Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland면역 저하 환자, 아일랜드에서 SARS-CoV-2 바이러스의 게놈 진화Research Letter Published on 2021-09-012022-09-10 Journal: Emerging Infectious Diseases [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 2019 novel coronavirus disease acute respiratory syndrome B-cell therapy coronavirus coronavirus disease COVID-19 Evolution examined Genetic variation genomic genomic sequencing Immunocompromised Immunocompromised patient Immunocompromised patients Infection Ireland lead Mutation new virus Prolonged Prolonged infection respiratory respiratory infections SARS-CoV-2 Sequencing severe acute respiratory syndrome coronavirus 2 superinfection variants virus Virus evolution viruses zoonoses [DOI] 10.3201/eid2709.211159 PMC 바로가기 [Article Type] Research Letter
Mycotic infections – mucormycosis and oral candidiasis associated with Covid-19: a significant and challenging associationResearch Article Published on 2021-08-262022-10-30 Journal: Journal of Oral Microbiology [Category] COVID-19, [키워드] Adults affecting Antibiotics article association biofilm black Black fungus C. albican Candida albican caused Clinical sign COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients dental Diagnosis Factor fungal healthy ICU Immunocompromised patient lesion lesions management material mechanical ventilation morbidity and mortality Mucormycosis mycotic infection oral candidiasis pandemic Practitioner receive reduce reported resulting risk SARS-CoV-2 Secondary infection spore Symptom Therapeutic approach white fungus [DOI] 10.1080/20002297.2021.1967699 PMC 바로가기 [Article Type] Research Article
Emergence of Multiple SARS-CoV-2 Antibody Escape Variants in an Immunocompromised Host Undergoing Convalescent Plasma Treatment회복기 혈장 치료를 받는 면역 저하된 숙주에서 여러 SARS-CoV-2 항체 탈출 변이체의 출현Research Article Published on 2021-08-252022-09-10 Journal: mSphere [Category] MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta) accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha anti-SARS-CoV-2 antibody B.1.1.7 B.1.351 B.1.617.2 Beta compromised immune status convalescent plasma Convalescent plasma therapy convalescent plasma treatment coronavirus COVID-19 pandemic Deletion deletions disease severity domain E484K Efficacy emergence escape Evidence evidence of Evolution FIVE genomic hosts hypothese hypotheses identify IgG immune escape mutants Immunocompromised Immunocompromised patient Immunocompromised patients Immunosuppressed Immunosuppression in vitro lentiviral Lineage lineages measure microevolution Multiple mutant mutants Mutation mutations N-terminal domain neutralization Neutralizing antibodies neutralizing antibody NTD observation over P.1 Patient Population Prolonged infection pseudovirus RBD RBD mutation RBD mutations RBD region Receptor-binding domain reduce reduced Region required respiratory S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variant SARS-CoV-2 variants selective pressure sequence serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein steroid Steroids Support susceptibility Swab the S protein therapy total Ig tracheal tracheal aspirate Transmissibility Transmission unique Vaccine variants variants of concern Viral viral evolution VoC VOCs [DOI] 10.1128/mSphere.00480-21 PMC 바로가기 [Article Type] Research Article
High-titre convalescent plasma therapy for an immunocompromised patient with systemic lupus erythematosus with protracted SARS-CoV-2 infection장기간의 SARS-CoV-2 감염을 동반한 전신성 홍반성 루푸스가 있는 면역저하 환자를 위한 고역가 회복기 혈장 요법Case Reports Published on 2021-08-252022-09-11 Journal: BMJ case reports [Category] SARS, 치료기술, [키워드] Administered anti-CD20 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Antimicrobial therapy Biological agents Bronchoalveolar lavage cell cultures Clinical improvement convalescent plasma Convalescent plasma therapy Corticosteroid COVID-19 COVID-19 pneumonia Dexamethasone High-dose hospital hypoxaemia Immunocompromised Immunocompromised patient lung opacities lupus erythematosus monoclonal antibody opportunistic infection opportunistic Infections PCR Pneumonia positive receiving Respiratory system reverse transcription PCR rituximab SARS-CoV-2 SARS-COV-2 infection symptom onset systemic lupus erythematosus Transcription treated Treatment virus replication with COVID-19 [DOI] 10.1136/bcr-2021-244853 PMC 바로가기 [Article Type] Case Reports
Comprehensive Characterization of COVID-19 Patients with Repeatedly Positive SARS-CoV-2 Tests Using a Large U.S. Electronic Health Record Database대규모 미국 전자 건강 기록 데이터베이스를 사용하여 SARS-CoV-2 검사에서 반복적으로 양성인 COVID-19 환자의 종합적인 특성화Research Article Published on 2021-08-182022-09-12 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission black characterization characterized Clinical data clinical manifestation clinical manifestations Comorbidities Comprehensive conditions consequence coronavirus coronavirus disease COVID-19 database demonstrated Diagnosis EHR Electronic health record estimate exhibited female followed by Genome sequencing genome sequencing data Health health record help Hospitalization Hospitalized ICU immune systems Immunocompromised patient intensive care intensive care unit lack limitations median age median interval Medical conditions Mild Molecular tests negative test no symptom obese obesity outcome overweight/obese Patient PCR test positive positive molecular test positive SARS-CoV-2 PCR Positive test Prevalence PT14 Record Reinfection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test SARS-CoV-2 tests separated severe acute respiratory syndrome Coronavirus smoking Surveillance Symptom symptom resolution Symptoms Test These data Viral load with COVID-19 [DOI] 10.1128/Spectrum.00327-21 PMC 바로가기 [Article Type] Research Article
