Extracellular pH, osmolarity, temperature and humidity could discourage SARS-CoV-2 cell docking and propagation via intercellular signaling pathwaysBiochemistry Published on 2021-10-112022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] addition approach biochemical evidence Cell clinical investigation clinical trials country COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine Critical disease Diseases docking dose Economic medical device endpoints example Extracellular Factor Factors Frequency help high mutation rate highlight identify implication Infection intercellular Intervention long-lasting Malta osmolarity pandemic pathway Preventive therapy Proteases rapid increase Research SARS-CoV-2 SARS-CoV-2 cell sialic acid signaling pathway sodium Support temperature therapeutic intervention Treatment User-friendly therapy vaccination vaccination rate vascular permeability viral cell virus virus infection virus variant warm [DOI] 10.7717/peerj.12227 PMC 바로가기 [Article Type] Biochemistry
Commonalities Between ARDS, Pulmonary Fibrosis and COVID-19: The Potential of Autotaxin as a Therapeutic TargetARDS, 폐 섬유증 및 COVID-19 사이의 공통점: 치료 표적으로서의 Autotaxin의 가능성Review Published on 2021-10-042022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] acute respiratory distress ARDS Autotaxin characterized COVID-19 death develop Effect Endothelial dysfunction Extracellular fibroproliferative response Hospitalization hyperinflammation ILD immune cells increased risk LPA Lung disease lysophosphatidic acid lysophospholipid multi organ failure pathologic pleiotropic Potential pulmonary pulmonary fibrosis responsible secreted severe disease Signaling similarity subset surviving patient syndrome target therapeutic target [DOI] 10.3389/fimmu.2021.687397 PMC 바로가기 [Article Type] Review
Evaluation of a multiplexed coronavirus antigen array for detection of SARS-CoV-2 specific IgG in COVID-19 convalescent plasmaCOVID-19 회복기 혈장에서 SARS-CoV-2 특이 IgG 검출을 위한 다중 코로나바이러스 항원 어레이 평가Article Published on 2021-10-012022-09-11 Journal: Journal of Immunological Methods [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Antibody Response Antibody test Antibody titers Antigen Antigen array antigens comparable convalescent plasma convalescent plasma samples coronavirus COVID-19 COVID-19 pandemic cross-reactivity domain ELISA ELISAs Endemic evaluated Extracellular focus FRNT full-length HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HKU1 IgG IgG antibody Inc InDevR lack Live virus MERS MERS-CoV Mitigation Neutralizing activity neutralizing antibody neutralizing antibody titers NL63 nucleocapsid nucleocapsid IgG OC43 other coronavirus other coronaviruses plasma samples platform positive result positive sample proximal question reactivity Receptor binding domain reduction remained reported Sample SARS-CoV SARS-CoV spike SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-CoV-2 nucleocapsid Sensitivity and specificity significantly higher specificity spike Spike antigen the antibody response the SARS-CoV-2 while [DOI] 10.1016/j.jim.2021.113104 PMC 바로가기 [Article Type] Article
Inhaled [D-Ala 2 ]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung InjuryResearch Article Published on 2021-09-272022-10-29 Journal: Journal of Immunology Research [Category] COVID-19, [키워드] abrogate acute lung injury acute respiratory distress airway epithelial cell ARDS bind Box caused cellular chemokines COVID-19 Critical Cytokine storm Cytokines cytoplasm disease severity Effect endothelial cells enzyme expression Extracellular group HMGB1 HMGB1 release HMGB1 secretion identify immune cells Inflammatory Inflammatory mediators Inhaled inhibit life-threatening lung Lung diseases lysine mechanism of action mice Mobility Model modulation mouse nuclear nucleus occur peptide Pneumonia posttranslational modifications Proinflammatory cytokine Protein pulmonary inflammation RAGE receptors redox state Release released residue respiratory infection significantly SIRT1 syndrome the SARS-CoV-2 virus therapeutic TLR4 toll-like receptor 4 translocation treating COVID-19 Treatment [DOI] 10.1155/2021/4414544 PMC 바로가기 [Article Type] Research Article
Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas림프종의 분리 된 경우에서 SARS-COV-2에 의한 희귀 항 종양 면역 반응의 잠재적 분자 메커니즘Article Published on 2021-09-252022-09-01 Journal: Viruses [Category] SARS, 유전자 메커니즘, 진단, [키워드] anti-tumor immune response anti-tumor immunotherapy Apoptosis approach B-cell binding binding site Cancer CD27 CD45 cell proliferation classical Complete Complete Remission complex component domain Extracellular follicular Follicular lymphoma gamma-tubulin ring complex Hodgkin lymphoma induce inhibit initial interact interacting residues internalization Isolated lymphoma lymphoproliferative disorders M pro M protein membrane microtubule molecular mechanism monoclonal antibodies monoclonal antibody motif NF-kB nivolumab nsp10 Nsp7 oncogenesis ORF3a ORF3a protein PD-1 Pembrolizumab Potential Protein Proteins receptor Remission reported response responsible SARS-CoV-2 SARS-COV-2 infection Signaling the SARS-CoV-2 therapeutic potential TRADD TUBG1 virus [DOI] 10.3390/v13101927 PMC 바로가기 [Article Type] Article
