Pro-inflammatory microenvironment and systemic accumulation of CXCR3+ cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2CXCR3+ 세포의 염증 유발 미세 환경 및 전신 축적은 SARS-CoV-2에 감염된 늙은 붉은털 원숭이의 폐 병리를 악화시킵니다.Article Published on 2021-09-012022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model Apoptosis autophagy both lungs CD8+ cell CD8+ cells Cell cells changes in Chemokine receptor coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 CXCR3 demonstrated elevated exacerbate feature FFPE formalin formalin-fixed paraffin-embedded IFN-α IL-6 immunopathological immunopathology infected with SARS-CoV-2 Infection Infectious diseases interferon interleukin interleukin 6 lung Lung pathology lung tissue Lungs microenvironment motif multiplex immunofluorescence NF-κB nuclear paraffin Peripheral blood pro-inflammatory protein expression Quantitative analysis respiratory rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 significantly staining T cell T-box tissue Treatment understanding [DOI] 10.1038/s41392-021-00734-w PMC 바로가기 [Article Type] Article
Natural Killer Cells as Key Mediators in Type I Diabetes ImmunopathologyReview Published on 2021-08-202023-06-14 Journal: Frontiers in Immunology [Category] MERS, [키워드] Autoimmune beta cell immunopathology Natural killer cells Type 1 diabetes [DOI] 10.3389/fimmu.2021.722979 PMC 바로가기 [Article Type] Review
Expansion of Myeloid Derived Suppressor Cells Contributes to Platelet Activation by L-Arginine Deprivation during SARS-CoV-2 InfectionBrief Report Published on 2021-08-172022-10-31 Journal: Cells [Category] COVID-19, MERS, [키워드] activated Cell complex Concentration correlated COVID-19 COVID-19 pathogenesis Critical driving evaluated Ex vivo expansion expression Frequency healthy control healthy donors highlighting immunopathology in vitro induce L-Arginine massive MDSC myeloid PAC-1 Platelet platelet activation positive correlation reducing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patient suppressor thrombotic event triggering [DOI] 10.3390/cells10082111 PMC 바로가기 [Article Type] Brief Report
HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot StudyArticle Published on 2021-08-162022-10-28 Journal: Biomolecules [Category] COVID-19, MERS, [키워드] Activation addition affected affecting CD4 CD8 COVID-19 deregulation develop expression greater health system heme HMGB1 HO-1 immune immunohistochemistry immunolabeling immunopathology increasingly Lungs manifestation marker morphology New not differ other organ patients positive reduced Result SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 positive patient SARS-CoV-2 positive patients significantly skin statistically subject Support T lymphocyte TIM-3 upper airway [DOI] 10.3390/biom11081219 PMC 바로가기 [Article Type] Article
Coronavirus Pseudotypes for All Circulating Human Coronaviruses for Quantification of Cross-Neutralizing Antibody Responses교차 중화 항체 반응의 정량화를위한 모든 순환 인간 코로나 바이러스에 대한 코로나 바이러스 의사 타입Article Published on 2021-08-102022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] ACE2 antibody antibody cross-reactivity Antibody neutralization best Betacoronavirus breadth can be used Cell cell line cells CHO cell CHO cells Clinical outcome condition coronavirus COVID-19 COVID-19 disease COVID-2019 cross-reactivity disease Disease progression Effect Endemic envelope Haemagglutinin HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs HEK293T HKU1 HUH7 cells Human human coronavirus Immunity immunopathology lentiviral MERS MERS-CoV natural infection neutralization Neutralizing NL63 Novel coronavirus novel coronavirus SARS-CoV-2 OC43 pre-existing immunity produced progression Protein Proteins provide pseudotype pseudotype virus pseudotype viruses Pseudotyped virus Research question response Safe SARS-CoV-1 SARS-CoV-2 seasonal coronavirus serological Seropositivity Seven surface proteins target cell target cells the SARS-CoV-2 titre TMPRSS2 TMPRSS2 expression transduced transfected with understanding vaccination viruses [DOI] 10.3390/v13081579 PMC 바로가기 [Article Type] Article
Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model비강 내 I형 인터페론 치료는 SARS-CoV-2 햄스터 모델에서 임상 징후가 발병하기 전에 투여할 때만 유익합니다.Research Article Published on 2021-08-092022-09-10 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] Administered administration Antiviral caused Clinical course Clinical sign clinical trial clinical trials COVID-19 patients days post-infection Deleterious deleterious effects demonstrated disease Effect effector Efficacy and safety Evidence had no Host IFN-α IFNs immunopathology Impaired Infection information interferon interferons Intervention intranasal lung titers MERS MERS-CoV mice modulate observation onset of symptom onset of symptoms patients Post-infection preclinical study produced provide provided SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe COVID-19 shown Signaling Stage the SARS-CoV-2 the timing Therapeutics Treatment Type Type I IFN type I IFNs type I interferon type I interferons Viral viral infections weight loss [DOI] 10.1371/journal.ppat.1009427 PMC 바로가기 [Article Type] Research Article
Neuroimmunology and Novel Methods of Treatment for Acute Transverse MyelitisNeurology Published on 2021-08-092022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute transverse myelitis addition age ATM Biomarker blocker Cell clinical trial defined described Diagnostic Criteria etiology fampridine highlight immunomodulatory therapy immunopathology Immunosuppressive agents Inflammatory response Injury Myelitis Neuroimmunology neurologic novel outcome pathophysiology plasma exchange therapy Potassium Potential treatment Radiographic Research restricted progenitor cells therapeutic Transverse Treatment [DOI] 10.7759/cureus.17043 PMC 바로가기 [Article Type] Neurology
Autoantibodies stabilize neutrophil extracellular traps in COVID-19자가 항체는 COVID-19에서 호중구 세포외 트랩을 안정화합니다Research Article Published on 2021-08-092022-09-10 Journal: JCI Insight [Category] MERS, SARS, 진단, 치료제, [키워드] Adaptive immunity antibodies antibody associations autoantibodies autoantibody Autoimmunity circulating clearance contribute correlation COVID-19 COVID-19 sera D-dimer Degradation degrade demonstrated determine Efficiency fraction function functional greater healthy control healthy controls Hospitalized IgG IgG and IgM IgM immunopathology impair individual inherent inverse correlation Level mechanical ventilation NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils oxygen oxygen supplementation Oxygenation Patient patients purified required sera serum severe COVID-19 Thromboinflammation variety with COVID-19 [DOI] 10.1172/jci.insight.150111 PMC 바로가기 [Article Type] Research Article
Differential immune responses in pregnant patients recovered from COVID-19Clinical Trial Published on 2021-07-292022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 임상, 진단, [키워드] Activation Adaptive immune response analyzed applied C-reactive protein cells chemotaxis Clinical characteristics contribute COVID-19 COVID-19 patient Evidence female female patient General population healthy donors Hospitalized IL-6 immune response immunopathology indicate Infectious diseases Inflammation Innate immune cells interferon response lymphopenia monocyte mononuclear cell mRNA NKT pathway Peripheral blood Pregnancy pregnant pregnant patient pregnant patients protective immunity risk factor SARS-CoV-2 Sequencing severe COVID-19 single-cell susceptible systemically T cell unique viral infection women [DOI] 10.1038/s41392-021-00703-3 PMC 바로가기 [Article Type] Clinical Trial
Human Coronaviruses: Counteracting the Damage by StormReview Published on 2021-07-272022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ADE Antibody-dependent enhancement Antiviral agents caused cell-mediated immune characteristic coronavirus COVID-19 COVID-19 pandemic CoVs Cytokine storm damage disease dysregulated elicit greater HCoV highlight highly pathogenic Human human coronaviruses IFN immune immune response immunopathology IMPROVE Infection interferon long non-coding RNA MERS-CoV obese Outbreaks over overlapping pandemic peptide progression Rapamycin regulated risk factor SARS-CoV-2 severe disease similarity storm suggested T-cell treatment approach Vaccine vaccine response [DOI] 10.3390/v13081457 PMC 바로가기 [Article Type] Review