Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting WuhanOriginal Articles Published on 2020-01-282022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus 2019-nCoV 2019-nCoV infection Amino acid Antiviral Atypical Betacoronavirus bioinformatics Bioinformatics analysis China coronavirus coronavirus genomes diagnostic emerging ENCODE envelope Evolution Genome identity Infection learning MERS Novel coronavirus novel lineage nucleoprotein nucleotide outbreak Pathogenesis Patient performed Phylogenetic tree Pneumonia Protein Receptor binding domain respiratory SARS SARS coronaviruses SARS-CoV SARS-related coronaviruses secreted protein spike Vaccination strategy virus virus genome World Health Organization Wuhan [DOI] 10.1080/22221751.2020.1719902 PMC 바로가기 [Article Type] Original Articles
Virological Factors Associated With the Occurrence of Hepatitis B Virus (HBV) Reactivation in Patients With Resolved HBV Infection Analyzed Through Ultradeep SequencingArticle Published on 2020-01-142023-06-12 Journal: The Journal of Infectious Diseases [Category] B형 간염, [키워드] envelope Genotype Mutation NGS reactivation. [DOI] 10.1093/infdis/jiz478 PMC 바로가기
Analysis of the Genome Sequence and Prediction of B-Cell Epitopes of the Envelope Protein of Middle East Respiratory Syndrome-CoronavirusArticle Published on 2018-07-012022-10-29 Journal: IEEE/ACM transactions on computational biology and [Category] Coronavirus, MERS, [키워드] 3D structure amino acids sequence analyzed B cell epitope B-cell epitope bioinformatics China conserved database death E protein effective envelope epitope genome sequence highly antigenic Host Human identify IMPROVE Infection lack linear B-cell epitope MERS MERS-CoV Middle East NCBI nucleotide outbreak Pandemics Patient PDB predict predicted prediction Protein PyMol respiratory Sequence analysis significantly South Korea strain triggered Vaccine development was performed were used X-ray [DOI] 10.1109/TCBB.2017.2702588 PMC 바로가기 [Article Type] Article
Common and Distinct Capsid and Surface Protein Requirements for Secretion of Complete and Genome-Free Hepatitis B VirionsArticle Published on 2018-06-292023-06-16 Journal: Journal of Virology [Category] B형 간염, Fulltext, [키워드] capsid complete virion empty virion envelope hepadnavirus Hepatitis B virus virus secretion. [DOI] 10.1128/JVI.00272-18 PMC 바로가기
The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral PathogenesisResearch Article Published on 2014-08-142022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activating Activation acute respiratory syndrome addition administration analyses assays caused Cell cellular complementary confocal microscopy coronavirus cytoplasm decrease decreased expression Deleterious demonstrated determinant domain E protein Elimination envelope Epidemic exacerbated functional genetics highlight immune response immunopathology in vivo increase in induce infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibitor interact Interaction interactions involved lung lung damage MAPK mice modulating Mortality motif nucleus overexpression parental pathway potential therapeutic target Protein Proteins proteomic recombinant reduce reduction in respiratory SARS-CoV SARS-CoV E SARS-CoV infected cells SARS-CoV infection siRNA survival triggered triggering virulence virus virus virus attenuation was reduced yeast [DOI] 10.1371/journal.ppat.1004320 PMC 바로가기 [Article Type] Research Article
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and PathogenesisResearch Article Published on 2014-05-012022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence accompanied Activation activity acute respiratory distress Affect airway Amino acid ARDS assays ATPase attenuate Cell channel compensatory mutation complexes Concentration correlated Critical cytokine cytosolic death Deletion demonstrated died disease Diseases displaying E gene E protein edema ENCODE envelope eventually death experiment fitness highly pathogenic IL-1β IL-6 in viral induce inducer Infection infections Inflammasome inflammasome activation Inflammatory cytokine Inflammatory response innate immune system Interaction involved Ion ion homeostasis less Level lost weight lung lung damage lung epithelia macromolecular maturation mechanism mice multifunctional protein mutant mutant viruses Mutation outcome Pathogenesis pathology produced progression promote Protein pulmonary damage reduced reducing required respiratory restored SARS-CoV SARS-CoV E SARS-CoV infection sequence severe hypoxemia significantly suppressed survived syndrome therapy this system TNF translated transmembrane protein Transport viral infection virulence virus virus virus growth virus pathogenesis virus production wild-type [DOI] 10.1371/journal.ppat.1004077 PMC 바로가기 [Article Type] Research Article
Performance and clinical validation of the RealStar ® MERS-CoV Kit for detection of Middle East respiratory syndrome coronavirus RNA중동 호흡기 증후군 코로나바이러스 RNA 검출을 위한 RealStar ® MERS-CoV 키트의 성능 및 임상 검증Article Published on 2014-03-282022-09-25 Journal: Journal of Clinical Virology [Category] MERS, 진단, [키워드] Altona Diagnostics amplification analytical sensitivity assays clinical sample comparable coronavirus cross-reactivity Diagnosis diagnostic assay Diagnostic method envelope Epidemiology Frame genomic region Germany Hamburg highly pathogenic IMPROVE Internal control management MERS-CoV MERS-CoV infection MERS-CoV RNA Middle East Middle East respiratory syndrome molecular Munich nucleic acid objective ORF Patient PCR performance real-time RT-PCR Respiratory disease respiratory diseases respiratory pathogen respiratory sample respiratory syndrome coronavirus Result RNA RT-PCR assay RT-PCR kit target region upstream virus WHO World Health Organization [DOI] 10.1016/j.jcv.2014.03.012 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and ApoptosisResearch Article Published on 2011-10-202022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence activating Activation acute respiratory syndrome addition alleviate Apoptosis apoptotic Author Cell cell metabolism cell stress cells compared contribute contributed control cell different dissemination down-regulated drug drugs E gene E protein elicit envelope enzyme expressing expression Factor Gene Gene Expression homeostasis Host host gene expression identify immunoregulation in vivo increase in Infected Infection Inflammation involved lack mechanisms mutant pathway Pathways potential mechanism proinflammatory Proinflammatory cytokine PROTECT Protein reduced reduction reduction in regulated respiratory respiratory syncytial virus response reversed SARS-CoV SARS-CoV E severe Signal transduction signaling pathway Stress subset Transcription transcription factor treated Treatment unfolded protein response upregulated virus virus production was reduced [DOI] 10.1371/journal.ppat.1002315 PMC 바로가기 [Article Type] Research Article
Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion ChannelResearch Article Published on 2009-07-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome affecting alteration Anti-viral drugs antiviral strategy Author binding site C-terminal Cell channel characterized common cold coronavirus coronavirus coronavirus protein described determined distribution drug design E protein embryonic kidney envelope envelope protein event expressed expressing feature form found full length HEK-293 Human humans in vitro inactivation infect inhibited inhibition Ion lethal disease mammalian cell mammals membrane Mild morphology N-terminal NMR pandemic Pathogenesis pharmacological target platform produced Protein Proteins provide reduced reported responsible SARS-CoV SARS-CoV E shown significantly Structure supported transmembrane domain Validity variety viral envelope viral pathogen viral replication virion virus viruses [DOI] 10.1371/journal.ppat.1000511 PMC 바로가기 [Article Type] Research Article