A Seroprevalence Study of Anti-SARS-CoV-2 Antibodies in Patients with Inflammatory Bowel Disease during the Second Wave of the COVID-19 Pandemic in Italy이탈리아에서 COVID-19 팬데믹의 2차 파동 동안 염증성 장 질환 환자에서 Anti-SARS-CoV-2 항체의 혈청유병성 연구Article Published on 2021-10-012022-09-12 Journal: Medicina [Category] MERS, SARS, 진단, [키워드] aims analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody association Characteristics close contact Colitis collected contact with control group Corticosteroid Corticosteroids COVID-19 Crohn’s disease determine determined by enrolled extension greater groups healthcare worker IBD Inflammatory bowel disease Italy likelihood Mask material mesalazine not significantly different Patient patients phenotype Prevalence receiving risk risk factor SARS-CoV-2 SARS-CoV-2 positive individual SARS-CoV-2 positive individuals second Seropositivity Seroprevalence serum shown significantly therapy Treatment ulcerative colitis was collected Wave [DOI] 10.3390/medicina57101048 PMC 바로가기 [Article Type] Article
Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD인플릭시맙은 IBD 환자에서 BNT162b2 및 ChAdOx1 nCoV-19 SARS-CoV-2 백신에 대한 면역원성 약화와 관련이 있습니다.Article Published on 2021-10-012022-09-12 Journal: Gut [Category] MERS, SARS, 진단, [키워드] 95% CI age anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody antibody concentration Antibody concentrations Antibody Response Autoimmune Autoimmune disease BNT162b2 BNT162b2 vaccine bowel ChAdOx1 ChAdOx1 nCoV-19 CLARITY Cohort Concentration concentrations COVID-19 cut-off defined Delayed disease dose Effectiveness Elecsy Evidence Fold change geometric mean IBD Immunity immunomodulator Infection Inflammatory Inflammatory bowel disease Inflammatory diseases infliximab investigated monoclonal antibody Multivariable models of BNT162b2 outcome Patient patients patients treated Primary outcome SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines second dose secondary Seroconversion seroconversion rate serological response single dose smoking TNF treated vaccination Vaccine Vaccines vedolizumab [DOI] 10.1136/gutjnl-2021-324789 PMC 바로가기 [Article Type] Article
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cellsArticle Published on 2021-09-232022-10-04 Journal: Cell Death & Disease [Category] 신약개발, [키워드] Activation anti-TNF Apoptosis autoinflammatory disease biochemical biopsy canonical CASP8 caspase caspase-8 cell death Cell death and immune response contribute Critical Crohn's disease Crohn’s disease cytokine death dependence driven by driver epithelial Ex vivo feature Genetic Gut Host IBD IEC IFN-γ immunopathology independent induce Inflammatory bowel disease inhibitor interferons intestinal epithelial cell Intestinal Organoids involved JAK inhibitor kill killing kinase loss-of-function mechanisms MLKL mucosal necroptosis Organoid pathway required retained sustained synergistic T cells therapeutic efficacy TNF-α TNFR1 Tumour-necrosis factors ZBP1 [DOI] 10.1038/s41419-021-04151-3 PMC 바로가기 [Article Type] Article
Following Pediatric and Adult IBD Patients through the COVID-19 Pandemic: Changes in Psychosocial Burden and Perception of Infection Risk and Harm over TimeArticle Published on 2021-09-132022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Adults age association burden calculated Cancelled change comparable Complication condition COVID-19 Crohn’s disease Disease activity elderly female female gender Gender group IBD immune response Infection Inflammatory bowel disease investigated large cohort Logistic Logistic regression analysis male mother outcome parent Patient patients Perceived Perceived risk Perception physical activity positive Psychosocial Psychosocial stress Quality of life questionnaire risk risk of infection SARS-CoV-2 SARS-CoV-2 antibody Sleep disturbance stratified Stress time ulcerative colitis was performed [DOI] 10.3390/jcm10184124 PMC 바로가기 [Article Type] Article
Common contributing factors to COVID-19 and inflammatory bowel diseaseCOVID-19 Pandemic: Health impact and Novel research Published on 2021-08-312022-10-04 Journal: Toxicology Reports [Category] 바이오마커, 유전자 메커니즘, [키워드] Abstract acute respiratory syndrome approach biologic candidate Chronic diseases common Complication contribute Contributing factors coronavirus coronavirus disease COVID-19 Crohn’s disease Crohn’s disease demonstrated disease Diseases dysfunctional immune system event Factor Factors Government Health IBD identify immune dysfunction immune function immune response immune system Immune system dysfunction Impact impacted impair Infection Inflammatory bowel disease initial LRDI Multiple overlap overlapping pandemic psychosocial stressors representing Result SARS-CoV SARS-CoV-2 Severe acute respiratory syndrome starting point Stressor toxic substance Treatment ulcerative colitis was used with COVID-19 [DOI] 10.1016/j.toxrep.2021.08.007 PMC 바로가기 [Article Type] COVID-19 Pandemic: Health impact and Novel research
