Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre study자가면역 염증성 류마티스 질환 성인 환자 및 일반 인구에서 BNT162b2 mRNA COVID-19 백신의 면역원성과 안전성: 다기관 연구Observational Study Published on 2021-10-012022-09-12 Journal: Annals of the rheumatic diseases [Category] MERS, SARS, 임상, 진단, [키워드] adverse event Autoimmune binding antibody unit biological therapy BNT162b2 mRNA BNT162b2 mRNA vaccine Control control group COVID-19 COVID-19 pandemic COVID-19 vaccine death defined Disease activity Efficacy evaluated Factor General population Glucocorticoids herpes zoster IgG IgG antibody IgG level immunogenic immunogenicity Inflammatory Major majority Messenger RNA methotrexate Mild MMF mRNA multicentre Older age Patient patients postvaccination Protein reduced remained rheumatic disease rituximab S1/S2 safety profile SARS-CoV-2 spike seronegative Seropositivity significantly significantly lower symptomatic case Treatment two-dose regimen vaccination Vaccine vaccine dose were assessed were measured [DOI] 10.1136/annrheumdis-2021-220647 PMC 바로가기 [Article Type] Observational Study
TNFi is associated with positive outcome, but JAKi and rituximab are associated with negative outcome of SARS-CoV-2 infection in patients with RMDTNFi는 긍정적인 결과와 관련이 있지만 JAKi와 rituximab은 RMD 환자에서 SARS-CoV-2 감염의 부정적인 결과와 관련이 있습니다.Article Published on 2021-10-012022-09-12 Journal: RMD Open [Category] 진단, [키워드] 95% CI analysed antirheumatic agents association cardiovascular disease Chronic kidney disease chronic lung disease collected Course COVID-19 COVID-19 severity Cyclophosphamide disease Disease activity feature glucocorticoid Glucocorticoids hospitalised hypertension Immunosuppressant Inflammatory influence inhibitor Janus kinase Male sex methotrexate MTX multivariable Musculoskeletal ordinal logistic regression outcome Patient patients died positive psoriatic arthritis rheumatoid arthritis risk factor SARS-COV-2 infection severe COVID-19 severity of COVID-19 TNF Treatment Ventilated [DOI] 10.1136/rmdopen-2021-001896 PMC 바로가기 [Article Type] Article
Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study입원한 COVID-19 환자의 SARS-CoV-2 농도 역학 및 항체 반응에 대한 덱사메타손의 영향: 전향적 관찰 연구 결과Observational Study Published on 2021-10-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 임상, 진단, [키워드] acute respiratory syndrome analysed antibody Antibody Response comparable Concentration coronavirus Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 nucleic acid testing Dexamethasone disease severity dosage enrolled Glucocorticoids hospitalized COVID-19 hospitalized patient IgA IgG Immunoglobulin Impact inclusion criteria IQR median nucleic acid pandemic Patient patients hospitalized prospective observational study RECOVERY trial RT-PCR SARS-CoV-2 SARS-CoV-2 virus Seroconversion serum sample severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe coronavirus disease severe COVID-19 Standard of care symptom onset the antibody response treated Treatment upper respiratory tract URT Viral concentration. Viral load Virological virus virus clearance was measured were measured [DOI] 10.1016/j.cmi.2021.06.008 PMC 바로가기 [Article Type] Observational Study
Management of Patients With Glucocorticoid-Related Diseases and COVID-19글루코코르티코이드 관련 질환 및 COVID-19 환자 관리Review Published on 2021-09-142022-09-11 Journal: Frontiers in Endocrinology [Category] MERS, SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition administration Adrenal insufficiency adrenocortical carcinoma affecting angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anticancer binding Cancer caused circulating cleaved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTSB CTSL Cushing’s syndrome cushing’s syndrome cytokine Cytokine storm Endocrine enzyme expressed furin gastrointestinal tract genes encoding glucocorticoid Glucocorticoids group Health Health crisis host cell host cells hyperaldosteronism immune response Immunosuppressant immunosuppressants immunosuppressive in silico analysis Infection inhibitory effect kidney lung management mRNA expression outcome pandemic pathophysiological mechanism Patient Pituitary protease respiratory SARS-CoV-2 secreted Serine serine 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 susceptibility the cytokine storm the timing tissues TMPRSS2 transmembrane transmembrane protease serine 2 Tumor tumors [DOI] 10.3389/fendo.2021.705214 PMC 바로가기 [Article Type] Review
