The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2SARS-CoV와 SARS-CoV-2 사이의 다양한 보존된 에피토프를 표적으로 하는 항체의 중화 폭Article Published on 2022-08-232022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] antibody Antibody therapeutics Beta Beta variant breadth broad neutralizing antibody Candidates class complex conserved conversed epitopes COVID-19 cross-neutralizing antibody cryo Cryo-electron microscopy defined Delta effective electron microscopy epitope Epitopes evade exhibited hamsters immunization Infection Microscopy NAb NAbs neutralization Neutralizing Neutralizing antibodies neutralizing antibody offer omicron Omicron variant Omicron variants pseudoviruses Receptor-binding domain SARS-CoV SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody Spike proteins Structure the receptor-binding domain the spike protein Treatment treatment of COVID-19 Vaccine variant variants variants of concern variants of SARS-CoV-2 Viral [DOI] 10.1073/pnas.2204256119 PMC 바로가기 [Article Type] Article
A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination감염 및 백신 접종 후 표적화된 SARS-CoV-2 스파이크의 SD1 도메인에 대한 중화 에피토프Article Published on 2022-08-232022-09-12 Journal: Cell Reports [Category] SARS, 진단, [키워드] acute respiratory syndrome antibody bind canonical coronavirus CP: Immunology CP: Microbiology Cryo-electron microscopy cryo-EM cryogenic electron microscopy domain elicited epitope glycoprotein hydrogen-deuterium exchange identify Immune escape Infection N-terminal domain neutralization Neutralizing Neutralizing antibodies neutralizing antibody neutralizing epitope NTD omicron predominant prefusion RBD Receptor binding domain Region Research SARS-CoV-2 SARS-CoV-2 spike shown spike subdomain 1. target the SARS-CoV-2 vaccination Vaccine development while [DOI] 10.1016/j.celrep.2022.111276 PMC 바로가기 [Article Type] Article
Considering epitopes conservity in targeting SARS-CoV-2 mutations in variants: a novel immunoinformatics approach to vaccine design변이체에서 SARS-CoV-2 돌연변이 표적화에서 에피토프 보존성 고려: 백신 설계에 대한 새로운 면역정보학 접근Article Published on 2022-08-182022-09-11 Journal: Scientific Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity antibody antigenicity approach Avian flu calculated collected conserved Coronavirus-2 database Developing Efficacy epitope Epitopes event flu ideal identify IEDB immune Immune Epitope Database Immunity immunodominant immunogenicity immunoinformatics mutated Mutation mutations neutralization pathogenicity platform predicted preference provide reduce Region SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 mutation selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Shannon entropy similarity solution technique Vaccine design Vaccines variant variants virulence virus viruses [DOI] 10.1038/s41598-022-18152-5 PMC 바로가기 [Article Type] Article
A platform technology for generating subunit vaccines against diverse viral pathogensArticle Published on 2022-08-182022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] acting affinity tag animal model Antigen binding can be used Clamp conformation COVID-19 pandemic Ebola virus elicit epitope fusion fusion protein glycoprotein immune response immunologically Infectious disease MERS-CoV Microscopy middle molecular monoclonal antibody mRNA neutralising Neutralising Antibodies Nipah virus offer platform precursor prefusion purification reagent remained respiratory syndrome coronavirus shown size exclusion chromatography stability stimulated Streamline subunit Subunit vaccine subunit vaccines tested trimeric Vaccine vaccine candidate vaccine platform Viral Viral antigen viral challenge viral pathogen virus [DOI] 10.3389/fimmu.2022.963023 PMC 바로가기
SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization우려되는 SARS-CoV-2 변이체: 스파이크 단백질 돌연변이 분석 및 광범위한 중화를 위한 에피토프Article Published on 2022-08-182022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] Analysis antibody Antibody neutralization antigenic binding circulating variants Comparative analysis consequence convalescent sera cryo-EM Effect ENhance epitope exhibit functional Gamma highlight identify mutated Mutation N-terminal domain neutralization neutralize NTD omicron RBD SARS-CoV-2 spike SARS-CoV-2 spike mutations SARS-CoV-2 variant SARS-CoV-2 variants shown spike glycoprotein spike glycoproteins Spike protein structural rearrangements unique variant variant spike [DOI] 10.1038/s41467-022-32262-8 PMC 바로가기 [Article Type] Article