Risk, Course, and Effect of SARS-CoV-2 Infection in Children and Adults with Chronic Inflammatory Bowel DiseasesReview Published on 2021-08-302022-10-31 Journal: Children [Category] COVID-19, [키워드] ACE2 Admission adverse outcomes Angiotensin converting enzyme-2 anti-TNF Bacterial infection benefit biologic Biologic drugs characteristic chronic Clinical characteristics contrary Corticosteroids COVID-19 COVID-19 infection Crohn’s disease Cytokine storm death disease disease course drug drugs Effect epidemiological data excluded facilitate form IBD ICU immune system immunomodulators immunosuppressive therapies Immunosuppressive treatment increased risk Infection Inflammatory bowel disease infliximab Influenza intensive care Patient patients Pneumonia receptor reduce mortality replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 shown suppress susceptibility Tocilizumab Topic treated ulcerative colitis [DOI] 10.3390/children8090753 PMC 바로가기 [Article Type] Review
Social Distancing during COVID-19 Pandemic among Inflammatory Bowel Disease PatientsArticle Published on 2021-08-202022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] anti-SARS-CoV-2 antibody antibody collected Concentration coronavirus disease correlation COVID-19 demographic data effective Effectiveness ELISA group hospital IBD IgG Inflammatory bowel disease introduced Isolation lowest maintaining pandemic Patient patients reducing Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 virus SARS-CoV2 social distancing social isolation Spread the patient were measured [DOI] 10.3390/jcm10163689 PMC 바로가기 [Article Type] Article
A machine learning approach identifies 5-ASA and ulcerative colitis as being linked with higher COVID-19 mortality in patients with IBDArticle Published on 2021-08-132022-10-04 Journal: Scientific Reports [Category] MERS, 유전자 메커니즘, [키워드] Accuracy age analyses Analysis approach association available data Bacterial infection bowel Case report Characteristics chronic inflammation circumvent comprehensive analysis Computer science condition conditions covariate covariates COVID-19 COVID-19 mortality Crohn's disease Crohn’s disease database Deceased demographic factor detect disease Factor Features gastrointestinal tract Gender generate Generation Health higher risk Hospitalized IBD identify immunosuppressants infections Inference information International lack machine learning approach male management medication MONITOR Mortality number of comorbidity outcome outcomes Patient patient data patients predict Prognosis random reported Repository reveal severity smoking Treatment ulcerative colitis [DOI] 10.1038/s41598-021-95919-2 PMC 바로가기 [Article Type] Article
Psychological reaction to Covid-19 of Italian patients with IBDResearch Article Published on 2021-08-062022-10-28 Journal: BMC Psychology [Category] COVID-19, MERS, SARS, [키워드] Affect analyzed ANOVA association clinical information contracting the virus COVID-19 disease disease management Effect eligible groups hospital IBD independent Infection Inflammatory bowel disease Italian Italian patient Italian patients majority management medium National Novel coronavirus Patient patient engagement Psychological Psychological outcomes psychological reaction questionnaire reported Responder Result risk Self-efficacy Self-management Stress supplementary material Support variance was selected [DOI] 10.1186/s40359-021-00622-6 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Vaccination in IBD: Past Lessons, Current Evidence, and Future ChallengesIBD의 SARS-CoV-2 예방 접종: 과거 교훈, 현재 증거 및 미래 과제Review Published on 2021-08-022022-09-11 Journal: Journal of Crohn's & colitis [Category] SARS, 변종, [키워드] cellular challenge Community complications of COVID-19 COVID-19 current Effectiveness Evidence Future high risk humoral IBD identify immune response immune responses immunogenicity immunosuppressive immunosuppressive therapy in some individual Infection Inflammatory bowel disease inflammatory bowel diseases knowledge lAbel off-label pandemic Patient patients SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines therapy translated trials vaccination Vaccination strategies Vaccination strategy Vaccine Vaccines variants were excluded [DOI] 10.1093/ecco-jcc/jjab046 PMC 바로가기 [Article Type] Review