Isolation of Viable SARS-CoV-2 Virus from Feces of an Immunocompromised Patient Suggesting a Possible Fecal Mode of TransmissionArticle Published on 2021-06-182022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Cell culture Cluster Corona coronavirus 2 COVID-19 diarrhea enteric virus Epidemic Evidence fecal Fece gastrointestinal tract immunosuppressive Infectious virus isolate kidney kidney transplant mode organ transplantation Particle Patient patients respiratory RT-PCR SARS-CoV-2 Stool stools therapy transmission of SARS-CoV-2 unique Viable virus [DOI] 10.3390/jcm10122696 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Host Receptor ACE2 Protein Expression Atlas in Human Gastrointestinal TractCell and Developmental Biology Published on 2021-06-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 ACE2 protein acute respiratory syndrome analyzed antibody Atla Cancer cancer cell cancers CCK-8 cells Colon Colon cancer coronavirus correlation counting death digestive distribution enzyme expressed expression expression level expression pattern Gastrointestinal gastrointestinal cancers gastrointestinal tract heterogeneous host cell Human IHC immunohistochemistry in vitro independent infect infected with SARS-CoV-2 Interaction liver Liver cancer not affect not correlated pancreas pancreatic Pancreatic cancer paraffin-embedded Patient Prognosis prognosis of patient Prognostic marker proliferation proportion protein expression receptor Result SARS-CoV-2 significantly significantly increased staining survival Symptoms tissue tissues tract tumor cell line was tested [DOI] 10.3389/fcell.2021.659809 PMC 바로가기 [Article Type] Cell and Developmental Biology
Pathophysiology and possible treatments for olfactory-gustatory disorders in patients affected by COVID-19Review article Published on 2021-06-052022-10-05 Journal: Current Research in Pharmacology and Drug Discovery [Category] 치료법, [키워드] ACE2 ACE2 receptor addition affected Ageusia alveolar epithelial cell alveolar epithelial cells Anosmia approach Bronchial epithelium cause changes in Clinical management co-expression COVID-19 decrease described disorder disorders effective therapy Evidence expressed gastrointestinal tract host cell implication include infect influence Interaction intranasal involved knowledge Loss of Smell mechanism nasal olfactory olfactory disorder olfactory dysfunction omega-3 pathophysiology Patient patients with COVID-19 pharmacological Protein receptor SARS-CoV-2 sensitivity sensory neuron shown sialic acid Smell sodium specific treatment spike Taste Therapeutics therapy TMPRSS2 transmembrane serine protease treat Treatment virus vitamin A [DOI] 10.1016/j.crphar.2021.100035 [Article Type] Review article
Hydrotalcite–Niclosamide Nanohybrid as Oral Formulation towards SARS-CoV-2 Viral InfectionsArticle Published on 2021-05-192022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] administration affecting Anti-viral approved characterized coated with Concentration COVID-19 Critical determine develop drug candidates effective Efficacy ENhance FDA Formulation gastrointestinal tract HPMC hydrotalcite in vitro in vivo indicated individual methyl cellulose nanohybrid NIC niclosamide oral oral formulation pandemic pharmacokinetic pharmacokinetics plasma required SARS-CoV-2 therapeutic therapeutic strategy treating COVID-19 tween [DOI] 10.3390/ph14050486 PMC 바로가기 [Article Type] Article
Recovery of SARS-CoV-2 from Wastewater Using Centrifugal UltrafiltrationProtocol Published on 2021-05-122022-10-30 Journal: Methods and Protocols [Category] COVID-19, [키워드] ACE-2 angiotensin-converting enzyme 2 Castle cause Centrifugal clinical clinical testing collected Community Concentration costly COVID-19 COVID-19 pandemic COVID-19 surveillance disease enteric virus evaluate fluctuation gastrointestinal tract genomic genomic RNA Human infected individual monitoring New populations processed protocol provide receptor replicate Research RT-qPCR SARS-CoV-2 Spread spreads Surveillance target the disease Ultrafiltration Urine virus wastewater [DOI] 10.3390/mps4020032 PMC 바로가기 [Article Type] Protocol
Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders2형 면역 및 연령은 호산구성 위장 장애에서 코로나바이러스 유발 질병 2019 수용체의 유전자 발현을 수정합니다Article Published on 2021-05-012022-09-11 Journal: Journal of pediatric gastroenterology and nutritio [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus age airway analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 atopic caused children Coronavirus-2 COVID-19 datasets decreased expression disease disorder Effect enzyme Eosinophilic eosinophilic gastritis esophagitis expression gastritis Gastrointestinal gastrointestinal tract Gene Expression GI Tract host cell host cells Immunity Infection Inflammation Inflammatory inflammatory condition inflammatory conditions no difference pediatric portal Protective RNA-sequencing SARS-CoV-2 Serine serine protease serine protease TMPRSS2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly lower tissue TMPRSS2 Type viral entry [DOI] 10.1097/MPG.0000000000003032 PMC 바로가기 [Article Type] Article
