Limited Sensitivity of a Rapid SARS-CoV-2 Antigen Detection Assay for Surveillance of Asymptomatic Individuals in Thailand태국에서 무증상 개체의 감시를위한 빠른 SARS-COV-2 항원 검출 분석의 제한된 민감도Articles Published on 2021-12-112022-09-10 Journal: The American Journal of Tropical Medicine and Hygi [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI Accuracy activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen asymptomatic individual caused Chain Reaction community transmission Control coronavirus COVID-19 COVID-19 outbreak Cycle threshold value detection determined by disease disease control evaluated Factor feasibility global pandemic highlight individual Infectious disease Limited Logistic Mass screening National operators Outbreaks performed polymerase chain polymerase chain reaction Prevention and control Public public health Rapid Rapid test respiratory SARS-CoV-2 SARS-CoV-2 antigen second wave sensitivity severe acute respiratory syndrome Coronavirus specificity Surveillance temperature Validity Viral Viral load viral loads [DOI] 10.4269/ajtmh.21-0809 PMC 바로가기 [Article Type] Articles
Antibody affinity maturation and cross-variant activity following SARS-CoV-2 mRNA vaccination: Impact of prior exposure and sexResearch paper Published on 2021-12-102022-11-01 Journal: EBioMedicine [Category] COVID-19, SARS, [키워드] Advancing Affinity maturation Alliance antibody antibody affinity Award binding center contribute convalescent convalescent individual convalescent individuals countermeasure COVID-19 Department described determine dose FDA female females finding funding Human Impact individual Infection Infectious disease initiative knowledge Limited male manuscript maturation mRNA mRNA vaccination mutant mutants naïve neutralization titer neutralizing antibody NIAID NIH no difference number Participants Plasmon prefusion profile Pseudovirus neutralization assay RBD Receptor binding domain resonance SARS-CoV-2 Science sera service Sex sex differences significantly higher SPR supported surface the SARS-CoV-2 university Vaccine vaccine dose variants variants of concern variants of interest Virus neutralization VOCs VOIs was used [DOI] 10.1016/j.ebiom.2021.103748 PMC 바로가기 [Article Type] Research paper
TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infectionTREM-2는 SARS-CoV-2 감염에서 T 세포 반응의 센서이자 활성제입니다.Research Article Published on 2021-12-082022-09-14 Journal: Science Advances [Category] 유전자 메커니즘, 진단, [키워드] activate activated acute respiratory syndrome Antiviral binding Blood Clinical management complex coronavirus coronavirus disease COVID-19 cytokine description domain Drug discovery expressed Immunoglobulin induce Infection interferon-γ intrinsic knockout mice Limited lung M protein membrane membrane protein mouse hepatitis virus murine myeloid cell Necrosis pathway patients with COVID-19 Phosphorylation promoted Protein pseudovirus receptor recognize SARS-CoV-2 SARS-COV-2 infection Stat1 T cell T cell response T helper cell Transcription triggering Vaccine development viral clearance [DOI] 10.1126/sciadv.abi6802 PMC 바로가기 [Article Type] Research Article
Limited and Short-Lasting Virus Neutralizing Titers Induced by Inactivated SARS-CoV-2 Vaccine비활성화된 SARS-CoV-2 백신에 의해 유도된 제한적이고 단기적인 바이러스 중화 역가Research Letter Published on 2021-12-012022-09-10 Journal: Emerging Infectious Diseases [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome CoronaVac coronavirus coronavirus disease COVID 19 Inactivated SARS-CoV-2 vaccine induced Limited Neutralizing antibodies neutralizing antibody original virus strain recipient recipients respiratory respiratory infections SARS-CoV-2 serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Support Thailand These data titer vaccination Vaccine variants variants of concern viruses [DOI] 10.3201/eid2712.211772 PMC 바로가기 [Article Type] Research Letter
Antibody therapy for COVID-19COVID-19에 대한 항체 요법Review Published on 2021-12-012022-09-11 Journal: Current opinion in allergy and clinical immunology [Category] SARS, 임상, 진단, [키워드] antibody Antibody therapy appear best classical Clinical effect Combination coronavirus coronavirus 2 COVID-19 hyperimmune IgG Immunoglobulin immunoglobulin M Immunotherapy Infection initiated Limited monoclonal antibody monoclonal antibody therapy patients with COVID-19 plasma plasma therapy progressed recent Receptor-binding domain respiratory Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein the disease the receptor-binding domain the spike protein therapeutic therapy [DOI] 10.1097/ACI.0000000000000787 PMC 바로가기 [Article Type] Review
