The Vaginal Virome—Balancing Female Genital Tract Bacteriome, Mucosal Immunity, and Sexual and Reproductive Health Outcomes?Review Published on 2020-07-302022-10-28 Journal: Viruses [Category] COVID-19, [키워드] adverse birth outcomes archaea association Bacteria Bacterial bacteriome component contribute current described disease ecosystem female genital tract fungi Gut Health host immunity Immunity include limitation literature Microbiome microbiota mucosal outcomes reproductive Research risk sexual tract Vaginal vaginal virome virus viruses while [DOI] 10.3390/v12080832 PMC 바로가기 [Article Type] Review
Epigenetic Regulator miRNA Pattern Differences Among SARS-CoV, SARS-CoV-2, and SARS-CoV-2 World-Wide Isolates Delineated the Mystery Behind the Epic Pathogenicity and Distinct Clinical Characteristics of Pandemic COVID-19SARS-CoV, SARS-CoV-2 및 SARS-CoV-2 전 세계 분리주 사이의 후성유전 조절자 miRNA 패턴 차이로 팬데믹 COVID-19의 서사적 병원성과 독특한 임상적 특징 뒤에 숨겨진 미스터리Genetics Published on 2020-07-102022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] alleviate anomalies Anomaly antiviral miRNAs autophagy binding breathing complications cardiovascular diseases cellular miRNA cellular pathway clinical Comorbidities Complication computational approach Computational approaches country COVID-19 COVID-19 patients death death rates diabetes difference disease effective epigenetic modulator epigenetic regulator experiments Factors functional Gene Expression Host host antiviral miRNA host genes host immunity host miRNA host's miRNAs human cell IFN-I IFN-I signaling immune regulation immune-escape mechanism immune-signaling pathways implication isolate latency lead Microarray miRNA miRNA clusters miRNA-mediated interaction miRNA-microRNA miRNAs mode modulate molecular mechanism Neutralizing normalized over representation analysis Pathogenesis Pathways patients with comorbidity pattern predict predicted profile regulator RNA therapeutics RNA-Seq SARS virus SARS viruses SARS-CoV SARS-CoV and SARS-CoV-2 viral miRNAs SARS-CoV and SARS-CoV-2 viruses SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 miRNAs SARS-CoV-2 pathogenesis SARS-CoV-2 viral SARS-CoV-2 virus SARS-infected human cell microarray signaling pathways Support symptoms of COVID-19 target targets the SARS-CoV-2 Viral viral miRNA viral miRNAs viral pathogenesis viruses [DOI] 10.3389/fgene.2020.00765 PMC 바로가기 [Article Type] Genetics
Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme 3CL pro targeting repurposed drug candidatesResearch Published on 2020-07-092022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] 3CL pro acute respiratory syndrome African analysed anti-malarial drug Anti-viral bat-CoV Clustal Omega collected Complete Compound cysteine protease database drug candidate enzyme fatality Genetic Genome genomic sequence GISAID high mutation rate host genome host immunity identity implication in silico analysis in silico approaches in-depth analysis individual infection rate inhibitor initiative Interaction isolate Local Multiple mutagenic mutations occurred pandemic Pandemics pangolin-CoV pathogen pathogenicity pharmacological populations provide recurrent mutation reference genome regulate reported Repurposed drug Result RNA SARS Coronavirus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 infected patients SARS-CoV2 sequence South South America the SARS-CoV-2 unique viral genome viral pathogenicity viral replication viral sequence was collected was used Wuhan [DOI] 10.1186/s12967-020-02448-z PMC 바로가기 [Article Type] Research
Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structureSARS-CoV-2의 RNA 의존성 RNA 중합효소의 새로운 돌연변이 식별 및 단백질 구조에 미치는 영향Biochemistry Published on 2020-07-032022-08-13 Journal: PeerJ [Category] Biochemistry, COVID-19, [키워드] (RdRp Alter alteration Analysis antigenic antivirals COVID-19 pandemic develop drug resistance duplication effective evade functional consequence functional consequences Genome Health high mutation rate highlighting host immunity identification identify implication Indian geographical area interfere isolate Mutation mutation rate Nsp12 Occurrence pharmacological agents Protein RdRP RdRp mutation RdRp mutations RdRp protein RdRp sequence RdRp sequences RNA synthesis RNA virus RNA-dependent RNA polymerase RNA-dependent RNA polymerases (RdRp) SARS-CoV-2 SARS-CoV-2 isolate secondary structure secondary structure prediction analysis sequence Seven shifting stability the SARS-CoV-2 Variability Variation Viral viral evolution viral genome Viral RNA Viral RNA-dependent RNA polymerases virus viruses [DOI] 10.7717/peerj.9492 PMC 바로가기 [Article Type] Biochemistry
