mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants순진하고 COVID-19에서 회복된 개인의 mRNA 백신 접종은 SARS-CoV-2 변이체를 인식하는 강력한 기억 B 세포를 이끌어냅니다Article Published on 2021-12-142022-09-11 Journal: Immunity [Category] Fulltext, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition affinity Affinity maturation Analysis antibody B-cell B-cell memory B.1.351 B.1.617.2 Beta BNT162b2 BNT162b2 vaccine Cell Cohort coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture defined elicit Germinal center high affinity immune protection immunoglobulins individual MBC MBCs memory memory B memory B cell memory response mRNA vaccination naïve individuals naïve vaccinees neutralization Neutralizing neutralizing antibody plasma Plasma cells RBD recall recognize respiratory respond response responses retained SARS-CoV-2 SARS-CoV-2 variant serum serum immunoglobulins severe acute respiratory syndrome Coronavirus Somatic hypermutation vaccination vaccinee variants variants of concern VOCs [DOI] 10.1016/j.immuni.2021.09.011 PMC 바로가기 [Article Type] Article
Epidemiological study in a small rural area of Veneto (Italian region) during Sars-Cov-2 PandemiaSARS-COV-2 Pandemia 동안 베네토 (이탈리아 지역)의 작은 농촌 지역에서의 역학 연구Article Published on 2021-12-012022-09-01 Journal: Scientific Reports [Category] SARS, 진단, [키워드] acid acute respiratory syndrome affected asymptomatic form categories category circulating Community Complication Contact contact with Contagion coronavirus demonstrated Disease prevention distance East effective Epidemiological study Epidemiology extreme family members Fever General population IgG IgM Immunity immunoglobulins Infection Isolation Italian Italy less lockdown NAAT Nasopharyngeal swab North nucleic acid amplification testing pathogen Patient care Population screening positive Prevalence public health random Random sample respiratory SARS-CoV-2 Severe acute respiratory syndrome severe symptom shown spring subject subjects Symptom symptomatic tested Testing Veneto virus was performed [DOI] 10.1038/s41598-021-02654-9 PMC 바로가기 [Article Type] Article
Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination기도 항체는 COVID-19 중증도에 따라 나타나고 빠르게 감소하지만 SARS-CoV-2 백신 접종 후 다시 나타남Research Article Published on 2021-11-222022-09-12 Journal: JCI Insight [Category] MERS, SARS, 진단, [키워드] acute disease Adaptive immunity addition airway airways antibodies antibody Antibody Response Antibody responses asymptomatic infection boost clinically Cohort convalescence correlated COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patients COVID-19 severity declined disease elevated evaluated fatal disease highlighting IgA IgG IgG level immune response immune responses immunoglobulins immunology increase in individual individuals infected individual infected individuals Innate immunity mucosal naïve individuals neutralize Prevent prime prime and boost representing required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination significantly subset the antibody response understanding vaccination Vaccinations viral spread virus [DOI] 10.1172/jci.insight.151463 PMC 바로가기 [Article Type] Research Article
Exceptionally potent human monoclonal antibodies are effective for prophylaxis and treatment of tetanus in mice특히 강력한 인간 단클론 항체는 쥐에서 파상풍의 예방 및 치료에 효과적이다.Article Published on 2021-11-152024-08-18 Journal: The World Allergy Organization Journal [Category] 파상풍, [키워드] immunoglobulins neuroscience Therapeutics Toxins/drugs/xenobiotics.
