highly pathogenic

[키워드] activate activated Activation of SARS-2-S adaptive mechanism adaptive mechanisms adjusted airway adaptation airways alternative route authentic virus replication Author cathepsin L cathepsin L pathway cathepsin-rich cells caused cell tropism common cold common cold coronavirus contrary contributed coronavirus coronavirus spike protein coronavirus virulence coronaviruses SARS-CoV COVID-19 pandemic Critical D614 variant D614G mutation deletion mutants effective ENhance explain extended loop length feature furin furin recognition motif G614 variant HCoV HCoV-229E high transmissibility of SARS-CoV-2 highly pathogenic human airway human airways human coronaviruses human host human respiratory tract increase indicate intrinsic temperature preference loop deletion mutant loop deletion mutants lower airways mechanism MERS MERS-CoV mild common cold other coronavirus other coronaviruses pathogenic HCoV-229E virus pathology predominant processing produced promote property protease protease condition protease conditions Proteases Protein pseudoviruses pseudoviruses of SARS-CoV-2 replaced Replication respiratory respiratory tract S protein S protein stability S proteins S1/S2 cleavage loop SARS-2-S SARS-2-S-driven entry SARS-CoV SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 spike SARS-CoV-2 stability severe pneumonia significantly increased spike activator spike property Spike protein Spike proteins spike stability spike-D614 spike-G614 variant Spread surface protease surface proteases temperature temperature and protease conditions the S protein the SARS-CoV-2 the spike protein TMPRSS13 TMPRSS13 protease TMPRSS2 transmissibility of SARS-CoV-2 upper airways upper or lower airways Usage Viral viral spike protein virulent coronavirus virulent coronaviruses virus virus entry virus preference virus spread virus transmission Zoonotic introduction
[DOI] 10.1371/journal.ppat.1009500 PMC 바로가기 [Article Type] Research Article