A survey to evaluate knowledge, perceptions and attitudes toward COVID-19 vaccinations among rheumatologists in GermanyObservational Research Published on 2021-09-082022-10-29 Journal: Rheumatology International [Category] COVID-19, [키워드] anonymously asked Clinical practice COVID-19 vaccination COVID-19 vaccines evaluate Germany Glucocorticoids had more handling Immunmodulatory drugs immunomodulatory immunomodulatory drug IMPROVE indicate Inflammatory Inflammatory rheumatic diseases knowledge majority medication men mRNA vaccine participant Patient patients physician recommendation reduce reducing reported rheumatic disease rheumatologist rheumatology rituximab Society Support the vaccine vaccination women [DOI] 10.1007/s00296-021-04986-1 PMC 바로가기 [Article Type] Observational Research
Incidence of COVID-19 Hospitalisation in Patients with Systemic Lupus Erythematosus: A Nationwide Cohort Study from DenmarkArticle Published on 2021-08-272022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI adjusted analysed case-control study cohort study Comorbidities COVID-19 Denmark Disease activity General population Glucocorticoid treatment Glucocorticoids hazard ratio hospitalisation hospitalisation with COVID-19 hospitalised Hydroxychloroquine hydroxychloroquine treatment immune functions incidence incidence of COVID-19 increased risk Infection investigated Lupus Patient person year SLE SLE patient SLE patients systemic systemic lupus erythematosus Treatment with COVID-19 [DOI] 10.3390/jcm10173842 PMC 바로가기 [Article Type] Article
Asthma and COVID-19: Emphasis on Adequate Asthma ControlReview Article Published on 2021-08-242022-10-31 Journal: Canadian Respiratory Journal [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Adequate Affect ARMS association Asthma asthmatic cause Cell-mediated immunity chronic airway inflammation Clinical course clinician Control coronavirus COVID-19 COVID-19 pandemic Dexamethasone disease Evidence explain glucocorticoid Glucocorticoids hospitalized COVID-19 patients humoral incidence increased risk independent risk factor infections Influenza virus Inhaled inhaled corticosteroid management morbidity and mortality Mortality parainfluenza virus pathogenesis of SARS-CoV-2 Pneumonia promote recent reduce respiratory virus SARS-CoV SARS-COV-2 infection severity significant decrease significantly subject subset susceptibility virus [DOI] 10.1155/2021/9621572 PMC 바로가기 [Article Type] Review Article
Favorable outcomes with reduced steroid use in juvenile dermatomyositisResearch Article Published on 2021-08-172024-09-02 Journal: Pediatric Rheumatology Online Journal [Category] 대상포진, [키워드] Biologic therapy Calcinosis Glucocorticoids juvenile dermatomyositis Pediatric rheumatology [DOI] 10.1186/s12969-021-00615-0 PMC 바로가기 [Article Type] Research Article
Leflunomide plus low-dose prednisone in patients with progressive IgA nephropathy: a multicenter, prospective, randomized, open-labeled, and controlled trialarticle Published on 2021-08-152024-09-02 Journal: Renal failure [Category] 대상포진, [키워드] Disease progression Glucocorticoids IgA nephropathy leflunomide Proteinuria [DOI] 10.1080/0886022X.2021.1963775 PMC 바로가기 [Article Type] article
Long Noncoding RNAs as Emerging Regulators of COVID-19COVID-19의 새로운 조절자로서의 긴 비코딩 RNAReview Published on 2021-08-022022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] (Tocilizumab) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antiviral antiviral immune response antiviral immune responses antiviral role biological processe biological processes cellular changes in Clinical treatment coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 treatment death Dexamethasone disease drug Evidence expression glucocorticoid Glucocorticoids help Host host transcriptome immune dysfunction Immune escape immune responses incidence rate indicate Infection Inflammatory response inhibiting interferons involved lncRNA lncRNAs Long long noncoding RNA mechanisms monoclonal antibodies monoclonal antibody Occurrence pandemic pathology regulate Regulation regulator Research respiratory resulting RNA SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spread subsequent therapeutic thrombosis Tocilizumab Transcriptome Treatment type I interferon type I interferons up-regulate Viral viral gene viral genes viral infections viral replication virus infection virus infections [DOI] 10.3389/fimmu.2021.700184 PMC 바로가기 [Article Type] Review