Six-month outcomes and effect of pulmonary rehabilitation among patients hospitalized with COVID-19: a retrospective cohort studyResearch Article Published on 2021-11-122022-10-28 Journal: Annals of Medicine [Category] COVID-19, SARS, [키워드] adjusted affecting age Analysis assigned Biomarker blood chemistry CD4+ T cell changed changes in China confounders control group covariate COVID-19 COVID-19 hospitalization COVID-19 patient disease Effect evaluated exercise Exercise capacity FIVE Follow-up greater groups Health IgM Immunity immunoglobulins immunology increase in investigated maintain majority male outcome Patient patients patients hospitalized performed physical Primary outcome promote pulmonary rehabilitation ranged rehabilitation Respiration Result retrospective cohort retrospective cohort study SARS-CoV-2 SARS-CoV-2 IgG secondary significantly Standard deviation T-lymphocyte variable [DOI] 10.1080/07853890.2021.2001043 PMC 바로가기 [Article Type] Research Article
Serum IgG4 level predicts COVID-19 related mortality혈청 IgG4 수준은 COVID-19 관련 사망률을 예측합니다Article Published on 2021-11-012022-09-12 Journal: European journal of internal medicine [Category] MERS, SARS, 진단, [키워드] Abstract COVID-19 COVID-19 related mortality IgG4 immunoglobulins predict SARS-CoV-2 Subclasses [DOI] 10.1016/j.ejim.2021.09.012 PMC 바로가기 [Article Type] Article
Seasonal coronavirus–specific B cells with limited SARS-CoV-2 cross-reactivity dominate the IgG response in severe COVID-19Research Article Published on 2021-11-012023-06-14 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, [키워드] immunoglobulins immunology Imprinting Virology [DOI] 10.1172/JCI150613 PMC 바로가기 [Article Type] Research Article
Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessment for antibody-based Covid-19 therapeutics and vaccinesSARS-CoV-2 스파이크 단백질 중화 항체 탈출: 항체 기반 Covid-19 치료제 및 백신에 대한 위험 평가Review Published on 2021-11-012022-09-11 Journal: Reviews in Medical Virology [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Affect African antibody B.1.1.7 B.1.351 bamlanivimab BNT162b2 Casirivimab circulating clades Combination convalescent convalescent plasma convergent evolution COVID-19 Deletion E484K Efficacy etesevimab focus hotspot Imdevimab immune Immune escape immunoglobulins inventory L452R LY-CoV555 LyCoV016 monoclonal antibodies mRNA mRNA-1273 Mutation mutations N439K N501Y neutralising neutralising antibody P.1 P.2 Phylogenetic polyclonal polyclonal immunoglobulins. Protein RBD Receptor binding domain REGN10933 REGN10987 Risk assessment S477N SARS-CoV-2 SARS-CoV-2 spike serum South spike Spike protein Strains target Therapeutics Vaccine Vaccines variants of concern Y453F [DOI] 10.1002/rmv.2231 PMC 바로가기 [Article Type] Review
COVID-19 in children: an approach for multisystem inflammatory syndromeReview Published on 2021-10-262022-10-31 Journal: Egyptian Pediatric Association Gazette [Category] COVID-19, [키워드] acute respiratory syndrome Adults approach article cause characterized children clinical evidence clinical feature coronavirus coronavirus disease Coronavirus-2 Corticosteroids COVID-19 COVID-19 patients database diagnosed Diagnosis elevated exaggerated immune response exclusion Fever gastrointestinal involvement Hyperinflammatory Hyperinflammatory syndrome immunoglobulins Infection Inflammatory inflammatory markers information Intravenous immunoglobulin IVIG Kawasaki lack lower mortality management mechanism Mild symptom MIS-C multiorgan failure Multisystem inflammatory syndrome Organ failure pathophysiologic pathophysiology pediatric pediatrics Rash retrieved SARS-CoV-2 SARS-COV-2 infection searched Specific subsequent syndrome Tocilizumab Topic treated Trial [DOI] 10.1186/s43054-021-00082-y PMC 바로가기 [Article Type] Review
Case Report: Cyclophosphamide in COVID-19 – when an absolute contraindication is an absolute necessityCase Report Published on 2021-10-252022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] abnormality Acute kidney injury acute respiratory distress alveolar alveolar haemorrhage Antibiotics antibody antibody panel carried changes in Corticosteroid Course COVID-19 COVID-19 diagnosis Cyclophosphamide cytoplasmic Diagnosis Dyspnoea Fever greater had no immunoglobulins in some initial treatment initiated intravenous kidney Kidney function knowledge Laboratory Laboratory test life-threatening lung other disease p-ANCA parameter Patient Pneumonia positive prevented pulmonary radiological Remdesivir renal retrieved SARS-CoV-2 syndrome the patient treating SARS-CoV-2 infection Treatment Vasculitis [DOI] 10.12688/f1000research.55625.2 PMC 바로가기 [Article Type] Case Report