Increased Autotaxin Levels in Severe COVID-19, Correlating with IL-6 Levels, Endothelial Dysfunction Biomarkers, and Impaired Functions of Dendritic Cells중증 코로나19에서 증가된 오토탁신 수치, IL-6 수치, 내피 기능 장애 바이오마커 및 수지상 세포 기능 손상과 상관관계Article Published on 2021-09-162022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] ARDS Autotaxin autotaxin (ATX; ENPP2) Biomarkers cohorts correlated COVID-19 COVID-19 pathogenesis COVID-19 patients Cytokine storm dataset dendritic cells dendritic cells (DCs) Dexamethasone endothelial damage ENPP2 expression Extracellular fibrosis function functional homeostasis Hospitalization hyperinflammation IL-6 Immune cell immune cells Impaired include Increased independent Inflammation Level LPA lysophosphatidic acid (LPA) mechanically ventilated mechanically ventilated patient mechanically ventilated patients mRNA level multifunctional Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples pathologic pharmacological pleiotropic pulmonary fibrosis pulmonary injury reduced RNA sequencing scale analysis secreted Serum level severe COVID-19 patients shown Signaling Single Cell suggested suppression Therapeutic benefit therapeutic benefits therapeutic option Treatment vascular dysfunction [DOI] 10.3390/ijms221810006 PMC 바로가기 [Article Type] Article
Novel ACE2 protein interactions relevant to COVID-19 predicted by evolutionary rate correlationsBioinformatics Published on 2021-09-152022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] ACE2 ACE2 protein ACE2 receptor affecting androgen approach bind biological interaction candidate caused cell receptor Chronic illness clusterin Coagulation coagulation pathways coevolution component connection contributing to coronavirus coronavirus SARS-CoV-2 correlated correlation COVID-19 cytokine signaling Cytokine storms detect disease manifestation enzyme ERC Evolution Evolutionary inference Evolutionary rate Extracellular factor V FGA FGB FGG fibrinogen function GPR141 human cells identify IFNAR2 immune response Immunity infect Inflammatory response information interact Interaction interactions involved mammalian mammalian protein novel organ systems pandemic disease pathogen Pathologies pathology pathway predict predicted Protein protein interaction Protein networks Proteins reported Respiratory disease SARS-COV-2 infection severe COVID-19 suggestion the disease TLR8 Treatment XCR1 [DOI] 10.7717/peerj.12159 PMC 바로가기 [Article Type] Bioinformatics
Role of intestinal extracellular matrix-related signaling in porcine epidemic diarrhea virus infectionResearch Article Published on 2021-09-132022-10-28 Journal: Virulence [Category] Coronavirus, [키워드] activated activating antimicrobial peptide antiviral activity antiviral cytokine CD44 clinical Cluster cluster of differentiation 44 differentially expressed gene dysfunction ECM enterocytes epidemic diarrhea exhibited expression Extracellular Extracellular matrix Genes high mortality rate IL-11 IL-18 Infection Interaction intestinal intestinal epithelial cell intestinal tissue intestine investigated lesions mechanism network analysis nuclear Pathways PEDV Porcine epidemic diarrhea virus positive correlation potential therapeutic target progeny virion promote Replication resulting role serpin family E member 1 SERPINE1 Signaling significantly structural framework transcriptional level viral infection Viral load viral release viral replication virus virus infection [DOI] 10.1080/21505594.2021.1972202 PMC 바로가기 [Article Type] Research Article
Histone H3 Cleavage in Severe COVID-19 ICU PatientsCellular and Infection Microbiology Published on 2021-09-102022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] Acute kidney injury Admission complex coronavirus disease COVID-19 damage-associated molecular pattern DAMPs DAMPs (damage-associated molecular patterns) Evolution Extracellular Extracellular histones histone ICU ICU - Intensive care unit ICU admission ICU Patients Infection Inflammatory diseases invasive ventilation marker MPO NET NETosis neutralization Neutrophil extracellular trap Patient patients plasma progression reduce released remained severe COVID-19 patients severity significantly increased subset Support targeted therapy the patient Thromboembolic event Treatment Validity Vasoactive [DOI] 10.3389/fcimb.2021.694186 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
A Comprehensive Insight into the Role of Exosomes in Viral Infection: Dual Faces Bearing Different FunctionsReview Published on 2021-09-042022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] addition Bearing biogenesis biological processe Cell cellular cellular immunity cellular molecules component Comprehensive downstream element EVs Exosome Exosomes Extracellular extracellular vesicles (EVs) face Factor function immune evasion immune modulation immune response in viral Infection influence insight lipids manuscript microenvironment modulate pathogenesis and immune modulation pathogenic virus pathway physiological Proteins provided RNAs role therapeutic strategy thought Transport understanding Vaccine variety Vesicle viral infection viral infections viral propagation virus [DOI] 10.3390/pharmaceutics13091405 PMC 바로가기 [Article Type] Review