Systemically comparing host immunity between survived and deceased COVID-19 patientsCorrespondence Published on 2020-06-152022-11-01 Journal: Cellular and Molecular Immunology [Category] COVID-19, MERS, SARS, [키워드] COVID-19 patient Deceased host immunity Prognostic markers survived viral infection [DOI] 10.1038/s41423-020-0483-y PMC 바로가기 [Article Type] Correspondence
Novel Immunoglobulin Domain Proteins Provide Insights into Evolution and Pathogenesis of SARS-CoV-2-Related VirusesResearch Article Published on 2020-05-292022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Alpha Analysis arising attenuate beta-coronavirus beta-CoV Combination comparable Complete coronavirus coronavirus disease CoV COVID-19 COVID-19 pandemic determinant domain Evolution evolutionary arms race Factor Genome Genomic analysis genomic region Health Host Host immune response host immunity hosts identify immune immune evasion immune pressure Immunoglobulin individual insight macro modulate MOST novel Novel coronavirus ORF1a ORF8 outbreak Pathogenesis pathogenicity predicted Protein Proteins Receptor binding domain Region SARS SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 protein SARS-like coronavirus scrutiny sequence severity Structural analysis the Spike Transmission unique virus Virus-host interactions viruses widespread [DOI] 10.1128/mBio.00760-20 PMC 바로가기 [Article Type] Research Article
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variantResearch Published on 2020-04-222022-10-06 Journal: Journal of Translational Medicine [Category] SARS, 진단, [키워드] Amino acid analyzed Asian binding characterized Clustal Omega COVID-19 develop drug resistance drugs targeting England enzyme Europe European Factors GenBank database Genome genomic sequence GISAID database high mutation rate host immunity hosts hydrophobic include investigated Italy lombardy median mortality rates mutagenic mutated Mutation mutation rate North North America nucleic acids pandemic Patient Phenotypes Pneumonia Point mutation polymerase predicted RdRP RdRp gene recognize recurrent mutation replicate respiratory responsible Result RNA coronavirus RNA polymerase RNA virus RNA-dependent-RNA-polymerase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 RdRp SARS-CoV-2 reference genome SARS-CoV-2 RNA silent statistical significance strain Treatment Variability variant viral evolution Viral mutagenesis virus was obtained was performed were used [DOI] 10.1186/s12967-020-02344-6 PMC 바로가기 [Article Type] Research
Associations between immune-suppressive and stimulating drugs and novel COVID-19—a systematic review of current evidenceReview Published on 2020-03-272022-10-31 Journal: ecancermedicalscience [Category] COVID-19, [키워드] acute respiratory syndrome adverse events anti-CD20 auto-immune disease blockade blockers Cancer Chemotherapy coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Cytokines Cytotoxic chemotherapy drug drugs Effect elevated Evidence higher risk host immunity IL-1 IL-6 IL-6 inhibitor immune modulation Immune suppression Impact In vitro studies induce inhibitor inhibitors Jak JAK-STAT pathway Janus kinase Kinase inhibitor less low-dose methotrexate modulation Necrosis non-steroidal anti-inflammatory drug NSAIDS OVID Patient patients patients with COVID-19 Prednisolone pro-inflammatory cytokine pulmonary complications respiratory diseases Result secretion severity shown Steroids systematic review target TNFα treated Treatment [DOI] 10.3332/ecancer.2020.1022 PMC 바로가기 [Article Type] Review
Influence of Sorafenib on Host Immunity in Patients with Liver Cirrhosis With Advanced Hepatocellular Carcinoma Stratified by EtiologyArticle Published on 2019-04-012023-06-19 Journal: Anticancer research [Category] B형 간염, [키워드] etiology Hepatocellular carcinoma host immunity Liver cirrhosis sorafenib th1/th2 balance [DOI] 10.21873/anticanres.13333
Three types of preS1 start codon deletion variants in the natural course of chronic hepatitis B infectionArticle Published on 2018-07-012023-06-19 Journal: Journal of gastroenterology and hepatology [Category] B형 간염, [키워드] Chronic Hepatitis B Deletion hepatitis B surface antigen Hepatitis B virus host immunity Liver cirrhosis preS variant. [DOI] 10.1111/jgh.14069