Population Genetics of SARS-CoV-2: Disentangling Effects of Sampling Bias and Infection ClustersSARS-CoV-2의 인구 유전학: 샘플링 편향 및 감염 클러스터의 풀림 효과Original Research Published on 2020-07-122022-09-11 Journal: Genomics, Proteomics & Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allele frequency approach Bia caused Cluster Clusters coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 downloaded Effect enrichment evolutionary dynamics Genetic genetic analysis Genetic polymorphism genomic sequence Haplotype Infection infection cluster lead mechanism Mutation mutation rate natural selection outbreak parameter Phylogenetic divergence Population Population genetic analysis respiratory responsible RNA virus robust sampling Sampling bias SARS-CoV-2 Seafood severe acute respiratory syndrome Coronavirus Spread the epidemic TMRCA trajectory Wuhan [DOI] 10.1016/j.gpb.2020.06.001 PMC 바로가기 [Article Type] Original Research
Evaluation of NGS-based approaches for SARS-CoV-2 whole genome characterisationRapid Communication Published on 2020-07-052022-10-28 Journal: Virus Evolution [Category] COVID-19, [키워드] Amplicon sequencing amplicon-based enrichment approach ARTIC Network bioinformatics capture method characterisation Complete consensus sequence Coverage COVID-19 COVID-19 outbreak DNA enrichment evaluated Genome genome coverage genomes Genomic surveillance Genomics identity Illumina metagenomic metagenomic sequencing next generation sequencing NGS ONT ORF6 Oxford Nanopore Technology Panel performed producing protocol reference sequence Region required respiratory respiratory sample SARS-CoV-2 sequenced Sequencing SNP threshold Viral load WGS whole-genome sequencing [DOI] 10.1093/ve/veaa075 PMC 바로가기 [Article Type] Rapid Communication
Possible SARS-coronavirus 2 inhibitor revealed by simulated molecular docking to viral main protease and host toll-like receptorResearch Article Published on 2020-06-122022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] adopted Analysis Antiviral applied binding energy COVID-19 determine enrichment functional protein GO and KEGG enrichment analysis Host Inflammatory inhibitor Interaction material metabolic process metabolism molecular docking MPro plants protease Protein rutin SARS-coronavirus SARS-CoV-2 main protease selected target therapeutic TLR TLR2 TLR6 TLR7 TLRs Toll-like receptor Toll-like receptors traditional antiviral medicinal plants [DOI] 10.2217/fvl-2020-0099 PMC 바로가기 [Article Type] Research Article
Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells대유행 완화제 후보의 삼자 조합: 인간 세포에서 SARS-CoV-2 표적의 게놈 유도 추적으로 정의된 COVID-19 대유행의 표적 완화를 위한 약제의 비타민 D, 케르세틴 및 에스트라디올 매니페스트 특성Article Published on 2020-05-212022-09-10 Journal: Biomedicines [Category] 비임상, [키워드] 2019 coronavirus disease ACE2 activity Affect agent Alter analyses Analysis breath build candidate cell types cellular clinical trial clinical trials Combination condition contribute coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 pandemic deficiency disease drug drugs drugs and medicinal substance repurposing Effect elements enrichment eriodictyol estradiol experiment expression expression profiling facilitate Follow-up function functions furin FURIN expression FURIN gene GATA5 gene expression profile Gene expression profiles gene expression signature Gene Set Enrichment Analyses gene silencing Genomics GSEA HIF1a high mortality HMGA2 HNF4A Human human body human cell human cells human gene human genes hypothetical identify Immediate Immune cell immune cells Immunosuppression Impact infect Infection Inference inhibitor inhibitors of SARS-CoV-2 INSIG1 interfere Intervention intrinsically Luteolin majority male Mitigation mitigation approaches molecular Mortality observation observational study observations Older overexpression pandemic Panel Patient persistence present property Protein Protein target protein targets Proteins quercetin Randomized randomized clinical trial Regulatory reported repressor required RUNX1 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral selective severity SFTPC smoking Spread SUMMIT drug-docking screen target targets Testosterone the SARS-CoV-2 tissues tracing Transgenic mouse Treatment upstream utility Viral Viral protein Viral proteins virus Vitamin D vitamin D deficiency website [DOI] 10.3390/biomedicines8050129 PMC 바로가기 [Article Type] Article
scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli CellsArticle Published on 2020-04-092022-10-31 Journal: Cells [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 category cell entry receptor China coronavirus COVID-19 patient digestive downregulated enrichment Evidence expression pattern Gene ontology GO term GSEA Human indicate Infection male Novel coronavirus pathophysiology Presence Profiling provided rapidly spreading disease reproductive SARS-CoV SARS-CoV-2 SARS-COV-2 infection scRNA-seq sequence similarity Sertoli Sertoli cells single-cell transcriptomes spermatogonia target Teste Transmission Wuhan [DOI] 10.3390/cells9040920 PMC 바로가기 [Article Type] Article
Discovery of Bat Coronaviruses through Surveillance and Probe Capture-Based Next-Generation SequencingResearch Article Published on 2020-01-292022-10-30 Journal: mSphere [Category] Coronavirus, [키워드] acute respiratory syndrome approach bat bat coronavirus bats caused coronavirus CoV CoVs eight enrichment feasible genetic diversity Genome Homologous recombination Human humans increase methodology Middle East mitigate Next-generation sequencing NGS nine Outbreaks Pandemics PCR Performing predict reduced sensitivity sequence Sequencing Surveillance syndrome virus [DOI] 10.1128/mSphere.00807-19 PMC 바로가기 [Article Type] Research Article
Rapid detection of trace Salmonella in milk and chicken by immunomagnetic separation in combination with a chemiluminescence microparticle immunoassayarticle Published on 2019-09-302024-09-01 Journal: Analytical and Bioanalytical Chemistry [Category] 살모넬라증, [키워드] chemiluminescence immunoassay enrichment food safety pathogen pretreatment [Article Type] article
Efficient synchronization of Plasmodium knowlesi in vitro cultures using guanidine hydrochloride구안디딘 염산염을 이용한 플라스모디움 노엘시의 효율적인 인 비트로 배양 동기화Methodology Published on 2019-04-252024-08-11 Journal: Malaria Journal [Category] 말라리아, [키워드] Culture enrichment guanidine hydrochloride Plasmodium knowlesi Ring sorbitol synchronization [DOI] 10.1186/s12936-019-2783-1 PMC 바로가기 [Article Type] Methodology
Isolation and Full-Genome Characterization of Nipah Viruses from Bats, BangladeshArticle Published on 2019-01-012023-05-31 Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] Bangladesh bats enrichment full-genome characterization henipavirus Isolation Next-generation sequencing Nipah virus Pteropus medius viruses zoonoses [DOI] 10.3201/eid2501.180267 PMC 바로가기
Machine learning identifies signatures of host adaptation in the bacterial pathogen Salmonella enterica기계 학습은 박테리아 병원체 Salmonella enterica에서 숙주 적응의 신호를 식별합니다Research Article Published on 2018-05-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 살모넬라증, [키워드] analyses Analysis approach architecture Atypical bacterial pathogen Bacterial pathogens bacterial specy build captures change changes in Classifier complex interaction continuum convergence data sets Degradation detect disease disease phenotype Disease surveillance dissect enrichment Epidemic epidemiological purposes functional Gastrointestinal infection Genes genome sequence genomic data high mortality HIV host adaptation host range identify Immunocompromised implementation Inclusion Infection input invasive invasive disease lead Lineage lineages machine member metabolic pathway metabolic pathways Mortality Mutation New outcome pathogen pathogenic Pathogens phenotype Population predict Predictive protein coding gene protein coding genes public health random Random forest rare variant Rare variants required Salmonella Salmonella Enteritidis scaled sequence Sequencing shift species strain Strains sub-Saharan Africa Surveillance [DOI] 10.1371/journal.pgen.1007333 PMC 바로가기 [Article Type] Research Article