Commentary: Coronavirus and Obesity: Could Insulin Resistance Mediate the Severity of Covid-19 Infection?Public Health Published on 2020-07-072022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] COVID-19 insulin resistance metabolic syndrome (MES) non-alchoholic fatty liver disease obesity resistance [DOI] 10.3389/fpubh.2020.00351 PMC 바로가기 [Article Type] Public Health
Metabolic Impacts of Confinement during the COVID-19 Pandemic Due to Modified Diet and Physical Activity HabitsReview Published on 2020-05-262022-10-30 Journal: Nutrients [Category] Coronavirus, MERS, SARS, [키워드] activity acute sedentary lifestyle arising cardiovascular disease Chronic diseases condition consequence Consequences COVID-19 COVID-19 pandemic Deleterious detrimental effect diabetes diet dietary intake energy balance Evidence exacerbate Factor fat habit Health help hypertension identify Impact increase increases in Inflammatory cytokines insulin resistance involved mechanism metabolic metabolic consequence metabolic consequences metabolic disorder metabolic syndrome mitigate physical activity Physical inactivity positive positive energy balance potential risk promoted reduce reduced reducing reduction in risk sarcopenia severe COVID-19 severely ill patient step reduction syndrome total body fat turn while with COVID-19 [DOI] 10.3390/nu12061549 PMC 바로가기 [Article Type] Review
The COVID-19 Pandemic during the Time of the Diabetes Pandemic: Likely Fraternal Twins?Review Published on 2020-05-192022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] accompanied adipose tissue dysfunction adverse outcomes affected circulating cytokines complex COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients Critical cytokine Cytokine storm Deleterious develop developmental diabete diabetes diabetics Evidence explain GEMM family study hyperglycemia hyperinflammatory state hyperinsulinemia immune response Infection Infectious disease Inflammation insulin resistance manifestation mechanism meet morbidity multi-organ failure multifactorial Non-communicable disease pandemic pathogen pathology pathway Patient patients with diabete patients with diabetes prevalent proinflammatory prothrombotic recent risk factor severe COVID-19 subject suggested survival susceptibility symptoms of COVID-19 syndrome time triggering underlie [DOI] 10.3390/pathogens9050389 PMC 바로가기 [Article Type] Review
TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral TherapyTAILoR(인간 면역결핍 바이러스[HIV]의 TelmisArtan 및 InsuLin 내성): 복합 항레트로바이러스 요법을 받는 HIV 양성 환자의 인슐린 내성 감소를 위한 Telmisartan의 적응형 설계, 용량 범위 IIb상 무작위 시험Articles and Commentaries Published on 2020-05-152022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] adaptive Analysis antiretroviral drugs Antiretroviral therapy Antiretrovirals ARMS cardiovascular disease check clinical Combination conducted Controlled trial demonstrated Efficacy evaluated fat had no HIV HIV infection homeostasis Human Human immunodeficiency virus identify IIb immunodeficiency virus improvement Improvements index individual Infection insulin insulin resistance Insulin sensitivity interim analysis Intervention investigated ISRCTN liver longitudinal longitudinal analysis measure metabolic abnormalities Metabolic abnormality metabolic disease morbidity and mortality multicenter no difference no differences no significant effect once daily Open-label participant Patient phase plasma Primary outcome primary outcome measure Randomized receiving recruited reduce reduction in Registration resistance Result risk secondary outcome measures significant effect Stage stage II telmisartan Trial with HIV [DOI] 10.1093/cid/ciz589 PMC 바로가기 [Article Type] Articles and Commentaries
Coronavirus and Obesity: Could Insulin Resistance Mediate the Severity of Covid-19 Infection?Public Health Published on 2020-05-122022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] ACE2 coronavirus COVID 19 insulin resistance obesity resistance [DOI] 10.3389/fpubh.2020.00184 PMC 바로가기 [Article Type] Public Health
Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19Original Investigation Published on 2020-05-112022-10-31 Journal: Cardiovascular Diabetology [Category] COVID-19, MERS, [키워드] 95% CI association Cohort confounder coronavirus disease COVID-19 COVID-19 patients death group Deceased diabetes evaluate Glucose hospital increased risk inflammatory factors insulin resistance marker Mild morbidity Mortality outcome Patient patients died patients with COVID-19 Regression Result Severe case severe cases severity significantly significantly higher statistically significant survivor Triglyceride TyG index were used Wuhan [DOI] 10.1186/s12933-020-01035-2 PMC 바로가기 [Article Type] Original Investigation
The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders11번 염색체에 있는 새로운 유전자간 변이의 파생된 대립유전자는 그린랜더의 낮은 체질량 지수 및 유리한 대사 표현형과 관련이 있습니다Research Article Published on 2020-01-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adipose Adipose tissue affected affecting Alaska allele alteration Analysis Arctic association Author Beta biological processe biological processes BMI body mass body mass index body-mass body-mass index cholesterol chromosome chromosome 11 Cohort cohorts contribute derived allele expand Fat mass Frequency G allele G-allele Genetic genetic architecture genetic loci Genetic predisposition Genetic variant genetic variants genome-wide significant HDL-cholesterol identify independent insulin insulin resistance knowledge lean mass measure mechanism Meta-analysis Native obesity performed phenotype physical activity populations remained replicate Replication required risk significantly Stage stage 2 study population target targets the stage tissue traits Treatment Triglyceride variant visceral Waist circumference weight were assessed [DOI] 10.1371/journal.pgen.1008544 PMC 바로가기 [Article Type] Research Article
Previous hepatitis E virus infection, cirrhosis and insulin resistance in patients with chronic hepatitis CArticle Published on 2019-01-012023-06-12 Journal: The Brazilian journal of infectious diseases : an [Category] E형 간염, Fulltext, [키워드] hepatitis C virus hepatitis E virus insulin resistance Liver cirrhosis [DOI] 10.1016/j.bjid.2019.02.002 PMC 바로가기
Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and InfectionArticle Published on 2018-12-042023-06-24 Journal: Cell Metabolism [Category] 신종인플루엔자, [키워드] Adaptive immunity Anti-viral immunity insulin insulin resistance obesity T cell function T cell metabolism [DOI] 10.1016/j.cmet.2018.08.003
Glycogen Synthase Kinase 3β Enhances Hepatitis C Virus Replication by Supporting miR-122Original Research Published on 2018-11-272023-08-30 Journal: Frontiers in Microbiology [Category] E형 간염, [키워드] GSK3α GSK3β hepatitis E virus Host-targeting antivirals insulin resistance miR-122 [DOI] 10.3389/fmicb.2018.02949 PMC 바로가기 [Article Type] Original Research