Genomic epidemiology and the role of international and regional travel in the SARS-CoV-2 epidemic in Zimbabwe: a retrospective study of routinely collected surveillance data짐바브웨 SARS-CoV-2 전염병에서 게놈 역학과 국제 및 지역 여행의 역할: 일상적으로 수집되는 감시 데이터에 대한 후향적 연구Article Published on 2021-12-012022-09-11 Journal: The Lancet. Global health [Category] SARS, 변종, 유전자 메커니즘, [키워드] advance Analysis Bayesian methods Biological Biotechnology CDC close contact collected community transmission Council cycle threshold diagnostic effective Epidemic Epidemiology Evolution female participants Follow-up genome sequence Genome sequences implementation independent Infection International Intervention Laboratory less likelihood Limited lineages Maximum likelihood Medical Research Council Migration Molecular epidemiology MOST Mutation nasopharyngeal sample Nasopharyngeal samples nine outbreak PCR test PCR-positive performed Phylogenetic relationship positive processed Public health intervention Quality control quarantine reported Retrospective study Sample SARS-CoV-2 SARS-CoV-2 sequencing Science sequence Sequencing Spike protein Spread study period surveillance data symptomatic the SARS-CoV-2 the spike protein Transmission Travel variants virus WHO whole genome whole genome sequence Whole genome sequencing Zimbabwe [DOI] 10.1016/S2214-109X(21)00434-4 PMC 바로가기 [Article Type] Article
Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population라틴계 집단에서 자연 감염 또는 COVID-19 백신에 의해 부여 된 중화의 효과에 대한 델타 변형 돌연변이가 제한된 영향Comparative Study Published on 2021-11-302022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] breadth COVID-19 COVID-19 vaccine Delta delta variant doses Epsilon Evidence Impact impacted individual individuals induce Latino Limited natural neutralization neutralization capacity Neutralizing activity Neutralizing antibodies neutralizing antibody Population protection public health system public health systems SARS-CoV-2 SARS-CoV-2 pandemic serology tested Transmissibility vaccinated individual vaccine dose variant variants virulence [DOI] 10.3390/v13122405 PMC 바로가기 [Article Type] Comparative Study
Direct Viral RNA Detection of SARS-CoV-2 and DENV in Inactivated Samples by Real-Time RT-qPCR: Implications for Diagnosis in Resource Limited Settings with Flavivirus Co-CirculationArticle Published on 2021-11-292022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] biosafety Cell culture clinical sample country COVID-19 pandemic demonstrated DENV DENV-2 detection Diagnostic method diagnostic reagent diagnostic tests Direct direct RT-qPCR early stage feasible flavivirus gold standard heat inactivation heat-inactivated heat-inactivation include limitation Limited Outbreaks overcome protocols provide Rapid reduce resource risk RNA RT-qPCR Sample SARS-CoV-2 SARS-CoV-2 detection setting specimen starting point utility Viral detection viral genome viral infection Viral RNA virus co-circulation virus inactivation [DOI] 10.3390/pathogens10121558 PMC 바로가기 [Article Type] Article
Transcriptional Profiling and Machine Learning Unveil a Concordant Biosignature of Type I Interferon-Inducible Host Response Across Nasal Swab and Pulmonary Tissue for COVID-19 Diagnosis전사 프로파일링 및 기계 학습, COVID-19 진단을 위한 비강 면봉 및 폐 조직 전반에 걸쳐 I형 인터페론 유도성 숙주 반응의 일치하는 생체특징 공개Immunology Published on 2021-11-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] adjusted adopted Analysis approach biosignature BST2 caused complementary computational analysis concordant conserved COVID-19 COVID-19 diagnosis data interpretation dataset Diagnosis Diagnostic method embedding Factor false-negative Genes geometric global pandemic GSE147507 heterogeneous high mortality homological Host host response IFIT1 IFIT2 IFIT3 IFITM1 IFN-I IFN-I signaling infection control Interferome interferon involved ISG15 Limited lung tissue machine learning morbidity MX1 MX2 nasal swab NCBI-GEO network OAS1 OAS2 OAS3 OASL objective other respiratory infections outcome Profiling pulmonary respiratory respiratory infections response Result retrieved RNA-seq data RNA-sequencing RSAD2 RT-PCR SARS-CoV-2 SARS-CoV-2 virus sequencing data severity of COVID-19 similarity Stat1 stochastic stratified transcriptional transcriptional level transcriptomics Type type I interferon virus was used WGCNA [DOI] 10.3389/fimmu.2021.733171 PMC 바로가기 [Article Type] Immunology
The influence of sex, gender, age, and ethnicity on psychosocial factors and substance use throughout phases of the COVID-19 pandemicResearch Article Published on 2021-11-222022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] age alcohol Analysis Anxiety asked Cohort Community COVID-19 COVID-19 pandemic determine Effect evaluate exhibiting Factor FIVE Gender greater groups highlight Impact increase in individual individuals Limited loneliness men mental health objective Other outcome outcomes pandemic Pandemics participant Participants physical Population predictor Prevalence public health measure Rapid recruited reported Research Result SARS-CoV-2 Sex significant effect significantly Stress Substance use Symptom Symptoms symptoms of depression women [DOI] 10.1371/journal.pone.0259676 PMC 바로가기 [Article Type] Research Article