Discovery and optimizing polycyclic pyridone compounds as anti-HBV agentsReview Published on 2020-09-012023-06-11 Journal: Expert opinion on therapeutic patents [Category] B형 간염, [키워드] drug design HBV inhibitors High-throughput screening hit-to-lead optimization Medicinal chemistry Polycyclic pyridone scaffold hopping. [DOI] 10.1080/13543776.2020.1801641 [Article Type] Review
SARS-CoV-2 RNA Extraction Using Magnetic Beads for Rapid Large-Scale Testing by RT-qPCR and RT-LAMPArticle Published on 2020-08-072022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] 96-well plate acute respiratory syndrome automated bead coronavirus COVID-19 Detection sensitivity diagnostic diagnostics E gene extraction fluorescent High-throughput screening Infection isothermal amplification Laboratory Large-scale testing magnetic bead magnetic bead RNA purification N gene pandemic Patient performed pharyngeal platform primer protocol quantitative PCR Rapid reagent reverse transcription RNA extraction RNA extraction kit RNA virus RT-LAMP RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA specificity swabs Testing variety Viral RNA [DOI] 10.3390/v12080863 PMC 바로가기 [Article Type] Article
An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screenArticle Published on 2020-08-042023-06-08 Journal: Proceedings of the National Academy of Sciences of [Category] Fulltext, 신종인플루엔자, [키워드] Fluorescence polarization hemagglutinin inhibitor High-throughput screening Influenza virus X-ray crystallography [DOI] 10.1073/pnas.2006893117 PMC 바로가기
Molecular malaria surveillance using a novel protocol for extraction and analysis of nucleic acids retained on used rapid diagnostic tests사용된 신속 진단 테스트에 남아 있는 핵산의 추출 및 분석을 위한 새로운 프로토콜을 이용한 분자 말라리아 감시Article Published on 2020-07-232024-08-11 Journal: Burma Med J [Category] 말라리아, [키워드] Diagnostic markers Diseases High-throughput screening Infectious diseases malaria [DOI] 10.1038/s41598-020-69268-5 PMC 바로가기 [Article Type] Article
Development of novel anti-malarial from structurally diverse library of molecules, targeting plant-like CDPK1, a multistage growth regulator of P. falciparumArticle Published on 2020-05-292024-08-28 Journal: Biochemical Journal [Category] 말라리아, [키워드] High-throughput screening kinases. Plasmodium falciparum
Detection of avian influenza virus: a comparative study of the in silico and in vitro performances of current RT-qPCR assaysArticle Published on 2020-05-212023-05-31 Journal: Scientific Reports [Category] Fulltext, 조류인플루엔자, [키워드] Assay systems High-throughput screening Microbiology techniques [DOI] 10.1038/s41598-020-64003-6 PMC 바로가기 [Article Type] Article
Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2Article Published on 2020-05-062022-10-04 Journal: Journal of Human Genetics [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] addition allele frequency B-cell response Bioinformatic calculated CD4 CD8 Coverage COVID-19 pandemic Deleterious develop epitope high affinity High-throughput screening HLA HLA class I HLA molecules homology host immune responses immune immune system Immunogenetics induce information Japanese membrane nonstructural protein Novel coronavirus Nucleocapsid proteins other coronaviruses peptide epitope populations predicted Prevent Region SARS-CoV SARS-CoV-2 sequence significantly T cell epitope T-cell T-cell responses the SARS-CoV-2 Vaccine virus [DOI] 10.1038/s10038-020-0771-5 PMC 바로가기 [Article Type] Article
Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria해양 천연물의 스크리닝을 통한 트리파노소마티드 및 말라리아에 대한 새로운 약물 후보 물질 탐색Review Published on 2020-03-312024-08-11 Journal: Marine Drugs [Category] 말라리아, [키워드] Chloroquine derivatives High-throughput screening malaria marine pharmacology neglected tropical diseases phenotypic screening target-based screening Trypanosomatids [DOI] 10.3390/md18040187 PMC 바로가기 [Article Type] Review
Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell linesArticle Published on 2020-03-132023-08-30 Journal: Nature Communications [Category] E형 간염, [키워드] High-throughput screening metabolic engineering metabolic pathways Stem-cell differentiation [DOI] 10.1038/s41467-020-15058-6 PMC 바로가기 [Article Type] Article
Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages강력한 지속적인 시험관 내 Plasmodium cynomolgi 적혈구 단계 배양Article Published on 2019-08-122024-08-11 Journal: Nature Communications [Category] 말라리아, [키워드] High-throughput screening malaria Model protists [DOI] 10.1038/s41467-019-11332-4 PMC 바로가기 [Article Type] Article