A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD Correspondence Published on 2022-08-172022-10-05 Journal: Cell Discovery [Category] 변종, [키워드] epitope neutralizing antibody SARS-CoV-2 RBD target unique VoC VOI [DOI] 10.1038/s41421-022-00443-w [Article Type] Correspondence
Resolving SARS-CoV-2 CD4 + T cell specificity via reverse epitope discovery역 에피토프 발견을 통한 SARS-CoV-2 CD4 + T 세포 특이성 해결Meta-Analysis Published on 2022-08-162022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen approach CD4 CD4 T cells Cluster coronavirus COVID-19 dataset detect epitope epitope discovery FIVE functional cell HLA identify immunodominant individual infected individuals information Intensive labor leukocyte Meta-analysis pathogen peptide peptide pool public T cell response. recognizing responses SARS-CoV-2 sequence similarity severe acute respiratory syndrome Coronavirus similarity single-cell specificity T cell T cell receptor T cell receptors T cell response T cells TCR TCR repertoire TCRs These data transgenic utility [DOI] 10.1016/j.xcrm.2022.100697 PMC 바로가기 [Article Type] Meta-Analysis
Platform for Active Vaccine Formulation Using a Two-Mode Enhancement Mechanism of Epitope Presentation by Pickering Emulsion피커링 에멀젼에 의한 에피토프 제시의 2-모드 향상 메커니즘을 사용한 활성 백신 제형을 위한 플랫폼Article Published on 2022-08-152022-09-12 Journal: ACS applied bio materials [Category] SARS, 진단, [키워드] Administered ambient antigenic Antisera applied approach Concentration conditions conjugate correlated determinants Efficacy Efficiency Emulsion enhancement epitope epitope-based vaccination Formulation heterogeneity IgG IgG titer Immunoglobulin include magnitude Pathogens peptide Pickering emulsion plant virus platform presentation subsequent subunit subunit vaccines vaccination Vaccine development Virus-like-particles. vivo assay VLPs [DOI] 10.1021/acsabm.2c00410 PMC 바로가기 [Article Type] Article
Can machines learn the mutation signatures of SARS-CoV-2 and enable viral-genotype guided predictive prognosis?기계가 SARS-CoV-2의 돌연변이 신호를 학습하고 바이러스 유전자형 유도 예측 예후를 가능하게 할 수 있습니까?Article Published on 2022-08-152022-09-11 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, [키워드] accumulation added Additive age approach Can caution changes in clade cleaning Continuous driving epitope Epitopes Factor Features Genome genomes genomic data Genotype genotypic global healthcare hallmark HLA Implications Infection information Interaction life threatening machine machine learning machine-learning mutated Mutation Mutation identification mutations nucleotide Pathogens performed Predictive Predictive prognosis Prognosis representing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severity Temporal Temporal benchmarking. Total variant variants Viral diseases virus [DOI] 10.1016/j.jmb.2022.167684 PMC 바로가기 [Article Type] Article
Antibodies against the SARS-CoV-2 S1-RBD cross-react with dengue virus and hinder dengue pathogenesisArticle Published on 2022-08-152022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] acute respiratory syndrome addition anti-SARS-CoV-2 antibody Antibody-dependent enhancement antigenic bleeding controls coronavirus COVID-19 COVID-19 patient cross-protection cross-react cross-reactive antibody cross-reactivity dengue patient dengue virus Diagnosis disease disease severity domain endothelial envelope protein epitope False-positive hyperimmune IgG in vitro induce Infection inhibited mice Neutralizing nonstructural protein 1 passive transfer Pathogenesis peptide promote purified random reaction reduced reported SARS-CoV-2 SARS-COV-2 infection sera serology test significantly increased Spike protein Spread the SARS-CoV-2 [DOI] 10.3389/fimmu.2022.941923 PMC 바로가기