate-severe modulate morbidity and mortality Mortality outcome parenchymal parenchymal cells Patient platelet activation Pneumonia Randomized controlled trials reduce Replication reveal RNA-Seq SARS-CoV-2 SARS-CoV-2 pneumonia the cytokine storm Viral viral entry viral load quantification [DOI] 10.1126/sciadv.abe4724 PMC 바로가기 [Article Type] Observational Study
Hypercalcemia as a Biomarker of Poor Prognosis in Frail Elderly Patients with COVID-19COVID-19에 걸린 노쇠한 노인 환자의 불량한 예후의 바이오마커로서의 고칼슘혈증Article Published on 2021-01-012022-09-11 Journal: The journal of nutrition, health & aging [Category] MERS, 바이오마커, [키워드] Adults age albumin Antibiotics baseline Biomarker calcium Cardiomyopathy cohort study Concentration concentrations COVID-19 COVID-19 patients defined determine elderly elderly patients exhibited functional geriatric patients Health Hospital admission Hospitalized hypercalcemia hypertension Hypocalcemia less malignancies Mortality normocalcemia Older Older adults participant patients hospitalized Poor Prognosis respiratory SARS-CoV-2 Sex survival survival time survived were assessed with COVID-19 [DOI] 10.1007/s12603-021-1690-7 PMC 바로가기 [Article Type] Article
How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severityReview Published on 2021-01-012023-07-12 Journal: European journal of internal medicine [Category] SARS, [키워드] COVID19 elderly patients Geriatric care immunology [DOI] 10.1016/j.ejim.2020.11.024 PMC 바로가기 [Article Type] Review
The Use of Medical and Non-Medical Services by the Elderly during the SARS-CoV-2 Pandemic Differs between General and Specialist Practice: A One-Center Study in PolandArticle Published on 2020-12-232022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] analyzed assessment care coordination Coronavirus pandemic COVID-19 Decision-making Diseases effort elderly elderly patients Geriatrics Government had no Health professionals Healthcare needs IMPROVE include individual lack limitation observation pandemic Patient Poland quality of care questionnaire SARS-CoV-2 service significantly specialist the SARS-CoV-2 [DOI] 10.3390/healthcare9010008 PMC 바로가기 [Article Type] Article
Clinical features and risk factors for severe inpatients with COVID-19: A retrospective study in ChinaCOVID-19 중증 입원환자의 임상적 특징 및 위험인자: 중국에서의 후향적 연구Multicenter Study Published on 2020-12-172022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, [키워드] accompanied addition advanced age age age factor age factors albumin Asthma baseline Blood blood cell carried Cell Characteristics China clinical clinical information clinical symptom coronavirus coronavirus disease count COVID-19 COVID-19 patient COVID-19 patients Critical case critical cases cystatin C D-dimer decrease disaster distribution during treatment Efficacy Elderly patient elderly patients electronic medical record electronic medical records Epidemiological study ESR Factor faster feature female female patient Female patients Fever Gender Glucose group guideline hemoglobin hospital IMPROVE increase in inflammatory markers Inpatient Intervention IQR Kidney function Laboratory laboratory-confirmed Laboratory-confirmed COVID-19 liver liver and kidney function Logistic regression low-density Low-density lipoprotein lymphocyte male marker median age medical records neutrophil neutrophil count non-severe cases non-severe group Older outbreak oxygen oxygen saturation Patient patients with COVID-19 potential risk Prevent red blood cell researcher Result Retrospective study risk factor Risk factors Severe patient severe patients severity severity of COVID-19 shown Therapies treat Treatment White blood cell [DOI] 10.1371/journal.pone.0244125 PMC 바로가기 [Article Type] Multicenter Study
Prognostic Factors of COVID-19 Infection in Elderly Patients: A Multicenter StudyCommunication Published on 2020-12-042022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activity age C-reactive protein (CRP Chest clinical outcomes Comorbidity COVID-19 COVID-19 infection COVID-19 pandemic CRP daily living death defined died elderly Elderly patient elderly patients enrolled Factor Fatality rate Fever Health hospital Hospitalization impairment infiltration initial Logistic regression analysis multicenter multicenter study Novel coronavirus outbreak Oxygen treatment poor prognosis Population Prognosis Prognostic factor reduce Retrospective study risk factor robust SARS-CoV-2 severe pneumonia significantly South Korea the disease the patient understanding with COVID-19 [DOI] 10.3390/jcm9123932 PMC 바로가기 [Article Type] Communication