Effects of SARS-CoV-2 on Cardiovascular System: The Dual Role of Angiotensin-Converting Enzyme 2 (ACE2) as the Virus Receptor and Homeostasis Regulator-ReviewReview Published on 2021-04-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE inhibitor ACE-2 ACE2 ACE2 expression ACEi/ARB acute respiratory distress acute respiratory syndrome ADAM17 age alveolar Angiotensin II appear ARBs ARDS blocker cardiovascular cardiovascular disease cardiovascular system Cell cleavage Comorbidities Comorbidity coronavirus disease-2019 Coronavirus-2 COVID-19 COVID-19 mortality COVID-19 vaccine CVD domain driven by ectodomain Effect entry receptor enzyme excessive immune response expressed gastrointestinal tract Gender genetics homeostatic host cell humans immune response immune systems Interaction Leydig cell Lung epithelial cells multi-organ failure pandemic Patient priming Protein provide RAS renal tubular epithelium renin-angiotensin system required resulting role SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike spike glycoprotein syndrome TMPRSS2 transmembrane Treatment turn type I Vaccines vascular endothelial cells [DOI] 10.3390/ijms22094526 PMC 바로가기 [Article Type] Review
Correlation of Severity of COVID-19 Disease With Gastrointestinal Manifestations and Liver Injury – A North Brooklyn Community Hospital Experience: A Retrospective Cohort StudyGastroenterology Published on 2021-04-182022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 30-Day mortality 95% confidence interval ACE-2 acute respiratory syndrome Alanine ALT angiotensin-converting enzyme-2 Aspartate transaminase AST Brooklyn center Combination conducted Coronavirus-2 COVID-19 COVID-19 patients criterion Critical care diarrhea expressed Gastrointestinal Gastrointestinal symptom gastrointestinal tract hospital Hospital admission Hospital stay identify In-hospital Infection intensive care liver Liver function test liver parenchyma liver transaminase manifestation Mild Mortality nausea North Odds ratio outcome outcomes Patient patients patients with COVID-19 predict Presence Prognosis Protective receptor remained Result retrospective SARS-CoV-2 SARS-COV-2 infection Symptom Symptoms transaminases vomiting was used worsened [DOI] 10.7759/cureus.14543 PMC 바로가기 [Article Type] Gastroenterology
The Status of Occupational Protection During COVID-19 Pandemic: Knowledge, Attitudes, and Practice of Healthcare Workers in Endoscopy Units, ChinaPublic Health Published on 2021-03-222022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, [키워드] analyzed approaches Attitudes benefit carried changed China Chinese conducted contributing to correlation COVID-19 COVID-19 pandemic cross-sectional digestive endoscopy female gastrointestinal symptoms gastrointestinal tract healthcare healthcare worker increased risk independent infection rate knowledge Kruskal-Wallis test Linear regression male management MOST National Nurse occupational occupational protection Patient Patient care performed physician platform positive positive attitude Practice protection Protective questionnaire SARS-CoV-2 SARS-COV-2 infection Spread status Structure virus worker [DOI] 10.3389/fpubh.2021.632608 PMC 바로가기 [Article Type] Public Health
Spiking dependence of SARS‐CoV‐2 pathogenicity on TMPRSS2Review Published on 2021-03-182022-10-04 Journal: Journal of medical virology [Category] SARS, 유전자 메커니즘, [키워드] Affect affected blocker Cell clinical trial coronavirus COVID‐19 COVID‐19 determine difference differential expression Differential gene expression discrepancy disease drug Entry mechanism enzyme enzyme activity ethnic group expressed expression Factor gastrointestinal tract group groups highlight host cell host protease TMPRSS2 host susceptibility humans implicated infections inhibitor investigated kidney outcome outcomes pathogenicity Prostate Region regulated reported respiratory tract SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 susceptibility therapeutic option TMPRSS2 TMPRSS2 blockers TMPRSS2 inhibitors TMPRSS2 protease Treatment viral entry viral spike protein [DOI] 10.1002/jmv.26911 PMC 바로가기 [Article Type] Review