Prolonged viral shedding of SARS-CoV-2 in two immunocompromised patients, a case report두 명의 면역 저하 환자에서 SARS-COV-2의 장기간 바이러스 흘림, 사례 보고서Case Reports Published on 2021-08-032022-09-01 Journal: BMC Infectious Diseases [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome Admission Analysis blood sample Blood samples Case report CD8+ T cell cellular Chain Reaction Clinical course clinical courses collected coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 courses COVID-19 Culture Dexamethasone during admission first positive flow cytometry full genome sequencing Genome sequencing Hospitalization Humoral immunity ICU immune marker immune markers Immunocompromised Immunocompromised host Immunocompromised patient Immunocompromised patients immunological infected with SARS-CoV-2 intensive care intensive care unit Isolation marker one patient Patient PCR test Plaque assay polymerase chain polymerase chain reaction Prolonged reactive real time Remdesivir respiratory respiratory symptoms reverse transcription reverse transcription polymerase chain reaction RT-PCR RT-PCR test SARS-CoV-2 SARS-CoV-2 IgG severe acute respiratory syndrome coronavirus 2 severe respiratory symptom severe respiratory symptoms supplementary material T cells Treatment undetectable Viral viral culture Viral load viral shedding virus Virus shedding without symptom [DOI] 10.1186/s12879-021-06429-5 PMC 바로가기 [Article Type] Case Reports
Robust Antibody and T Cell Responses to SARS-CoV-2 in Patients with Antibody Deficiency항체 결핍 환자에서 SARS-CoV-2에 대한 강력한 항체 및 T 세포 반응Article Published on 2021-08-012022-09-11 Journal: Journal of Clinical Immunology [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] adaptive Adaptive immune response antibody Antibody deficiency Antibody Response Antibody responses candidate vaccine cellular immunity characterized Clinical course Cohort common variable immunodeficiency common variable immunodeficiency. Control controls convalescent COVID-19 deficiency demonstrated described Diagnosis donors evaluated healthy humoral Humoral immunity immune immune deficiency immune response Immunity Immunocompromised patient Immunocompromised patients immunodeficiency in some Inborn errors increased risk infected with SARS-CoV-2 Jackson Lancet Long Longevity NAT no significant difference nucleocapsid onset of symptoms Patient patients Pediatric patient Pediatric patients Prolonged infection response robust SARS-CoV-2 significant difference Spike protein Spike proteins structural protein structural proteins T cell T cell response T cell responses the timing Variability were assessed while [DOI] 10.1007/s10875-021-01046-y PMC 바로가기 [Article Type] Article
Long-Term Evolution of SARS-CoV-2 in an Immunocompromised Patient with Non-Hodgkin Lymphoma비호지킨 림프종을 가진 면역저하 환자에서 SARS-CoV-2의 장기적 진화Research Article Published on 2021-07-282022-09-10 Journal: mSphere [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] A222V accelerated accumulated accumulation adaptive Administered alterations Amino acid amino acid change Antigen Community Convalescent plasma therapy convergent evolution COVID-19 Deletion epidemiological evaluate Evolution Evolution of SARS-CoV-2 Genome Genome sequencing identify immune evasion Immune status Immunocompromised Immunocompromised host immunocompromised individual immunocompromised individuals Immunocompromised patient Immunocompromised patients immunosuppressive immunosuppressive therapy infected individuals Infection long-term infection mitigate MONITOR Mutation mutations Non-Hodgkin Lymphoma occurred pandemic virus pathway Patient polymorphism Protein recent reported risk SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 infections scenario shown single-nucleotide Single-nucleotide polymorphisms SNPs spike Spike protein Support survival the SARS-CoV-2 therapy Transmission Trigger variant variants variants of concern Viral Viral genome sequencing virus virus spike protein was performed [DOI] 10.1128/mSphere.00244-21 PMC 바로가기 [Article Type] Research Article
Administration of COVID-19 vaccines in immunocompromised patientsArticle Published on 2021-07-282022-11-01 Journal: International immunopharmacology [Category] COVID-19, MERS, SARS, [키워드] anti-cancer therapies Autoimmune disease autoimmune disorder Cancer clinical trials condition conducted Consensus COVID-19 COVID-19 vaccine COVID-19 vaccines Critical Efficacy exclusion groups help hematologic malignancies IBD immune response immune system immunization Immunocompromised patient immunological immunosuppressive agent indicated Inflammatory bowel disease knowledge medications multiple sclerosis Patient patients Patients with cancer Population provided receiving solid organ transplantation Stem cell transplantation transplantation trials vaccination Vaccine viruses [DOI] 10.1016/j.intimp.2021.108021 PMC 바로가기 [Article Type] Article
A Possible Role of Remdesivir and Plasma Therapy in the Selective Sweep and Emergence of New SARS-CoV-2 VariantsReview Published on 2021-07-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Administered anti-spike antibodies Brazil changes characterized clinical trial convalescent plasma coronavirus COVID-19 COVID-19 pandemic elicited emergence Europe favor Genetic Hypothesis Immune escape Immunocompromised patient include Infection Lineage MONITOR monoclonal antibody multiple mutation mutants Mutation neutralizing antibody New new SARS-CoV-2 Occurrence Patient physician plasma therapy promoter recent Remdesivir replaced role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 variants South Africa Spread Support the patient therapy treat Vaccine immunization variant variants viral mutation viral spike protein whole-genome sequencing [DOI] 10.3390/jcm10153276 PMC 바로가기 [Article Type] Review