The effect of Tai Chi on the quality of life in the elderly patients recovering from coronavirus disease 2019 A protocol for systematic review and meta-analysis2019년 코로나바이러스 질병에서 회복 중인 노인 환자의 삶의 질에 대한 태극권의 효과 체계적인 검토 및 메타 분석을 위한 프로토콜Meta-Analysis Published on 2020-12-042022-09-10 Journal: Medicine [Category] MERS, SARS, 임상, [키워드] ability to participate approval blood circulation blood pressure Cardiopulmonary Chinese Chinese Biomedical Literature Database Chinese Clinical Trial Registry clinical clinical trials Cochrane Library Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient data extraction Effectiveness Elderly patient elderly patients Ethical approval Ethics evaluate Evidence immune function IMPROVE include information Infrastructure life literature Lung function mental health meta-analyses Meta-analysis Patient patient information patient rights physical positive protocol Quality Quality of life recovering from COVID-19 reflect Registration registry risk of bia Science Society statistical analysis systematic review Tai Chi technology [DOI] 10.1097/MD.0000000000023509 PMC 바로가기 [Article Type] Meta-Analysis
Patients with Covid-19 exhibit different immunological profiles according to their clinical presentationCovid-19 환자는 임상 양상에 따라 다른 면역학적 프로파일을 나타냅니다.Article Published on 2020-12-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome Admission Alpha analyzed Asymptomatic case Asymptomatic cases B cell B lymphocyte Beta beta coronavirus broad spectrum CD10 Cell Characteristics clinical Clinical presentations Clinical severity Comparisons complications coronavirus Coronavirus infection correlated COVID-19 cytokine Cytokines died difference disease expression Elderly patient elderly patients explain form group hospitalisation Hospitalization IL-1 IL-6 IL-8 immune response immunological immunological profile Infection lymphocyte marker Odds ratio outcome Patient Phenotypes plasma Predictive Ratio respiratory distress Respiratory distress syndrome responsible risk subject subpopulation Symptom symptom severity syndrome those who survived TNF-alpha were measured [DOI] 10.1016/j.ijid.2020.09.1438 PMC 바로가기 [Article Type] Article
Clinical characteristics and predictors of mortality associated with COVID-19 in elderly patients from a long-term care facilityObservational Study Published on 2020-11-302022-10-04 Journal: Scientific Reports [Category] SARS, 임상, 치료법, [키워드] age baseline cardiovascular disease Care Characteristics China clinical Clinical characteristics Cohort conducted coronavirus disease COVID-19 COVID-19 outbreak COVID-19 patient Cox regression analysis CVD Elderly patient elderly patients Epidemiology Hospitalized hypernatremia hypertension IL-6 in-hospital mortality in-hospital mortality rate independent predictor Infectious diseases interleukin-6 Lymphocyte count lymphopenia males Mortality Observational cohort study outbreak pandemic Patient predictor Prognostic factor reported retrospective SARS-COV-2 infection serum Serum level Spread with COVID-19 [DOI] 10.1038/s41598-020-77641-7 PMC 바로가기 [Article Type] Observational Study
Thymosin Alpha 1 Reduces the Mortality of Severe Coronavirus Disease 2019 by Restoration of Lymphocytopenia and Reversion of Exhausted T Cells티모신 알파 1은 림프구 감소증의 회복과 소진된 T 세포의 회복을 통해 심각한 코로나바이러스 질병 2019의 사망률을 감소시킵니다Article Published on 2020-11-192022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] (PD-1 Alpha benefit Blood CD4+ T cell CD4+ T cells CD4+ T-cell CD8+ CD8+ T cell CD8+ T cells circulation clinical benefit clinical benefits Clinical outcome clinical outcomes conditions COVID-19 COVID-19 patient COVID-19 patients domain elderly patients expression flow cytometry hospital immune immune reconstitution immune response Immunoglobulin Infection less lymphocytopenia marker mechanism mononuclear cell mononuclear cells Mortality mucin Patient PD-1 Peripheral blood Peripheral blood mononuclear cells protein 3 reduced respiratory restoration restored reversed reversion SARS-CoV-2 Severe acute respiratory syndrome severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly T cell T cells T-cell T-cell exhaustion T-cell receptor thymosin thymosin alpha 1 Treatment treatment for COVID-19 Viral viral infection viral infections was measured Wuhan Wuhan, China [DOI] 10.1093/cid/ciaa630 PMC 바로가기 [Article Type] Article